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Brahim Achour
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Expression of hepatic drug-metabolizing cytochrome p450 enzymes and their intercorrelations: a meta-analysis
B Achour, J Barber, A Rostami-Hodjegan
Drug Metabolism and Disposition 42 (8), 1349-1356, 2014
2372014
Simultaneous quantification of the abundance of several cytochrome P450 and uridine 5'-diphospho-glucuronosyltransferase enzymes in human liver microsomes using multiplexed …
B Achour, MR Russell, J Barber, A Rostami-Hodjegan
Drug Metabolism and Disposition 42 (4), 500-510, 2014
1832014
Variability in mass spectrometry-based quantification of clinically relevant drug transporters and drug metabolizing enzymes
C Wegler, FZ Gaugaz, TB Andersson, JR Wiśniewski, D Busch, C Gröer, ...
Molecular Pharmaceutics 14 (9), 3142-3151, 2017
1112017
Model-Informed Precision Dosing: Background, Requirements, Validation, Implementation, and Forward Trajectory of Individualizing Drug Therapy
AS Darwich, TM Polasek, JK Aronson, K Ogungbenro, DFB Wright, ...
Annual Review of Pharmacology and Toxicology 61 (1), 225-245, 2021
972021
Toward a Consensus on Applying Quantitative Liquid Chromatography‐Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper
B Prasad, B Achour, P Artursson, CECA Hop, Y Lai, PC Smith, J Barber, ...
Clinical Pharmacology & Therapeutics 106 (3), 525-543, 2019
962019
Proteomic quantification of human blood–brain barrier SLC and ABC transporters in healthy individuals and dementia patients
ZM Al-Majdoub, H Al Feteisi, B Achour, S Warwood, S Neuhoff, ...
Molecular Pharmaceutics 16 (3), 1220-1233, 2019
952019
Meta-analysis of expression of hepatic organic anion–transporting polypeptide (OATP) transporters in cellular systems relative to human liver tissue
J Badée, B Achour, A Rostami-Hodjegan, A Galetin
Drug Metabolism and Disposition 43 (4), 424-432, 2015
952015
Cytochrome P450 pig liver pie: determination of individual cytochrome P450 isoform contents in microsomes from two pig livers using liquid chromatography in conjunction with …
B Achour, J Barber, A Rostami-Hodjegan
Drug Metabolism and Disposition 39 (11), 2130-2134, 2011
942011
Quantitative proteomics of clinically relevant drug-metabolizing enzymes and drug transporters and their intercorrelations in the human small intestine
N Couto, ZM Al-Majdoub, S Gibson, PJ Davies, B Achour, MD Harwood, ...
Drug Metabolism and Disposition 48 (4), 245-254, 2020
852020
Quantification of proteins involved in drug metabolism and disposition in the human liver using label-free global proteomics
N Couto, ZM Al-Majdoub, B Achour, PC Wright, A Rostami-Hodjegan, ...
Molecular Pharmaceutics 16 (2), 632-647, 2019
702019
Identification and quantification of blood–brain barrier transporters in isolated rat brain microvessels
H Al Feteisi, ZM Al‐Majdoub, B Achour, N Couto, A Rostami‐Hodjegan, ...
Journal of Neurochemistry 146 (6), 670-685, 2018
702018
Application of an LC–MS/MS method for the simultaneous quantification of human intestinal transporter proteins absolute abundance using a QconCAT technique
MD Harwood, B Achour, MR Russell, GL Carlson, G Warhurst, ...
Journal of Pharmaceutical and Biomedical Analysis 110, 27-33, 2015
652015
Alternative fusion protein strategies to express recalcitrant QconCAT proteins for quantitative proteomics of human drug metabolizing enzymes and transporters
MR Russell, B Achour, EA Mckenzie, R Lopez, MD Harwood, ...
Journal of Proteome Research 12 (12), 5934-5942, 2013
642013
Liquid Biopsy Enables Quantification of the Abundance and Interindividual Variability of Hepatic Enzymes and Transporters
B Achour, ZM Al‐Majdoub, A Grybos‐Gajniak, K Lea, P Kilford, M Zhang, ...
Clinical Pharmacology & Therapeutics 109 (1), 222-232, 2021
622021
In vitro–in vivo extrapolation scaling factors for intestinal P-glycoprotein and breast cancer resistance protein: part I: a cross-laboratory comparison of transporter-protein …
MD Harwood, B Achour, S Neuhoff, MR Russell, G Carlson, G Warhurst, ...
Drug Metabolism and Disposition 44 (3), 297-307, 2016
552016
Quantitative characterization of major hepatic UDP-glucuronosyltransferase enzymes in human liver microsomes: comparison of two proteomic methods and correlation with catalytic …
B Achour, A Dantonio, M Niosi, JJ Novak, JK Fallon, J Barber, PC Smith, ...
Drug Metabolism and Disposition 45 (10), 1102-1112, 2017
532017
Protein expression of various hepatic uridine 5′‐diphosphate glucuronosyltransferase (UGT) enzymes and their inter‐correlations: a meta‐analysis
B Achour, A Rostami‐Hodjegan, J Barber
Biopharmaceutics and Drug Disposition 35 (6), 353-361, 2014
532014
Choice of LC-MS methods for the absolute quantification of drug-metabolizing enzymes and transporters in human tissue: a comparative cost analysis
H Al Feteisi, B Achour, J Barber, A Rostami-Hodjegan
The AAPS Journal 17 (2), 438-446, 2015
482015
Global Proteomic Analysis of Human Liver Microsomes: Rapid Characterization and Quantification of Hepatic Drug-Metabolizing Enzymes
B Achour, H Al-Feteisi, F Lanucara, A Rostami-Hodjegan, J Barber
Drug Metabolism and Disposition 45 (6), 666-675, 2017
462017
Non-uniformity of changes in drug-metabolizing enzymes and transporters in liver cirrhosis: implications for drug dosage adjustment
E El-Khateeb, B Achour, ZM Al-Majdoub, J Barber, A Rostami-Hodjegan
Molecular pharmaceutics 18 (9), 3563-3577, 2021
392021
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