| TGR5-mediated bile acid sensing controls glucose homeostasis C Thomas, A Gioiello, L Noriega, A Strehle, J Oury, G Rizzo, ... Cell metabolism 10 (3), 167-177, 2009 | 1866 | 2009 |
| TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading TWH Pols, M Nomura, T Harach, G Lo Sasso, MH Oosterveer, C Thomas, ... Cell metabolism 14 (6), 747-757, 2011 | 553 | 2011 |
| Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure− activity relationships, and molecular modeling studies H Sato, A Macchiarulo, C Thomas, A Gioiello, M Une, AF Hofmann, ... Journal of medicinal chemistry 51 (6), 1831-1841, 2008 | 336 | 2008 |
| Discovery of 6α-ethyl-23 (S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity R Pellicciari, A Gioiello, A Macchiarulo, C Thomas, E Rosatelli, B Natalini, ... Journal of medicinal chemistry 52 (24), 7958-7961, 2009 | 265 | 2009 |
| Bile acid derivatives as ligands of the farnesoid X receptor. Synthesis, evaluation, and structure-activity relationship of a series of body and side chain modified analogues … R Pellicciari, G Costantino, E Camaioni, BM Sadeghpour, A Entrena, ... Journal of medicinal chemistry 47 (18), 4559-4569, 2004 | 245 | 2004 |
| The farnesoid X receptor promotes adipocyte differentiation and regulates adipose cell function in vivo G Rizzo, M Disante, A Mencarelli, B Renga, A Gioiello, R Pellicciari, ... Molecular pharmacology 70 (4), 1164-1173, 2006 | 201 | 2006 |
| Bile acids signal via TGR5 to activate intestinal stem cells and epithelial regeneration G Sorrentino, A Perino, E Yildiz, G El Alam, MB Sleiman, A Gioiello, ... Gastroenterology 159 (3), 956-968. e8, 2020 | 189 | 2020 |
| Nongenomic actions of bile acids. Synthesis and preliminary characterization of 23-and 6, 23-alkyl-substituted bile acid derivatives as selective modulators for the G-protein … R Pellicciari, H Sato, A Gioiello, G Costantino, A Macchiarulo, ... Journal of medicinal chemistry 50 (18), 4265-4268, 2007 | 123 | 2007 |
| The medicinal chemistry in the era of machines and automation: recent advances in continuous flow technology A Gioiello, A Piccinno, AM Lozza, B Cerra Journal of medicinal chemistry 63 (13), 6624-6647, 2020 | 114 | 2020 |
| Progress and challenges of selective Farnesoid X Receptor modulation V Massafra, R Pellicciari, A Gioiello, SWC van Mil Pharmacology & therapeutics 191, 162-177, 2018 | 108 | 2018 |
| Europe PMC Funders Group TWH Pols, M Nomura, T Harach, GL Sasso, MH Oosterveer, C Thomas, ... Cell Metab 14 (6), 747-757, 2011 | 104* | 2011 |
| Recent advances in urea-and thiourea-containing compounds: focus on innovative approaches in medicinal chemistry and organic synthesis R Ronchetti, G Moroni, A Carotti, A Gioiello, E Camaioni RSC Medicinal Chemistry 12, 1046-1064, 2021 | 88 | 2021 |
| Determination of bile salt critical micellization concentration on the road to drug discovery B Natalini, R Sardella, A Gioiello, F Ianni, A Di Michele, M Marinozzi Journal of pharmaceutical and biomedical analysis 87, 62-81, 2014 | 83 | 2014 |
| Steroids interfere with human carbonic anhydrase activity by using alternative binding mechanisms A Nocentini, A Bonardi, P Gratteri, B Cerra, A Gioiello, CT Supuran Journal of enzyme inhibition and medicinal chemistry 33 (1), 1453-1459, 2018 | 78 | 2018 |
| SARS-CoV2 infection impairs the metabolism and redox function of cellular glutathione D Bartolini, AM Stabile, S Bastianelli, D Giustarini, S Pierucci, C Busti, ... Redox biology 45, 102041, 2021 | 71 | 2021 |
| Central anorexigenic actions of bile acids are mediated by TGR5 A Perino, LA Velázquez-Villegas, N Bresciani, Y Sun, Q Huang, ... Nature Metabolism 3 (5), 595-603, 2021 | 70 | 2021 |
| Building a Sulfonamide Library by Eco-Friendly Flow Synthesis A Gioiello, E Rosatelli, M Teofrasti, P Filipponi, R Pellicciari ACS combinatorial science 15 (5), 235-239, 2013 | 70 | 2013 |
| Back door modulation of the farnesoid X receptor: design, synthesis, and biological evaluation of a series of side chain modified chenodeoxycholic acid derivatives R Pellicciari, A Gioiello, G Costantino, BM Sadeghpour, G Rizzo, U Meyer, ... Journal of medicinal chemistry 49 (14), 4208-4215, 2006 | 67 | 2006 |
| Semisynthetic Bile Acid FXR and TGR5 Agonists: Physicochemical Properties, Pharmacokinetics, and Metabolism in the Rat A Roda, R Pellicciari, A Gioiello, F Neri, C Camborata, D Passeri, ... Journal of Pharmacology and Experimental Therapeutics 350 (1), 56-68, 2014 | 66 | 2014 |
| Extending SAR of bile acids as FXR ligands: Discovery of 23-N-(carbocinnamyloxy)-3α, 7α-dihydroxy-6α-ethyl-24-nor-5β-cholan-23-amine A Gioiello, A Macchiarulo, A Carotti, P Filipponi, G Costantino, G Rizzo, ... Bioorganic & medicinal chemistry 19 (8), 2650-2658, 2011 | 66 | 2011 |
