Nicholas McGranahan
Nicholas McGranahan
Group Leader, CRUK Lung Cancer Centre of Excellence, UCL Cancer Institute
Verified email at ucl.ac.uk - Homepage
Title
Cited by
Cited by
Year
The causes and consequences of genetic heterogeneity in cancer evolution
RA Burrell, N McGranahan, J Bartek, C Swanton
Nature 501 (7467), 338-345, 2013
16592013
Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade
N McGranahan, AJS Furness, R Rosenthal, S Ramskov, R Lyngaa, ...
Science 351 (6280), 1463-1469, 2016
15552016
Tracking the evolution of non–small-cell lung cancer
M Jamal-Hanjani, GA Wilson, N McGranahan, NJ Birkbak, TBK Watkins, ...
New England Journal of Medicine 376 (22), 2109-2121, 2017
10242017
Clonal heterogeneity and tumor evolution: past, present, and the future
N McGranahan, C Swanton
Cell 168 (4), 613-628, 2017
9972017
Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing
M Gerlinger, S Horswell, J Larkin, AJ Rowan, MP Salm, I Varela, R Fisher, ...
Nature genetics 46 (3), 225, 2014
9862014
Spatial and temporal diversity in genomic instability processes defines lung cancer evolution
EC de Bruin, N McGranahan, R Mitter, M Salm, DC Wedge, L Yates, ...
Science 346 (6206), 251-256, 2014
8362014
Biological and therapeutic impact of intratumor heterogeneity in cancer evolution
N McGranahan, C Swanton
Cancer cell 27 (1), 15-26, 2015
7392015
Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution
C Abbosh, NJ Birkbak, GA Wilson, M Jamal-Hanjani, T Constantin, ...
Nature 545 (7655), 446-451, 2017
6702017
DeconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution
R Rosenthal, N McGranahan, J Herrero, BS Taylor, C Swanton
Genome biology 17 (1), 1-11, 2016
4752016
Clonal status of actionable driver events and the timing of mutational processes in cancer evolution
N McGranahan, F Favero, EC de Bruin, NJ Birkbak, Z Szallasi, C Swanton
Science translational medicine 7 (283), 283ra54-283ra54, 2015
4052015
Allele-specific HLA loss and immune escape in lung cancer evolution
N McGranahan, R Rosenthal, CT Hiley, AJ Rowan, TBK Watkins, ...
Cell 171 (6), 1259-1271. e11, 2017
3702017
Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis
S Turajlic, K Litchfield, H Xu, R Rosenthal, N McGranahan, JL Reading, ...
The lancet oncology 18 (8), 1009-1021, 2017
3642017
Genomic features of response to combination immunotherapy in patients with advanced non-small-cell lung cancer
MD Hellmann, T Nathanson, H Rizvi, BC Creelan, F Sanchez-Vega, ...
Cancer cell 33 (5), 843-852. e4, 2018
3612018
Chromosomal instability drives metastasis through a cytosolic DNA response
SF Bakhoum, B Ngo, AM Laughney, JA Cavallo, CJ Murphy, P Ly, P Shah, ...
Nature 553 (7689), 467-472, 2018
3422018
Cancer chromosomal instability: therapeutic and diagnostic challenges: ‘Exploring aneuploidy: the significance of chromosomal imbalance’review series
N McGranahan, RA Burrell, D Endesfelder, MR Novelli, C Swanton
EMBO reports 13 (6), 528-538, 2012
3052012
APOBEC enzymes: mutagenic fuel for cancer evolution and heterogeneity
C Swanton, N McGranahan, GJ Starrett, RS Harris
Cancer discovery 5 (7), 704-712, 2015
2662015
Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution
SM Dewhurst, N McGranahan, RA Burrell, AJ Rowan, E Grönroos, ...
Cancer discovery 4 (2), 175-185, 2014
2252014
Deterministic evolutionary trajectories influence primary tumor growth: TRACERx renal
S Turajlic, H Xu, K Litchfield, A Rowan, S Horswell, T Chambers, ...
Cell 173 (3), 595-610. e11, 2018
2132018
Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers
CM Blakely, TBK Watkins, W Wu, B Gini, JJ Chabon, CE McCoach, ...
Nature genetics 49 (12), 1693-1704, 2017
2092017
Fc effector function contributes to the activity of human anti-CTLA-4 antibodies
FA Vargas, AJS Furness, K Litchfield, K Joshi, R Rosenthal, E Ghorani, ...
Cancer cell 33 (4), 649-663. e4, 2018
1942018
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