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| De novo NAD+ synthesis enhances mitochondrial function and improves health E Katsyuba, A Mottis, M Zietak, F De Franco, V van der Velpen, K Gariani, ... Nature 563 (7731), 354-359, 2018 | 356 | 2018 |
| Functional characterization of the semisynthetic bile acid derivative INT-767, a dual farnesoid X receptor and TGR5 agonist G Rizzo, D Passeri, F De Franco, G Ciaccioli, L Donadio, G Rizzo, ... Molecular pharmacology 78 (4), 617-630, 2010 | 209 | 2010 |
| Semisynthetic bile acid FXR and TGR5 agonists: physicochemical properties, pharmacokinetics, and metabolism in the rat A Roda, R Pellicciari, A Gioiello, F Neri, C Camborata, D Passeri, ... Journal of Pharmacology and Experimental Therapeutics 350 (1), 56-68, 2014 | 66 | 2014 |
| Discovery of 3α, 7α, 11β-trihydroxy-6α-ethyl-5β-cholan-24-oic acid (TC-100), a novel bile acid as potent and highly selective FXR agonist for enterohepatic disorders R Pellicciari, D Passeri, F De Franco, S Mostarda, P Filipponi, C Colliva, ... Journal of medicinal chemistry 59 (19), 9201-9214, 2016 | 56 | 2016 |
| Pyrazole [3, 4-e][1, 4] thiazepin-7-one derivatives as a novel class of Farnesoid X Receptor (FXR) agonists M Marinozzi, A Carotti, E Sansone, A Macchiarulo, E Rosatelli, R Sardella, ... Bioorganic & medicinal chemistry 20 (11), 3429-3445, 2012 | 55 | 2012 |
| Probing the binding site of bile acids in TGR5 A Macchiarulo, A Gioiello, C Thomas, TWH Pols, R Nuti, C Ferrari, ... ACS medicinal chemistry letters 4 (12), 1158-1162, 2013 | 54 | 2013 |
| α-Amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) inhibitors as novel modulators of de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis R Pellicciari, P Liscio, N Giacchè, F De Franco, A Carotti, J Robertson, ... Journal of medicinal chemistry 61 (3), 745-759, 2018 | 41 | 2018 |
| Rad51/BRCA2 disruptors inhibit homologous recombination and synergize with olaparib in pancreatic cancer cells M Roberti, F Schipani, G Bagnolini, D Milano, E Giacomini, F Falchi, ... European Journal of Medicinal Chemistry 165, 80-92, 2019 | 38 | 2019 |
| Garcinoic acid is a natural and selective agonist of pregnane X receptor D Bartolini, F De Franco, P Torquato, R Marinelli, B Cerra, R Ronchetti, ... Journal of Medicinal Chemistry 63 (7), 3701-3712, 2020 | 36 | 2020 |
| Synthetic lethality in pancreatic cancer: Discovery of a new RAD51-BRCA2 small molecule disruptor that inhibits homologous recombination and synergizes with olaparib G Bagnolini, D Milano, M Manerba, F Schipani, JA Ortega, D Gioia, ... Journal of Medicinal Chemistry 63 (5), 2588-2619, 2020 | 33 | 2020 |
| Synthesis and structure-activity relationships of amino acid conjugates of cholanic acid as antagonists of the EphA2 receptor S Russo, M Incerti, M Tognolini, R Castelli, D Pala, I Hassan-Mohamed, ... Molecules 18 (10), 13043-13060, 2013 | 18 | 2013 |
| Synthesis of atypical bile acids for use as investigative tools for the genetic defect of 3β-hydroxy-Δ5-C27-steroid oxidoreductase deficiency A Gioiello, B Cerra, W Zhang, GP Vallerini, G Costantino, F De Franco, ... The Journal of Steroid Biochemistry and Molecular Biology 144, 348-360, 2014 | 14 | 2014 |
| A non-redundant function of cyclin E1 in hematopoietic stem cells S Campaner, A Viale, S De Fazio, M Doni, F De Franco, L D'artista, ... Cell Cycle 12 (23), 3663-3672, 2013 | 14 | 2013 |
| Identification of RAD51–BRCA2 Inhibitors Using N-Acylhydrazone-Based Dynamic Combinatorial Chemistry G Bagnolini, B Balboni, F Schipani, D Gioia, M Veronesi, F De Franco, ... ACS Medicinal Chemistry Letters 13 (8), 1262-1269, 2022 | 7 | 2022 |
| Innovations and Emerging Therapies to Combat Renal Cell Damage: NAD+ As a Drug Target CL Manrique-Caballero, JA Kellum, H Gómez, F De Franco, N Giacche, ... Antioxidants & Redox Signaling 35 (17), 1449-1466, 2021 | 7 | 2021 |
| Structural basis of human dimeric α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase inhibition with TES-1025 M Cianci, N Giacchè, L Cialabrini, A Carotti, P Liscio, E Rosatelli, ... Frontiers in Molecular Biosciences 9, 834700, 2022 | 3 | 2022 |
| Development of 3α, 7α-dihydroxy-6α-ethyl-24-nor-5β-cholan-23-sulfate sodium salt (INT-767): Process optimization, synthesis and characterization of metabolites B Cerra, F Venturoni, M Souma, G Ceccarelli, AM Lozza, D Passeri, ... European Journal of Medicinal Chemistry 242, 114652, 2022 | 2 | 2022 |
| An 19F NMR fragment-based approach for the discovery and development of BRCA2-RAD51 inhibitors to pursuit synthetic lethality in combination with PARP inhibition in pancreatic … SH Myers, L Poppi, F Rinaldi, M Veronesi, A Ciamarone, V Previtali, ... European Journal of Medicinal Chemistry 265, 116114, 2024 | 1 | 2024 |
| Chemical exploration of TGR5 functional hot-spots: Synthesis and structure-activity relationships of C7-and C23-Substituted cholic acid derivatives E Rosatelli, A Carotti, B Cerra, F De Franco, D Passeri, R Pellicciari, ... European Journal of Medicinal Chemistry 261, 115851, 2023 | 1 | 2023 |
