| Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy C Fugier, AF Klein, C Hammer, S Vassilopoulos, Y Ivarsson, A Toussaint, ... Nature medicine 17 (6), 720-725, 2011 | 347 | 2011 |
| Large CTG repeats trigger p16-dependent premature senescence in myotonic dystrophy type 1 muscle precursor cells A Bigot, AF Klein, E Gasnier, V Jacquemin, P Ravassard, G Butler-Browne, ... The American journal of pathology 174 (4), 1435-1442, 2009 | 105 | 2009 |
| Satellite cell dysfunction contributes to the progressive muscle atrophy in myotonic dystrophy type 1 LE Thornell, M Lindstöm, V Renault, A Klein, V Mouly, T Ansved, ... Neuropathology and applied neurobiology 35 (6), 603-613, 2009 | 104 | 2009 |
| New function for the RNA helicase p68/DDX5 as a modifier of MBNL1 activity on expanded CUG repeats FX Laurent, A Sureau, AF Klein, F Trouslard, E Gasnier, D Furling, J Marie Nucleic acids research 40 (7), 3159-3171, 2012 | 96 | 2012 |
| Selective silencing of mutated mRNAs in DM1 by using modified hU7-snRNAs V François, AF Klein, C Beley, A Jollet, C Lemercier, L Garcia, D Furling Nature structural & molecular biology 18 (1), 85-87, 2011 | 91 | 2011 |
| Efficient CRISPR/Cas9-mediated editing of trinucleotide repeat expansion in myotonic dystrophy patient-derived iPS and myogenic cells S Dastidar, S Ardui, K Singh, D Majumdar, N Nair, Y Fu, D Reyon, ... Nucleic acids research 46 (16), 8275-8298, 2018 | 89 | 2018 |
| Immortalized human myotonic dystrophy muscle cell lines to assess therapeutic compounds L Arandel, M Polay Espinoza, M Matloka, A Bazinet, D de Dea Diniz, ... Disease models & mechanisms 10 (4), 487-497, 2017 | 87 | 2017 |
| PABPN1 overexpression leads to upregulation of genes encoding nuclear proteins that are sequestered in oculopharyngeal muscular dystrophy nuclear inclusions LP Corbeil-Girard, AF Klein, AMJ Sasseville, H Lavoie, MJ Dicaire, ... Neurobiology of disease 18 (3), 551-567, 2005 | 86 | 2005 |
| Peptide-conjugated oligonucleotides evoke long-lasting myotonic dystrophy correction in patient-derived cells and mice AF Klein, MA Varela, L Arandel, A Holland, N Naouar, A Arzumanov, ... The Journal of clinical investigation 129 (11), 4739-4744, 2019 | 75 | 2019 |
| Gain of RNA function in pathological cases: Focus on myotonic dystrophy AF Klein, E Gasnier, D Furling Biochimie 93 (11), 2006-2012, 2011 | 59 | 2011 |
| Genome editing of expanded CTG repeats within the human DMPK gene reduces nuclear RNA foci in the muscle of DM1 mice ML Scrudato, K Poulard, C Sourd, S Tomé, AF Klein, G Corre, A Huguet, ... Molecular Therapy 27 (8), 1372-1388, 2019 | 52 | 2019 |
| PABPN1 polyalanine tract deletion and long expansions modify its aggregation pattern and expression AF Klein, M Ebihara, C Alexander, MJ Dicaire, AMJ Sasseville, ... Experimental cell research 314 (8), 1652-1666, 2008 | 48 | 2008 |
| Therapeutic approaches for dominant muscle diseases: highlight on myotonic dystrophy A F Klein, S Dastidar, D Furling, M K Chuah Current gene therapy 15 (4), 329-337, 2015 | 39 | 2015 |
| Improvement of dystrophic muscle fragility by short-term voluntary exercise through activation of calcineurin pathway in mdx mice C Delacroix, J Hyzewicz, M Lemaitre, B Friguet, Z Li, A Klein, D Furling, ... The American Journal of Pathology 188 (11), 2662-2673, 2018 | 21 | 2018 |
| Two novel COLVI long chains in zebrafish that are essential for muscle development L Ramanoudjame, C Rocancourt, J Lainé, A Klein, L Joassard, C Gartioux, ... Human Molecular Genetics 24 (23), 6624-6639, 2015 | 21 | 2015 |
| The dynamism of PABPN1 nuclear inclusions during the cell cycle AMJ Sasseville, AW Caron, L Bourget, AF Klein, MJ Dicaire, GA Rouleau, ... Neurobiology of disease 23 (3), 621-629, 2006 | 20 | 2006 |
| Reversal of RNA toxicity in myotonic dystrophy via a decoy RNA-binding protein with high affinity for expanded CUG repeats L Arandel, M Matloka, AF Klein, F Rau, A Sureau, M Ney, A Cordier, ... Nature Biomedical Engineering 6 (2), 207-220, 2022 | 19 | 2022 |
| Desmin prevents muscle wasting, exaggerated weakness and fragility, and fatigue in dystrophic mdx mouse A Ferry, J Messéant, A Parlakian, M Lemaitre, P Roy, C Delacroix, ... The Journal of Physiology 598 (17), 3667-3689, 2020 | 17 | 2020 |
| Cells of Matter—In Vitro Models for Myotonic Dystrophy M Matloka, AF Klein, F Rau, D Furling Frontiers in Neurology 9, 361, 2018 | 15 | 2018 |
| Comprehensive transcriptome-wide analysis of spliceopathy correction of myotonic dystrophy using CRISPR-Cas9 in iPSCs-derived cardiomyocytes S Dastidar, D Majumdar, J Tipanee, K Singh, AF Klein, D Furling, ... Molecular Therapy 30 (1), 75-91, 2022 | 13 | 2022 |
