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Zhang Yang
Zhang Yang
Novo Nordisk A/S Cell Therapy R&D unit
Verificeret mail på novonordisk.com
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SARS-CoV-2 infection depends on cellular heparan sulfate and ACE2
TM Clausen, DR Sandoval, CB Spliid, J Pihl, HR Perrett, CD Painter, ...
Cell 183 (4), 1043-1057. e15, 2020
10642020
Engineered CHO cells for production of diverse, homogeneous glycoproteins
Zhang Yang, Shengjun Wang, Adnan Halim, Morten Alder Schulz, Morten Frodin ...
Nature Biotechnology 33 (2015), 842–844, 2015
2622015
An atlas of human glycosylation pathways enables display of the human glycome by gene engineered cells
Y Narimatsu, HJ Joshi, R Nason, J Van Coillie, R Karlsson, L Sun, Z Ye, ...
Molecular cell 75 (2), 394-407. e5, 2019
2122019
Fast and sensitive detection of indels induced by precise gene targeting
Z Yang, C Steentoft, C Hauge, L Hansen, AL Thomsen, F Niola, ...
Nucleic acids research 43 (9), e59-e59, 2015
1772015
The GAGOme: a cell-based library of displayed glycosaminoglycans
YH Chen, Y Narimatsu, TM Clausen, C Gomes, R Karlsson, C Steentoft, ...
Nature methods 15 (11), 881-888, 2018
1252018
Genome editing using FACS enrichment of nuclease-expressing cells and indel detection by amplicon analysis
LA Lonowski, Y Narimatsu, A Riaz, CE Delay, Z Yang, F Niola, K Duda, ...
Nature protocols 12 (3), 581-603, 2017
1152017
Probing the binding specificities of human Siglecs by cell-based glycan arrays
C Büll, R Nason, L Sun, J Van Coillie, D Madriz Sørensen, SJ Moons, ...
Proceedings of the National Academy of Sciences 118 (17), e2026102118, 2021
1022021
High-efficiency genome editing via 2A-coupled co-expression of fluorescent proteins and zinc finger nucleases or CRISPR/Cas9 nickase pairs
K Duda, LA Lonowski, M Kofoed-Nielsen, A Ibarra, CM Delay, Q Kang, ...
Nucleic acids research 42 (10), e84-e84, 2014
1002014
Unfractionated heparin inhibits live wild type SARS‐CoV‐2 cell infectivity at therapeutically relevant concentrations
JA Tree, JE Turnbull, KR Buttigieg, MJ Elmore, N Coombes, J Hogwood, ...
British Journal of Pharmacology 178 (3), 626-635, 2021
992021
The GalNAc-type O-glycoproteome of CHO cells characterized by the SimpleCell strategy
Z Yang, A Halim, Y Narimatsu, HJ Joshi, C Steentoft, KTBG Schjoldager, ...
Molecular & Cellular Proteomics 13 (12), 3224-3235, 2014
892014
A combined zinc/cadmium sensor and zinc/cadmium export regulator in a heavy metal pump
L Bækgaard, MD Mikkelsen, DM Sørensen, JN Hegelund, DP Persson, ...
Journal of Biological Chemistry 285 (41), 31243-31252, 2010
882010
Synthetic heparan sulfate mimetic pixatimod (PG545) potently inhibits SARS-CoV-2 by disrupting the spike–ACE2 interaction
SE Guimond, CJ Mycroft-West, NS Gandhi, JA Tree, TT Le, CM Spalluto, ...
ACS central science 8 (5), 527-545, 2022
802022
A validated gRNA library for CRISPR/Cas9 targeting of the human glycosyltransferase genome
Y Narimatsu, HJ Joshi, Z Yang, C Gomes, YH Chen, FC Lorenzetti, ...
Glycobiology 28 (5), 295-305, 2018
802018
Direct quality control of glycoengineered erythropoietin variants
T Čaval, W Tian, Z Yang, H Clausen, AJR Heck
Nature communications 9 (1), 3342, 2018
772018
Galectin binding to cells and glycoproteins with genetically modified glycosylation reveals galectin–glycan specificities in a natural context
MI Nielsen, J Stegmayr, OC Grant, Z Yang, UJ Nilsson, I Boos, ...
Journal of Biological Chemistry 293 (52), 20249-20262, 2018
742018
INDEL detection, the ‘Achilles heel’of precise genome editing: a survey of methods for accurate profiling of gene editing induced indels
EP Bennett, BL Petersen, IE Johansen, Y Niu, Z Yang, CA Chamberlain, ...
Nucleic Acids Research 48 (21), 11958-11981, 2020
732020
Engineering mammalian mucin-type O-glycosylation in plants
Z Yang, DP Drew, B Jørgensen, U Mandel, SS Bach, P Ulvskov, ...
Journal of Biological Chemistry 287 (15), 11911-11923, 2012
732012
Genetic glycoengineering in mammalian cells
Y Narimatsu, C Büll, YH Chen, HH Wandall, Z Yang, H Clausen
Journal of Biological Chemistry 296, 2021
692021
Characterization of Binding Epitopes of CA125 Monoclonal Antibodies
L Marcos-Silva, Y Narimatsu, A Halim, D Campos, Z Yang, MA Tarp, ...
Journal of proteome research 13 (7), 3349-3359, 2014
642014
The glycosylation design space for recombinant lysosomal replacement enzymes produced in CHO cells
W Tian, Z Ye, S Wang, MA Schulz, J Van Coillie, L Sun, YH Chen, ...
Nature communications 10 (1), 1785, 2019
612019
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