| H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers M Seiler, A Yoshimi, R Darman, B Chan, G Keaney, M Thomas, ... Nature medicine 24 (4), 497-504, 2018 | 494 | 2018 |
| Cancer-associated SF3B1 hotspot mutations induce cryptic 3′ splice site selection through use of a different branch point RB Darman, M Seiler, AA Agrawal, KH Lim, S Peng, D Aird, SL Bailey, ... Cell reports 13 (5), 1033-1045, 2015 | 475 | 2015 |
| Somatic mutational landscape of splicing factor genes and their functional consequences across 33 cancer types M Seiler, S Peng, AA Agrawal, J Palacino, T Teng, P Zhu, PG Smith, ... Cell reports 23 (1), 282-296. e4, 2018 | 406 | 2018 |
| Physiologic expression of Sf3b1K700E causes impaired erythropoiesis, aberrant splicing, and sensitivity to therapeutic spliceosome modulation EA Obeng, RJ Chappell, M Seiler, MC Chen, DR Campagna, PJ Schmidt, ... Cancer cell 30 (3), 404-417, 2016 | 390 | 2016 |
| Molecular stratification of clear cell renal cell carcinoma by consensus clustering reveals distinct subtypes and survival patterns AR Brannon, A Reddy, M Seiler, A Arreola, DT Moore, RS Pruthi, ... Genes & cancer 1 (2), 152-163, 2010 | 358 | 2010 |
| Identifying mRNA targets of microRNA dysregulated in cancer: with application to clear cell Renal Cell Carcinoma H Liu, AR Brannon, AR Reddy, G Alexe, MW Seiler, A Arreola, JH Oza, ... BMC systems biology 4, 1-17, 2010 | 317 | 2010 |
| Transcriptomic characterization of SF3B1 mutation reveals its pleiotropic effects in chronic lymphocytic leukemia L Wang, AN Brooks, J Fan, Y Wan, R Gambe, S Li, S Hergert, S Yin, ... Cancer cell 30 (5), 750-763, 2016 | 223 | 2016 |
| Synthetic lethal and convergent biological effects of cancer-associated spliceosomal gene mutations SCW Lee, K North, E Kim, E Jang, E Obeng, SX Lu, B Liu, D Inoue, ... Cancer cell 34 (2), 225-241. e8, 2018 | 217 | 2018 |
| Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex T Teng, JHC Tsai, X Puyang, M Seiler, S Peng, S Prajapati, D Aird, ... Nature communications 8 (1), 15522, 2017 | 147 | 2017 |
| Hemopoietic-specific Sf3b1-K700E knock-in mice display the splicing defect seen in human MDS but develop anemia without ring sideroblasts A Mupo, M Seiler, V Sathiaseelan, A Pance, Y Yang, AA Agrawal, F Iorio, ... Leukemia 31 (3), 720-727, 2017 | 142 | 2017 |
| Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer M Korpal, X Puyang, Z Jeremy Wu, R Seiler, C Furman, HZ Oo, M Seiler, ... Nature communications 8 (1), 103, 2017 | 134 | 2017 |
| Genome-wide CRISPR-Cas9 screen identifies leukemia-specific dependence on a pre-mRNA metabolic pathway regulated by DCPS T Yamauchi, T Masuda, MC Canver, M Seiler, Y Semba, M Shboul, ... Cancer cell 33 (3), 386-400. e5, 2018 | 132 | 2018 |
| Identifying microRNA/mRNA dysregulations in ovarian cancer GD Miles, M Seiler, L Rodriguez, G Rajagopal, G Bhanot BMC research notes 5, 1-10, 2012 | 131 | 2012 |
| ConsensusCluster: a software tool for unsupervised cluster discovery in numerical data M Seiler, CC Huang, S Szalma, G Bhanot OMICS A Journal of Integrative Biology 14 (1), 109-113, 2010 | 102 | 2010 |
| SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4 K Tzelepis, E De Braekeleer, D Aspris, I Barbieri, MS Vijayabaskar, ... Nature communications 9 (1), 5378, 2018 | 72 | 2018 |
| Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators D Aird, T Teng, CL Huang, E Pazolli, D Banka, K Cheung-Ong, C Eifert, ... Nature communications 10 (1), 137, 2019 | 69 | 2019 |
| Lactase persistence and lipid pathway selection in the Maasai K Wagh, A Bhatia, G Alexe, A Reddy, V Ravikumar, M Seiler, M Boemo, ... Public Library of Science 7 (9), e44751, 2012 | 69 | 2012 |
| Sex-Biased ZRSR2 Mutations in Myeloid Malignancies Impair Plasmacytoid Dendritic Cell Activation and Apoptosis K Togami, SS Chung, V Madan, CAG Booth, CM Kenyon, L Cabal-Hierro, ... Cancer discovery 12 (2), 522-541, 2022 | 66 | 2022 |
| Towards improved cancer diagnosis and prognosis using analysis of gene expression data and computer aided imaging G Alexe, J Monaco, S Doyle, A Basavanhally, A Reddy, M Seiler, ... Experimental Biology and Medicine 234 (8), 860-879, 2009 | 52 | 2009 |
| Splicing modulation sensitizes chronic lymphocytic leukemia cells to venetoclax by remodeling mitochondrial apoptotic dependencies E Ten Hacken, R Valentin, FFD Regis, J Sun, S Yin, L Werner, J Deng, ... JCI insight 3 (19), 2018 | 49 | 2018 |
Silvia BuonamiciConsultant Third Rock VenturesVerified email at thirdrockventures.com
