| RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins N Mailand, S Bekker-Jensen, H Faustrup, F Melander, J Bartek, C Lukas, ... Cell 131 (5), 887-900, 2007 | 1376 | 2007 |
| Site-specific integration in CHO cells mediated by CRISPR/Cas9 and homology-directed DNA repair pathway JS Lee, TB Kallehauge, LE Pedersen, HF Kildegaard Scientific reports 5, 8572, 2015 | 257 | 2015 |
| A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism H Hefzi, KS Ang, M Hanscho, A Bordbar, D Ruckerbauer, M Lakshmanan, ... Cell Systems 3 (5), 434-443. e8, 2016 | 253 | 2016 |
| Accelerating genome editing in CHO cells using CRISPR Cas9 and CRISPy, a web‐based target finding tool C Ronda, LE Pedersen, HG Hansen, TB Kallehauge, MJ Betenbaugh, ... Biotechnology and bioengineering 111 (8), 1604-1616, 2014 | 233 | 2014 |
| The emerging CHO systems biology era: harnessing the ‘omics revolution for biotechnology HF Kildegaard, D Baycin-Hizal, NE Lewis, MJ Betenbaugh Current opinion in biotechnology 24 (6), 1102-1107, 2013 | 202 | 2013 |
| Impact of CHO metabolism on cell growth and protein production: an overview of toxic and inhibiting metabolites and nutrients S Pereira, HF Kildegaard, MR Andersen Biotechnology journal 13 (3), 1700499, 2018 | 191 | 2018 |
| USP7 counteracts SCFβTrCP-but not APCCdh1-mediated proteolysis of Claspin H Faustrup, S Bekker-Jensen, J Bartek, J Lukas, N Mailand The Journal of cell biology 184 (1), 13-19, 2009 | 163 | 2009 |
| One‐step generation of triple knockout CHO cell lines using CRISPR/Cas9 and fluorescent enrichment LM Grav, JS Lee, S Gerling, TB Kallehauge, AH Hansen, S Kol, GM Lee, ... Biotechnology journal 10 (9), 1446-1456, 2015 | 161 | 2015 |
| CRISPR/Cas9‐mediated genome engineering of CHO cell factories: Application and perspectives JS Lee, LM Grav, NE Lewis, H Faustrup Kildegaard Biotechnology journal 10 (7), 979-994, 2015 | 145 | 2015 |
| Cell Factory Engineering AM Davy, HF Kildegaard, MR Andersen Cell Systems 4 (3), 262-275, 2017 | 140 | 2017 |
| Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion JM Gutierrez, A Feizi, S Li, TB Kallehauge, H Hefzi, LM Grav, D Ley, ... Nature Communications 11 (1), 1-10, 2020 | 118 | 2020 |
| A Markov chain model for N-linked protein glycosylation–towards a low-parameter tool for model-driven glycoengineering PN Spahn, AH Hansen, HG Hansen, J Arnsdorf, HF Kildegaard, NE Lewis Metabolic engineering 33, 52-66, 2016 | 107 | 2016 |
| Multiplex secretome engineering enhances recombinant protein production and purity S Kol, D Ley, T Wulff, M Decker, J Arnsdorf, S Schoffelen, AH Hansen, ... Nature communications 11 (1), 1-10, 2020 | 101 | 2020 |
| Glycoengineering of Chinese hamster ovary cells for enhanced erythropoietin N‐glycan branching and sialylation B Yin, Y Gao, C Chung, S Yang, E Blake, MC Stuczynski, J Tang, ... Biotechnology and bioengineering 112 (11), 2343-2351, 2015 | 100 | 2015 |
| Improving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions HG Hansen, N Pristovšek, HF Kildegaard, GM Lee Biotechnology advances 35 (1), 64-76, 2017 | 89 | 2017 |
| Accelerated homology‐directed targeted integration of transgenes in Chinese hamster ovary cells via CRISPR/Cas9 and fluorescent enrichment JS Lee, LM Grav, LE Pedersen, GM Lee, HF Kildegaard Biotechnology and bioengineering 113 (11), 2518-2523, 2016 | 87 | 2016 |
| Minimizing clonal variation during mammalian cell line engineering for improved systems biology data generation LM Grav, D Sergeeva, JS Lee, I Marin de Mas, NE Lewis, MR Andersen, ... ACS synthetic biology 7 (9), 2148-2159, 2018 | 76 | 2018 |
| Glycoprofiling effects of media additives on IgG produced by CHO cells in fed‐batch bioreactors HF Kildegaard, Y Fan, JW Sen, B Larsen, MR Andersen Biotechnology and bioengineering 113 (2), 359-366, 2016 | 72 | 2016 |
| Mitigating Clonal Variation in Recombinant Mammalian Cell Lines JS Lee, HF Kildegaard, NE Lewis, GM Lee Trends in biotechnology, 2019 | 66 | 2019 |
| Ribosome profiling-guided depletion of an mRNA increases cell growth rate and protein secretion TB Kallehauge, S Li, LE Pedersen, TK Ha, D Ley, MR Andersen, ... Scientific Reports 7, 40388, 2017 | 66 | 2017 |
