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John Lapek
John Lapek
Principal Scientist
Verified email at belharratx.com
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Cited by
Year
Dysregulated microbial fermentation of soluble fiber induces cholestatic liver cancer
V Singh, B San Yeoh, B Chassaing, X Xiao, P Saha, RA Olvera, JD Lapek, ...
Cell 175 (3), 679-694. e22, 2018
4042018
Essential metabolism for a minimal cell
M Breuer, TM Earnest, C Merryman, KS Wise, L Sun, MR Lynott, ...
Elife 8, e36842, 2019
1452019
Detection of dysregulated protein-association networks by high-throughput proteomics predicts cancer vulnerabilities
JD Lapek Jr, P Greninger, R Morris, A Amzallag, I Pruteanu-Malinici, ...
Nature biotechnology 35 (10), 983-989, 2017
1392017
Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation
BN Nicolay, PS Danielian, F Kottakis, JD Lapek, I Sanidas, WO Miles, ...
Genes & development 29 (17), 1875-1889, 2015
902015
Functional analysis of NsrR, a nitric oxide‐sensing Rrf2 repressor in Neisseria gonorrhoeae
VM Isabella, JD Lapek Jr, EM Kennedy, VL Clark
Molecular microbiology 71 (1), 227-239, 2009
892009
Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor
K Freeman-Cook, RL Hoffman, N Miller, J Almaden, J Chionis, Q Zhang, ...
Cancer cell 39 (10), 1404-1421. e11, 2021
842021
Staphylococcus aureus Membrane-Derived Vesicles Promote Bacterial Virulence and Confer Protective Immunity in Murine Infection Models
F Askarian, JD Lapek Jr, M Dongre, CM Tsai, M Kumaraswamy, A Kousha, ...
Frontiers in microbiology 9, 262, 2018
702018
Mitogen-and stress-activated kinase 1 (MSK1) regulates cigarette smoke-induced histone modifications on NF-κB-dependent genes
IK Sundar, S Chung, J Hwang, JD Lapek Jr, M Bulger, AE Friedman, ...
PloS one 7 (2), e31378, 2012
662012
Quantitative temporal viromics of an inducible HIV-1 model yields insight to global host targets and phospho-dynamics associated with protein Vpr
JD Lapek, MK Lewinski, JM Wozniak, J Guatelli, DJ Gonzalez
Molecular & Cellular Proteomics 16 (8), 1447-1461, 2017
632017
Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer
KD Freeman-Cook, RL Hoffman, DC Behenna, B Boras, J Carelli, W Diehl, ...
Journal of Medicinal Chemistry 64 (13), 9056-9077, 2021
592021
Group B Streptococcus Biofilm Regulatory Protein A Contributes to Bacterial Physiology and Innate Immune Resistance
KA Patras, J Derieux, MM Al-Bassam, N Adiletta, A Vrbanac, JD Lapek, ...
The Journal of infectious diseases 218 (10), 1641-1652, 2018
502018
Proteomic and functional analyses of protein–DNA complexes during gene transfer
MA Badding, JD Lapek, AE Friedman, DA Dean
Molecular Therapy 21 (4), 775-785, 2013
472013
Mitochondrial H+-ATP synthase in human skeletal muscle: contribution to dyslipidaemia and insulin resistance
L Formentini, AJ Ryan, M Gálvez-Santisteban, L Carter, P Taub, JD Lapek, ...
Diabetologia 60, 2052-2065, 2017
462017
Reversible lysine-targeted probes reveal residence time-based kinase selectivity
T Yang, A Cuesta, X Wan, GB Craven, B Hirakawa, P Khamphavong, ...
Nature chemical biology 18 (9), 934-941, 2022
402022
A tyrosine switch on NEDD4-2 E3 ligase transmits GPCR inflammatory signaling
NJ Grimsey, R Narala, CC Rada, S Mehta, BS Stephens, I Kufareva, ...
Cell reports 24 (12), 3312-3323. e5, 2018
402018
Discovery of novel plasma biomarkers for future incident venous thromboembolism by untargeted synchronous precursor selection mass spectrometry proteomics
SB Jensen, K Hindberg, T Solomon, EN Smith, JD Lapek Jr, DJ Gonzalez, ...
Journal of Thrombosis and Haemostasis 16 (9), 1763-1774, 2018
402018
Cardiolipin biosynthesis in Streptococcus mutans is regulated in response to external pH
ME MacGilvray, JD Lapek Jr, AE Friedman, RG Quivey Jr
Microbiology 158 (8), 2133-2143, 2012
362012
Mass spectrometry detection of histidine phosphorylation on NM23-H1
JD Lapek Jr, G Tombline, AE Friedman
Journal of proteome research 10 (2), 751-755, 2011
332011
Phosphoproteomic analysis of protease-activated receptor-1 biased signaling reveals unique modulators of endothelial barrier function
Y Lin, JM Wozniak, NJ Grimsey, S Girada, A Patwardhan, O Molinar-Inglis, ...
Proceedings of the National Academy of Sciences 117 (9), 5039-5048, 2020
312020
Quantitative multiplex substrate profiling of peptidases by mass spectrometry
JD Lapek, Z Jiang, JM Wozniak, E Arutyunova, SC Wang, MJ Lemieux, ...
Molecular & Cellular Proteomics 18 (5), 968a, 2019
312019
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