Interleukin-18 inhibits hepatitis B virus replication in the livers of transgenic mice K Kimura, K Kakimi, S Wieland, LG Guidotti, FV Chisari Journal of virology 76 (21), 10702-10707, 2002 | 256 | 2002 |
Activated intrahepatic antigen-presenting cells inhibit hepatitis B virus replication in the liver of transgenic mice K Kimura, K Kakimi, S Wieland, LG Guidotti, FV Chisari The Journal of Immunology 169 (9), 5188-5195, 2002 | 175 | 2002 |
Wnt/β-catenin signaling as a potential target for the treatment of liver cirrhosis using antifibrotic drugs K Nishikawa, Y Osawa, K Kimura International journal of molecular sciences 19 (10), 3103, 2018 | 121 | 2018 |
Safety, tolerability, and preliminary efficacy of the anti-fibrotic small molecule PRI-724, a CBP/β-catenin inhibitor, in patients with hepatitis C virus-related cirrhosis: a … K Kimura, A Ikoma, M Shibakawa, S Shimoda, K Harada, M Saio, ... EBioMedicine 23, 79-87, 2017 | 92 | 2017 |
Immunopathogenesis of hepatic fibrosis in chronic liver injury induced by repeatedly administered concanavalin A K Kimura, K Ando, H Ohnishi, T Ishikawa, S Kakumu, M Takemura, Y Muto, ... International immunology 11 (9), 1491-1500, 1999 | 85 | 1999 |
Inhibition of cyclic adenosine monophosphate (cAMP)-response element-binding protein (CREB)-binding protein (CBP)/β-catenin reduces liver fibrosis in mice Y Osawa, K Oboki, J Imamura, E Kojika, Y Hayashi, T Hishima, T Saibara, ... EBioMedicine 2 (11), 1751-1758, 2015 | 84 | 2015 |
Selective inhibitor of Wnt/β-catenin/CBP signaling ameliorates hepatitis C virus-induced liver fibrosis in mouse model Y Tokunaga, Y Osawa, T Ohtsuki, Y Hayashi, K Yamaji, D Yamane, ... Scientific reports 7 (1), 325, 2017 | 78 | 2017 |
Leflunomide protects from T‐cell–mediated liver injury in mice through inhibition of nuclear factor κB M Imose, M Nagaki, K Kimura, S Takai, M Imao, T Naiki, Y Osawa, ... Hepatology 40 (5), 1160-1169, 2004 | 71 | 2004 |
Pathogenic role of B cells in anti-CD40-induced necroinflammatory liver disease K Kimura, H Moriwaki, M Nagaki, M Saio, Y Nakamoto, M Naito, K Kuwata, ... The American journal of pathology 168 (3), 786-795, 2006 | 44 | 2006 |
Blockade of neutrophil elastase attenuates severe liver injury in hepatitis B transgenic mice S Takai, K Kimura, M Nagaki, S Satake, K Kakimi, H Moriwaki Journal of virology 79 (24), 15142-15150, 2005 | 39 | 2005 |
IL-12 induces specific cytotoxicity against regenerating hepatocytes in vivo T Matsushita, K Ando, K Kimura, H Ohnishi, M Imawari, Y Muto, ... International immunology 11 (5), 657-665, 1999 | 39 | 1999 |
Granulocyte colony-stimulating factor impairs liver regeneration in mice through the up-regulation of interleukin-1β T Ogiso, M Nagaki, S Takai, Y Tsukada, T Mukai, K Kimura, H Moriwaki Journal of hepatology 47 (6), 816-825, 2007 | 38 | 2007 |
Elevated intracellular IFN-γ levels in circulating CD8+ lymphocytes in patients with fulminant hepatitis K Kimura, K Ando, E Tomita, H Ohnishi, T Ishikawa, S Kakumu, Y Muto, ... Journal of hepatology 31 (4), 579-583, 1999 | 38 | 1999 |
Pivotal role of nuclear factor κB signaling in anti‐CD40–induced liver injury in mice K Kimura, M Nagaki, S Takai, S Satake, H Moriwaki Hepatology 40 (5), 1180-1189, 2004 | 33 | 2004 |
Tumor necrosis factor‐α‐mediated hepatocyte apoptosis stimulates fibrosis in the steatotic liver in mice Y Osawa, E Kojika, Y Hayashi, M Kimura, K Nishikawa, S Yoshio, H Doi, ... Hepatology communications 2 (4), 407-420, 2018 | 30 | 2018 |
Role of macrophage migration inhibitory factor in hepatitis B virus-specific cytotoxic-T-lymphocyte-induced liver injury K Kimura, M Nagaki, J Nishihira, S Satake, K Kuwata, H Moriwaki Clinical and vaccine immunology 13 (3), 415-419, 2006 | 30 | 2006 |
M2 macrophages play critical roles in progression of inflammatory liver disease in hepatitis C virus transgenic mice T Ohtsuki, K Kimura, Y Tokunaga, K Tsukiyama-Kohara, C Tateno, ... Journal of virology 90 (1), 300-307, 2016 | 27 | 2016 |
Kinetics of peripheral hepatitis B virus-specific CD8+ T cells in patients with onset of viral reactivation J Aoki, Y Kowazaki, T Ohtsuki, R Okamoto, K Ohashi, S Hayashi, ... Journal of gastroenterology 48, 728-737, 2013 | 26 | 2013 |
Critical role of CD44 in hepatotoxin-mediated liver injury K Kimura, M Nagaki, K Kakimi, M Saio, T Saeki, Y Okuda, K Kuwata, ... Journal of hepatology 48 (6), 952-961, 2008 | 26 | 2008 |
Immunization with a recombinant vaccinia virus that encodes nonstructural proteins of the hepatitis C virus suppresses viral protein levels in mouse liver S Sekiguchi, K Kimura, T Chiyo, T Ohtsuki, Y Tobita, Y Tokunaga, F Yasui, ... PloS one 7 (12), e51656, 2012 | 23 | 2012 |