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David CS Huang
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ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
AJ Souers, JD Leverson, ER Boghaert, SL Ackler, ND Catron, J Chen, ...
Nature medicine 19 (2), 202-208, 2013
32292013
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
L Chen, SN Willis, A Wei, BJ Smith, JI Fletcher, MG Hinds, PM Colman, ...
Molecular cell 17 (3), 393-403, 2005
22792005
The Bcl-2 family: roles in cell survival and oncogenesis
S Cory, D Huang, JM Adams
Oncogene 22 (53), 8590-8607, 2003
21342003
Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
P Bouillet, D Metcalf, DCS Huang, DM Tarlinton, TWH Kay, F Kontgen, ...
Science 286 (5445), 1735-1738, 1999
19131999
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
SN Willis, L Chen, G Dewson, A Wei, E Naik, JI Fletcher, JM Adams, ...
Genes & development 19 (11), 1294-1305, 2005
16172005
Bim: a novel member of the Bcl‐2 family that promotes apoptosis
L O'Connor, A Strasser, LA O'Reilly, G Hausmann, JM Adams, S Cory, ...
The EMBO journal, 1998
14961998
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
MF Van Delft, AH Wei, KD Mason, CJ Vandenberg, L Chen, PE Czabotar, ...
Cancer cell 10 (5), 389-399, 2006
14802006
The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex
H Puthalakath, DCS Huang, LA O’Reilly, SM King, A Strasser
Molecular cell 3 (3), 287-296, 1999
14761999
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
SN Willis, JI Fletcher, T Kaufmann, MF van Delft, L Chen, PE Czabotar, ...
Science 315 (5813), 856-859, 2007
14752007
BH3-only proteins—essential initiators of apoptotic cell death
DCS Huang, A Strasser
Cell 103 (6), 839-842, 2000
14202000
Programmed anuclear cell death delimits platelet life span
KD Mason, MR Carpinelli, JI Fletcher, JE Collinge, AA Hilton, S Ellis, ...
Cell 128 (6), 1173-1186, 2007
12412007
The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models
A Kotschy, Z Szlavik, J Murray, J Davidson, AL Maragno, ...
Nature 538 (7626), 477-482, 2016
10722016
Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease
AW Roberts, JF Seymour, JR Brown, WG Wierda, TJ Kipps, SL Khaw, ...
Journal of Clinical Oncology 30 (5), 488-496, 2012
9632012
Bcl‐2 and Fas/APO‐1 regulate distinct pathways to lymphocyte apoptosis.
A Strasser, AW Harris, DC Huang, PH Krammer, S Cory
The EMBO journal 14 (24), 6136-6147, 1995
9451995
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7
IE Wertz, S Kusam, C Lam, T Okamoto, W Sandoval, DJ Anderson, ...
Nature 471 (7336), 110-114, 2011
8992011
Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production
MJ White, K McArthur, D Metcalf, RM Lane, JC Cambier, MJ Herold, ...
Cell 159 (7), 1549-1562, 2014
8932014
Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis
H Puthalakath, A Villunger, LA O'Reilly, JG Beaumont, L Coultas, ...
Science 293 (5536), 1829-1832, 2001
8372001
Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival
M Schwickart, XD Huang, JR Lill, J Liu, R Ferrando, DM French, ...
Nature 463 (7277), 103-107, 2010
7352010
Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome
VS Marsden, L O'Connor, LA O'Reilly, J Silke, D Metcalf, PG Ekert, ...
Nature 419 (6907), 634-637, 2002
7262002
Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis
PE Czabotar, D Westphal, G Dewson, S Ma, C Hockings, WD Fairlie, ...
Cell 152 (3), 519-531, 2013
6602013
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