| IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge SA Khader, GK Bell, JE Pearl, JJ Fountain, J Rangel-Moreno, GE Cilley, ... Nature immunology 8 (4), 369-377, 2007 | 1729 | 2007 |
| Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis HR Conti, F Shen, N Nayyar, E Stocum, JN Sun, MJ Lindemann, AW Ho, ... Journal of Experimental Medicine 206 (2), 299-311, 2009 | 1161 | 2009 |
| Structure–function relationships in the IL-17 receptor: implications for signal transduction and therapy F Shen, SL Gaffen Cytokine 41 (2), 92-104, 2008 | 374 | 2008 |
| Identification of common transcriptional regulatory elements in interleukin-17 target genes F Shen, Z Hu, J Goswami, SL Gaffen Journal of Biological Chemistry 281 (34), 24138-24148, 2006 | 361 | 2006 |
| Cytokines link osteoblasts and inflammation: microarray analysis of interleukin-17-and TNF-α-induced genes in bone cells F Shen, MJ Ruddy, P Plamondon, SL Gaffen Journal of leukocyte biology 77 (3), 388-399, 2005 | 358 | 2005 |
| Interleukin-17 regulates expression of the CXC chemokine LIX/CXCL5 in osteoblasts: implications for inflammation and neutrophil recruitment MJ Ruddy, F Shen, JB Smith, A Sharma, SL Gaffen Journal of leukocyte biology 76 (1), 135-144, 2004 | 259 | 2004 |
| Distinct functional motifs within the IL-17 receptor regulate signal transduction and target gene expression A Maitra, F Shen, W Hanel, K Mossman, J Tocker, D Swart, SL Gaffen Proceedings of the National Academy of Sciences 104 (18), 7506-7511, 2007 | 220 | 2007 |
| The IL‐17 cytokine family SL Gaffen, JM Kramer, JY Jeffrey, F Shen Vitamins & hormones 74, 255-282, 2006 | 215 | 2006 |
| The IL‐17 pathway as a major therapeutic target in autoimmune diseases Y Hu, F Shen, NK Crellin, W Ouyang Annals of the New York Academy of Sciences 1217 (1), 60-76, 2011 | 182 | 2011 |
| IL-17 receptor signaling inhibits C/EBPβ by sequential phosphorylation of the regulatory 2 domain F Shen, N Li, P Gade, DV Kalvakolanu, T Weibley, B Doble, JR Woodgett, ... Science signaling 2 (59), ra8-ra8, 2009 | 162 | 2009 |
| IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail AW Ho, F Shen, HR Conti, N Patel, EE Childs, AC Peterson, ... The Journal of Immunology 185 (2), 1063-1070, 2010 | 144 | 2010 |
| Cutting edge: evidence for ligand-independent multimerization of the IL-17 receptor JM Kramer, L Yi, F Shen, A Maitra, X Jiao, T Jin, SL Gaffen The Journal of Immunology 176 (2), 711-715, 2006 | 141 | 2006 |
| Differential role for c-Rel and C/EBPβ/δ in TLR-mediated induction of proinflammatory cytokines YC Lu, I Kim, E Lye, F Shen, N Suzuki, S Suzuki, S Gerondakis, S Akira, ... The Journal of Immunology 182 (11), 7212-7221, 2009 | 138 | 2009 |
| Cutting edge: identification of a pre-ligand assembly domain (PLAD) and ligand binding site in the IL-17 receptor JM Kramer, W Hanel, F Shen, N Isik, JP Malone, A Maitra, W Sigurdson, ... The Journal of Immunology 179 (10), 6379-6383, 2007 | 70 | 2007 |
| Combined Blockade of TNF-α and IL-17A Alleviates Progression of Collagen-Induced Arthritis without Causing Serious Infections in Mice GSLOT Shen F, Verma AH, Volk A, Jones B, Coleman BM, Loza MJ, Malaviya R ... J Immunol 202 (7), 2017, 2019 | 35 | 2019 |
| Discovery and optimization of a series of small-molecule allosteric inhibitors of MALT1 protease T Lu, PJ Connolly, U Philippar, W Sun, MD Cummings, K Barbay, L Gys, ... Bioorganic & Medicinal Chemistry Letters 29 (23), 126743, 2019 | 13 | 2019 |
| Characterization of concurrent target suppression by JNJ-61178104, a bispecific antibody against human tumor necrosis factor and interleukin-17A S Zheng, F Shen, B Jones, D Fink, B Geist, I Nnane, Z Zhou, J Hall, ... MAbs 12 (1), 1770018, 2020 | 8 | 2020 |
| Pharmacokinetics, Pharmacodynamics, Immunogenicity, Safety, and Tolerability of JNJ-61178104, a Novel Tumor Necrosis Factor-Alpha and Interleukin-17A Bispecific Antibody, in … XZ Akpalu DE, Frederick B, Nnane IP, Yao Z, Shen F, Ort T, Fink D, Dogmanits ... J Clin Pharmacol, 2019 | 7 | 2019 |
| Bispecific Anti-TNF-Alpha/IL17A Antibodies and Anti-TNF-Alpha Antibodies and Methods of Their Use M Chiu, J Nemeth-Seay, T Ort, F Shen US Patent App. 15/417,560, 2017 | 5 | 2017 |
| Pre-ligand assembly domain of the IL-17 receptor SL Gaffen, F Shen, W Hanel, J Kramer, JP Malone, M Wittekind, R Paxton US Patent 8,460,647, 2013 | 4 | 2013 |
Heather ContiAssociate Professor, University of ToledoVerificeret mail på utoledo.edu
