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Kyung Yong Lee
Kyung Yong Lee
Research Scientist, University of Virginia
Verificeret mail på virginia.edu
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Human umbilical cord blood–derived mesenchymal stem cells undergo cellular senescence in response to oxidative stress
E Ko, KY Lee, DS Hwang
Stem cells and development 21 (11), 1877-1886, 2012
1352012
The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination
J Park, DT Long, KY Lee, T Abbas, E Shibata, M Negishi, Y Luo, ...
Molecular and cellular biology 33 (8), 1632-1644, 2013
1252013
A new lncRNA, APTR, associates with and represses the CDKN1A/p21 promoter by recruiting polycomb proteins
M Negishi, SP Wongpalee, S Sarkar, J Park, KY Lee, Y Shibata, BJ Reon, ...
PLoS One 9 (4), e95216, 2014
942014
MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex
KY Lee, JS Im, E Shibata, J Park, N Handa, SC Kowalczykowski, A Dutta
Nature communications 6 (1), 7744, 2015
872015
TopBP1 deficiency causes an early embryonic lethality and induces cellular senescence in primary cells
Y Jeon, E Ko, KY Lee, MJ Ko, SY Park, J Kang, CH Jeon, H Lee, ...
Journal of biological chemistry 286 (7), 5414-5422, 2011
752011
Targeted CRISPR screening identifies PRMT5 as synthetic lethality combinatorial target with gemcitabine in pancreatic cancer cells
X Wei, J Yang, SJ Adair, H Ozturk, C Kuscu, KY Lee, WJ Kane, PE O’Hara, ...
Proceedings of the National Academy of Sciences 117 (45), 28068-28079, 2020
622020
Phosphorylation of ORC2 protein dissociates origin recognition complex from chromatin and replication origins
KY Lee, SW Bang, SW Yoon, SH Lee, JB Yoon, DS Hwang
Journal of Biological Chemistry 287 (15), 11891-11898, 2012
592012
The deubiquitinase USP46 is essential for proliferation and tumor growth of HPV-transformed cancers
S Kiran, A Dar, SK Singh, KY Lee, A Dutta
Molecular cell 72 (5), 823-835. e5, 2018
502018
Human TopBP1 participates in cyclin E/CDK2 activation and preinitiation complex assembly during G1/S transition
Y Jeon, KY Lee, MJ Ko, YS Lee, S Kang, DS Hwang
Journal of biological chemistry 282 (20), 14882-14890, 2007
482007
ASF1a promotes non-homologous end joining repair by facilitating phosphorylation of MDC1 by ATM at double-strand breaks
KY Lee, JS Im, E Shibata, A Dutta
Molecular cell 68 (1), 61-75. e5, 2017
392017
ATR checkpoint kinase and CRL1βTRCP collaborate to degrade ASF1a and thus repress genes overlapping with clusters of stalled replication forks
JS Im, M Keaton, KY Lee, P Kumar, J Park, A Dutta
Genes & development 28 (8), 875-887, 2014
352014
The pan-cancer landscape of prognostic germline variants in 10,582 patients
A Chatrath, R Przanowska, S Kiran, Z Su, S Saha, B Wilson, ...
Genome medicine 12, 1-18, 2020
262020
Dimeric configuration of SeqA protein bound to a pair of hemi-methylated GATC sequences
S Kang, JS Han, KP Kim, HY Yang, KY Lee, CB Hong, DS Hwang
Nucleic acids research 33 (5), 1524-1531, 2005
262005
Chk1 promotes non-homologous end joining in G1 through direct phosphorylation of ASF1A
KY Lee, A Dutta
Cell reports 34 (4), 2021
102021
Dephosphorylation of Orc2 by protein phosphatase 1 promotes the binding of the origin recognition complex to chromatin
KY Lee, JS Bae, S Yoon, DS Hwang
Biochemical and Biophysical Research Communications 448 (4), 385-389, 2014
102014
Human Primpol1: a novel guardian of stalled replication forks
JS Im, KY Lee, LW Dillon, A Dutta
EMBO reports 14 (12), 1032-1033, 2013
82013
Protein phosphatase 1 dephosphorylates Orc2
KY Lee, JS Bae, GS Kim, DS Hwang
Biochemical and Biophysical Research Communications 447 (3), 437-440, 2014
42014
Initiation of replication in Xenopus egg extracts at a spatially defined origin
KY Lee, A Dutta
Cell Cycle 14 (15), 2391-2391, 2015
2015
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Artikler 1–18