Brent Martin
Brent Martin
Chemical Biology, Scorpion Therapeutics
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New biarsenical ligands and tetracysteine motifs for protein labeling in vitro and in vivo: synthesis and biological applications
SR Adams, RE Campbell, LA Gross, BR Martin, GK Walkup, Y Yao, ...
Journal of the American Chemical Society 124 (21), 6063-6076, 2002
Large-scale profiling of protein palmitoylation in mammalian cells
BR Martin, BF Cravatt
Nature methods 6 (2), 135-138, 2009
Mammalian cell–based optimization of the biarsenical-binding tetracysteine motif for improved fluorescence and affinity
BR Martin, BNG Giepmans, SR Adams, RY Tsien
Nature biotechnology 23 (10), 1308-1314, 2005
Global profiling of dynamic protein palmitoylation
BR Martin, C Wang, A Adibekian, SE Tully, BF Cravatt
Nature methods 9 (1), 84-89, 2012
Click-generated triazole ureas as ultrapotent in vivo–active serine hydrolase inhibitors
A Adibekian, BR Martin, C Wang, KL Hsu, DA Bachovchin, S Niessen, ...
Nature chemical biology 7 (7), 469-478, 2011
Profiling targets of the irreversible palmitoylation inhibitor 2-bromopalmitate
D Davda, MA El Azzouny, CTMB Tom, JL Hernandez, JD Majmudar, ...
ACS chemical biology 8 (9), 1912-1917, 2013
DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells
Y Li, BR Martin, BF Cravatt, SL Hofmann
Journal of Biological Chemistry 287 (1), 523-530, 2012
Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes
A Adibekian, BR Martin, JW Chang, KL Hsu, K Tsuboi, DA Bachovchin, ...
Journal of the American Chemical Society 134 (25), 10345-10348, 2012
Protein depalmitoylases
SJ Won, M Cheung See Kit, BR Martin
Critical reviews in biochemistry and molecular biology 53 (1), 83-98, 2018
Dimethyl itaconate is not metabolized into itaconate intracellularly
M ElAzzouny, CTMB Tom, CR Evans, LL Olson, MJ Tanga, KA Gallagher, ...
Journal of Biological Chemistry 292 (12), 4766-4769, 2017
Global analysis of palmitoylated proteins in Toxoplasma gondii
IT Foe, MA Child, JD Majmudar, S Krishnamurthy, WA van der Linden, ...
Cell host & microbe 18 (4), 501-511, 2015
Variable-velocity traveling-wave ion mobility separation enhancing peak capacity for data-independent acquisition proteomics
SE Haynes, DA Polasky, SM Dixit, JD Majmudar, K Neeson, BT Ruotolo, ...
Analytical chemistry 89 (11), 5669-5672, 2017
Tunable heteroaromatic sulfones enhance in-cell cysteine profiling
HF Motiwala, YH Kuo, BL Stinger, BA Palfey, BR Martin
Journal of the American Chemical Society 142 (4), 1801-1810, 2019
APT2 inhibition restores scribble localization and S-palmitoylation in snail-transformed cells
JL Hernandez, D Davda, MCS Kit, JD Majmudar, SJ Won, M Gang, ...
Cell chemical biology 24 (1), 87-97, 2017
Isoform-specific PKA dynamics revealed by dye-triggered aggregation and DAKAP1α-mediated localization in living cells
BR Martin, TJ Deerinck, MH Ellisman, SS Taylor, RY Tsien
Chemistry & biology 14 (9), 1031-1042, 2007
Molecular mechanism for isoform-selective inhibition of acyl protein thioesterases 1 and 2 (APT1 and APT2)
SJ Won, D Davda, KJ Labby, SY Hwang, R Pricer, JD Majmudar, ...
ACS chemical biology 11 (12), 3374-3382, 2016
Proteomic analysis of S-acylated proteins in human B cells reveals palmitoylation of the immune regulators CD20 and CD23
C Ivaldi, BR Martin, S Kieffer-Jaquinod, A Chapel, T Levade, J Garin, ...
PloS one 7 (5), e37187, 2012
A Mechanism Regulating G Protein-coupled Receptor Signaling That Requires Cycles of Protein Palmitoylation and Depalmitoylation*♦
L Jia, M Chisari, MH Maktabi, C Sobieski, H Zhou, AM Konopko, ...
Journal of Biological Chemistry 289 (9), 6249-6257, 2014
Fat chance! Getting a grip on a slippery modification
CTMB Tom, BR Martin
ACS chemical biology 8 (1), 46-57, 2013
Harnessing redox cross-reactivity to profile distinct cysteine modifications
JD Majmudar, AM Konopko, KJ Labby, CTMB Tom, JE Crellin, A Prakash, ...
Journal of the American Chemical Society 138 (6), 1852-1859, 2016
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