| Intratumor heterogeneity and branched evolution revealed by multiregion sequencing M Gerlinger, AJ Rowan, S Horswell, J Larkin, D Endesfelder, E Gronroos, ... New England journal of medicine 366 (10), 883-892, 2012 | 8512 | 2012 |
| Targeting RAS signalling pathways in cancer therapy J Downward Nature reviews cancer 3 (1), 11-22, 2003 | 4288 | 2003 |
| Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells A Ullrich, L Coussens, JS Hayflick, TJ Dull, A Gray, AW Tam, J Lee, ... Nature 309 (5967), 418-425, 1984 | 3467 | 1984 |
| Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences J Downward, Y Yarden, E Mayes, G Scrace, N Totty, P Stockwell, A Ullrich, ... Nature 307 (5951), 521-527, 1984 | 3327 | 1984 |
| Phosphatidylinositol-3-OH kinase as a direct target of Ras P Rodriguez-Viciana, PH Warne, R Dhand, B Vanhaesebroeck, I Gout, ... Nature 370 (6490), 527-532, 1994 | 2670 | 1994 |
| Mechanisms and consequences of activation of protein kinase B/Akt J Downward Current opinion in cell biology 10 (2), 262-267, 1998 | 1712 | 1998 |
| Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor L Buday, J Downward Cell 73 (3), 611-620, 1993 | 1522 | 1993 |
| Suppression of c-Myc-induced apoptosis by Ras signalling through PI (3) K and PKB A Kauffmann-Zeh, P Rodriguez-Viciana, E Ulrich, C Gilbert, P Coffer, ... Nature 385 (6616), 544-548, 1997 | 1499 | 1997 |
| Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras P Rodriguez-Viciana, PH Warne, A Khwaja, BM Marte, D Pappin, P Das, ... Cell 89 (3), 457-467, 1997 | 1356 | 1997 |
| Matrix adhesion and Ras transformation both activate a phosphoinositide 3‐OH kinase and protein kinase B/Akt cellular survival pathway A Khwaja, P Rodriguez‐Viciana, S Wennström, PH Warne, J Downward The EMBO journal, 1997 | 1302 | 1997 |
| Stimulation of p21ras upon T-cell activation J Downward, JD Graves, PH Warne, S Rayter, DA Cantrell Nature 346 (6286), 719-723, 1990 | 1093 | 1990 |
| PI 3-kinase, Akt and cell survival J Downward Seminars in cell & developmental biology 15 (2), 177-182, 2004 | 1042 | 2004 |
| Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis S Basu, NF Totty, MS Irwin, M Sudol, J Downward Molecular cell 11 (1), 11-23, 2003 | 1002 | 2003 |
| Autophosphorylation sites on the epidermal growth factor receptor J Downward, P Parker, MD Waterfield Nature 311 (5985), 483-485, 1984 | 960 | 1984 |
| Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro PH Warne, PR Vician, J Downward Nature 364 (6435), 352-355, 1993 | 959 | 1993 |
| Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways E Janda, K Lehmann, I Killisch, M Jechlinger, M Herzig, J Downward, ... The Journal of cell biology 156 (2), 299-314, 2002 | 949 | 2002 |
| PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond BM Marte, J Downward Trends in biochemical sciences 22 (9), 355-358, 1997 | 942 | 1997 |
| RAS interaction with PI3K: more than just another effector pathway E Castellano, J Downward Genes & cancer 2 (3), 261-274, 2011 | 899 | 2011 |
| Navigating gene expression using microarrays? a technology review. A Schulze, J Downward Nature cell biology 3 (8), 2001 | 832 | 2001 |
| Expression cloning and characterization of the TGF-β type III receptor XF Wang, HY Lin, E Ng-Eaton, J Downward, HF Lodish, RA Weinberg Cell 67 (4), 797-805, 1991 | 820 | 1991 |
