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Bruce Rogers
Bruce Rogers
Pfizer, University of California, University of Minnesota, Pharmacia, Morphic Therapeutic
Verificeret mail på morphictx.com
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Analysis of two carbon-13 NMR correlations for determining the stereochemistry of 1, 3-diol acetonides
SD Rychnovsky, B Rogers, G Yang
The Journal of Organic Chemistry 58 (13), 3511-3515, 1993
5491993
Configurational Assignment of Polyene Macrolide Antibiotics Using the [13C]Acetonide Analysis
SD Rychnovsky, BN Rogers, TI Richardson
Accounts of chemical research 31 (1), 9-17, 1998
3321998
Discovery and structure− activity relationship of quinuclidine benzamides as agonists of α7 nicotinic acetylcholine receptors
AL Bodnar, LA Cortes-Burgos, KK Cook, DM Dinh, VE Groppi, M Hajos, ...
Journal of medicinal chemistry 48 (4), 905-908, 2005
2682005
Discovery of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an Agonist of the α7 Nicotinic Acetylcholine Receptor, for the Potential …
DG Wishka, DP Walker, KM Yates, SC Reitz, S Jia, JK Myers, KL Olson, ...
Journal of medicinal chemistry 49 (14), 4425-4436, 2006
2382006
Design, synthesis, structure–activity relationship, and in vivo activity of azabicyclic aryl amides as α7 nicotinic acetylcholine receptor agonists
DP Walker, DG Wishka, DW Piotrowski, S Jia, SC Reitz, KM Yates, ...
Bioorganic & medicinal chemistry 14 (24), 8219-8248, 2006
1182006
Stereocontrolled synthesis of the tetracyclic core of the bisguanidine alkaloids Palau'amine and Styloguanidine
LE Overman, BN Rogers, JE Tellew, WC Trenkle
Journal of the American Chemical Society 119 (30), 7159-7160, 1997
1141997
Discovery of 4-(5-Methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a Novel α7 Nicotinic Acetylcholine Receptor Agonist for the …
CJ O’Donnell, BN Rogers, BS Bronk, DK Bryce, JW Coe, KK Cook, ...
Journal of medicinal chemistry 53 (3), 1222-1237, 2010
972010
Discovery of N-[(3R, 5R)-1-azabicyclo [3.2. 1] oct-3-yl] furo [2, 3-c] pyridine-5-carboxamide as an agonist of the α7 nicotinic acetylcholine receptor: In vitro and in vivo …
BA Acker, EJ Jacobsen, BN Rogers, DG Wishka, SC Reitz, DW Piotrowski, ...
Bioorganic & Medicinal Chemistry Letters 18 (12), 3611-3615, 2008
952008
Targeting α7 nicotinic acetylcholine receptors in the treatment of schizophrenia
M Hajós, BN Rogers
Current pharmaceutical design 16 (5), 538-554, 2010
922010
Discovery of trifluoromethyl glycol carbamates as potent and selective covalent monoacylglycerol lipase (MAGL) inhibitors for treatment of neuroinflammation
LA McAllister, CR Butler, S Mente, SV O’Neil, KR Fonseca, JR Piro, ...
Journal of medicinal chemistry 61 (7), 3008-3026, 2018
732018
Utilizing structures of CYP2D6 and BACE1 complexes to reduce risk of drug–drug interactions with a novel series of centrally efficacious BACE1 inhibitors
MA Brodney, EM Beck, CR Butler, G Barreiro, EF Johnson, D Riddell, ...
Journal of medicinal chemistry 58 (7), 3223-3252, 2015
712015
Utilizing structures of CYP2D6 and BACE1 complexes to reduce risk of drug–drug interactions with a novel series of centrally efficacious BACE1 inhibitors
MA Brodney, EM Beck, CR Butler, G Barreiro, EF Johnson, D Riddell, ...
Journal of medicinal chemistry 58 (7), 3223-3252, 2015
712015
Tetracyclic azepinoindole compounds
JB Hester, BN Rogers, EJ Jacobsen, MD Ennis, BA Acker, ...
US Patent 6,407,092, 2002
702002
An efficient assembly of heterobenzazepine ring systems utilizing an intramolecular palladium-catalyzed cycloamination
BJ Margolis, JJ Swidorski, BN Rogers
The Journal of Organic Chemistry 68 (2), 644-647, 2003
692003
Quinuclidine-substituted heteroaryl moieties for treatment of disease
JK Myers, BN Rogers, VE Groppi Jr, DW Piotrowski, AL Bodnar, ...
US Patent 6,492,385, 2002
672002
Stereocontrolled Synthesis of Triazacyclopenta[cd]pentalenes by Intramolecular 1,3-Dipolar Cycloaddition Reactions of Azomethine Imines
G Bélanger, FT Hong, LE Overman, BN Rogers, JE Tellew, WC Trenkle
The Journal of Organic Chemistry 67 (22), 7880-7883, 2002
672002
Azetidine and piperidine carbamates as efficient, covalent inhibitors of monoacylglycerol lipase
CR Butler, EM Beck, A Harris, Z Huang, LA McAllister, CW Am Ende, ...
Journal of Medicinal Chemistry 60 (23), 9860-9873, 2017
652017
Discovery and Preclinical Characterization of 1-Methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1H-pyrazolo-[3,4-b]pyrazine (PF470): A Highly Potent …
L Zhang, G Balan, G Barreiro, BP Boscoe, LK Chenard, J Cianfrogna, ...
Journal of medicinal chemistry 57 (3), 861-877, 2014
582014
Quinuclidine-substituted heteroaryl moieties for treatment of disease
JK Myers, BN Rogers, VE Groppi Jr, DW Piotrowski, AL Bodnar, ...
US Patent 6,500,840, 2002
562002
Two-dimensional NMR analysis of acetonide derivatives in the stereochemical assignment of polyol chains: the absolute configurations of dermostatins A and B
SD Rychnovsky, TI Richardson, BN Rogers
The Journal of Organic Chemistry 62 (9), 2925-2934, 1997
461997
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