| Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases X Shang, F Marchioni, N Sipes, CR Evelyn, M Jerabek-Willemsen, S Duhr, ... Chemistry & biology 19 (6), 699-710, 2012 | 242 | 2012 |
| Small-molecule inhibitors targeting G-protein–coupled Rho guanine nucleotide exchange factors X Shang, F Marchioni, CR Evelyn, N Sipes, X Zhou, W Seibel, M Wortman, ... Proceedings of the National Academy of Sciences 110 (8), 3155-3160, 2013 | 161 | 2013 |
| New substituted 4H-chromenes as anticancer agents SA Patil, J Wang, XS Li, J Chen, TS Jones, A Hosni-Ahmed, R Patil, ... Bioorganic & medicinal chemistry letters 22 (13), 4458-4461, 2012 | 135 | 2012 |
| Compound C/dorsomorphin: its use and misuse as an AMPK inhibitor B Dasgupta, W Seibel AMPK: methods and protocols, 195-202, 2018 | 114 | 2018 |
| Small-molecule targeting of proliferating cell nuclear antigen chromatin association inhibits tumor cell growth Z Tan, M Wortman, KL Dillehay, WL Seibel, CR Evelyn, SJ Smith, ... Molecular pharmacology 81 (6), 811-819, 2012 | 111 | 2012 |
| Theoretical and practical considerations in virtual screening: a beaten field? M Kontoyianni, P Madhav, E Suchanek, W Seibel Current medicinal chemistry 15 (2), 107-116, 2008 | 85 | 2008 |
| Rational design of small molecule inhibitors targeting the Rac GTPase-p67phox signaling axis in inflammation EE Bosco, S Kumar, F Marchioni, J Biesiada, M Kordos, K Szczur, J Meller, ... Chemistry & biology 19 (2), 228-242, 2012 | 74 | 2012 |
| Rational design of small molecule inhibitors targeting the Ras GEF, SOS1 CR Evelyn, X Duan, J Biesiada, WL Seibel, J Meller, Y Zheng Chemistry & biology 21 (12), 1618-1628, 2014 | 70 | 2014 |
| Inhibition of the growth factor MDK/midkine by a novel small molecule compound to treat non-small cell lung cancer H Hao, Y Maeda, T Fukazawa, T Yamatsuji, M Takaoka, XH Bao, ... PloS one 8 (8), e71093, 2013 | 69 | 2013 |
| Hydroxylamines and sulfinamide as amine components in the Petasis boronic acid–Mannich reaction: Synthesis of N-hydroxy or alkoxy-α-aminocarboxylicacids and N-(tert-butyl … D Naskar, A Roy, WL Seibel, DE Portlock Tetrahedron letters 44 (49), 8865-8868, 2003 | 62 | 2003 |
| Ciprofloxacin is an inhibitor of the Mcm2-7 replicative helicase N Simon, ML Bochman, S Seguin, JL Brodsky, WL Seibel, A Schwacha Bioscience reports 33 (5), e00072, 2013 | 56 | 2013 |
| A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration Y Chen, Y Chen, B Jastrzebska, M Golczak, S Gulati, H Tang, W Seibel, ... Nature communications 9 (1), 1976, 2018 | 55 | 2018 |
| Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia X Jiang, C Hu, K Ferchen, J Nie, X Cui, CH Chen, L Cheng, Z Zuo, ... Nature communications 8 (1), 2099, 2017 | 54 | 2017 |
| Discovery of a novel class of potent HCV NS4B inhibitors: SAR studies on piperazinone derivatives R Kakarla, J Liu, D Naduthambi, W Chang, RT Mosley, D Bao, ... Journal of Medicinal Chemistry 57 (5), 2136-2160, 2014 | 54 | 2014 |
| Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface JI Fells, SC Lee, Y Fujiwara, DD Norman, KG Lim, R Tsukahara, J Liu, ... Molecular pharmacology 84 (3), 415-424, 2013 | 51 | 2013 |
| The synthesis of aza-β-lactams via tandem Petasis–Ugi multi-component condensation and 1, 3-diisopropylcarbodiimide (DIC) condensation reaction D Naskar, A Roy, WL Seibel, L West, DE Portlock Tetrahedron letters 44 (33), 6297-6300, 2003 | 51 | 2003 |
| Applications of solid supported azide anion: a one-pot, two-step preparation of functionalized 1, 2, 3-triazoles BE Blass, KR Coburn, AL Faulkner, WL Seibel, A Srivastava Tetrahedron letters 44 (10), 2153-2155, 2003 | 47 | 2003 |
| First stekeospecific synthesis of E-γ-bisabolene. A method for the concurrent generation of a ring and a tetrasubstituted exocyclic double bond. EJ Corey, WL Seibel Tetrahedron letters 27 (8), 905-908, 1986 | 47 | 1986 |
| Novel Petasis boronic acid–Mannich reactions with tertiary aromatic amines D Naskar, A Roy, WL Seibel, DE Portlock Tetrahedron letters 44 (31), 5819-5821, 2003 | 39 | 2003 |
| Discovery of (3S)-Amino-(4R)-ethylpiperidinyl Quinolones as Potent Antibacterial Agents with a Broad Spectrum of Activity and Activity against Resistant Pathogens XE Hu, NK Kim, JL Gray, JIK Almstead, WL Seibel, B Ledoussal Journal of medicinal chemistry 46 (17), 3655-3661, 2003 | 38 | 2003 |
