David CS Huang
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ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
AJ Souers, JD Leverson, ER Boghaert, SL Ackler, ND Catron, J Chen, ...
Nature medicine 19 (2), 202-208, 2013
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
L Chen, SN Willis, A Wei, BJ Smith, JI Fletcher, MG Hinds, PM Colman, ...
Molecular cell 17 (3), 393-403, 2005
The Bcl-2 family: roles in cell survival and oncogenesis
S Cory, D Huang, JM Adams
Oncogene 22 (53), 8590-8607, 2003
Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
P Bouillet, D Metcalf, DCS Huang, DM Tarlinton, TWH Kay, F Kontgen, ...
Science 286 (5445), 1735-1738, 1999
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
SN Willis, L Chen, G Dewson, A Wei, E Naik, JI Fletcher, JM Adams, ...
Genes & development 19 (11), 1294-1305, 2005
Bim: a novel member of the Bcl‐2 family that promotes apoptosis
L O'Connor, A Strasser, LA O'Reilly, G Hausmann, JM Adams, S Cory, ...
The EMBO journal, 1998
The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex
H Puthalakath, DCS Huang, LA O’Reilly, SM King, A Strasser
Molecular cell 3 (3), 287-296, 1999
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
SN Willis, JI Fletcher, T Kaufmann, MF van Delft, L Chen, PE Czabotar, ...
Science 315 (5813), 856-859, 2007
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
MF Van Delft, AH Wei, KD Mason, CJ Vandenberg, L Chen, PE Czabotar, ...
Cancer cell 10 (5), 389-399, 2006
BH3-only proteins—essential initiators of apoptotic cell death
DCS Huang, A Strasser
Cell 103 (6), 839-842, 2000
Programmed anuclear cell death delimits platelet life span
KD Mason, MR Carpinelli, JI Fletcher, JE Collinge, AA Hilton, S Ellis, ...
Cell 128 (6), 1173-1186, 2007
The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models
A Kotschy, Z Szlavik, J Murray, J Davidson, AL Maragno, ...
Nature 538 (7626), 477-482, 2016
Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease
AW Roberts, JF Seymour, JR Brown, WG Wierda, TJ Kipps, SL Khaw, ...
Journal of Clinical Oncology 30 (5), 488, 2012
Bcl‐2 and Fas/APO‐1 regulate distinct pathways to lymphocyte apoptosis.
A Strasser, AW Harris, DC Huang, PH Krammer, S Cory
The EMBO journal 14 (24), 6136-6147, 1995
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7
IE Wertz, S Kusam, C Lam, T Okamoto, W Sandoval, DJ Anderson, ...
Nature 471 (7336), 110-114, 2011
Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis
H Puthalakath, A Villunger, LA O'Reilly, JG Beaumont, L Coultas, ...
Science 293 (5536), 1829-1832, 2001
Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production
MJ White, K McArthur, D Metcalf, RM Lane, JC Cambier, MJ Herold, ...
Cell 159 (7), 1549-1562, 2014
Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival
M Schwickart, XD Huang, JR Lill, J Liu, R Ferrando, DM French, ...
Nature 463 (7277), 103-107, 2010
Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome
VS Marsden, L O'Connor, LA O'Reilly, J Silke, D Metcalf, PG Ekert, ...
Nature 419 (6907), 634-637, 2002
Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis
PE Czabotar, D Westphal, G Dewson, S Ma, C Hockings, WD Fairlie, ...
Cell 152 (3), 519-531, 2013
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