|CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms|
RV Parry, JM Chemnitz, KA Frauwirth, AR Lanfranco, I Braunstein, ...
Molecular and cellular biology 25 (21), 9543-9553, 2005
|Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases|
EE Perez, J Wang, JC Miller, Y Jouvenot, KA Kim, O Liu, N Wang, G Lee, ...
Nature biotechnology 26 (7), 808-816, 2008
|The CD28 signaling pathway regulates glucose metabolism|
KA Frauwirth, JL Riley, MH Harris, RV Parry, JC Rathmell, DR Plas, ...
Immunity 16 (6), 769-777, 2002
|SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T …|
JM Chemnitz, RV Parry, KE Nichols, CH June, JL Riley
The Journal of Immunology 173 (2), 945-954, 2004
|Cutting edge: regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation|
EY Woo, H Yeh, CS Chu, K Schlienger, RG Carroll, JL Riley, LR Kaiser, ...
The Journal of Immunology 168 (9), 4272-4276, 2002
|Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo|
MC Milone, JD Fish, C Carpenito, RG Carroll, GK Binder, D Teachey, ...
Molecular therapy 17 (8), 1453-1464, 2009
|Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains|
C Carpenito, MC Milone, R Hassan, JC Simonet, M Lakhal, MM Suhoski, ...
Proceedings of the National Academy of Sciences 106 (9), 3360-3365, 2009
|PD‐1 signaling in primary T cells|
Immunological reviews 229 (1), 114-125, 2009
|Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells|
J Scholler, TL Brady, G Binder-Scholl, WT Hwang, G Plesa, KM Hege, ...
Science translational medicine 4 (132), 132ra53-132ra53, 2012
|Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB|
MV Maus, AK Thomas, DGB Leonard, D Allman, K Addya, K Schlienger, ...
Nature biotechnology 20 (2), 143-148, 2002
|Human T regulatory cell therapy: take a billion or so and call me in the morning|
JL Riley, CH June, BR Blazar
Immunity 30 (5), 656-665, 2009
|Identification of a Titin-derived HLA-A1–presented peptide as a cross-reactive target for engineered MAGE A3–directed T cells|
BJ Cameron, AB Gerry, J Dukes, JV Harper, V Kannan, FC Bianchi, ...
Science translational medicine 5 (197), 197ra103-197ra103, 2013
|FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression|
B Li, A Samanta, X Song, KT Iacono, K Bembas, R Tao, S Basu, JL Riley, ...
Proceedings of the National Academy of Sciences 104 (11), 4571-4576, 2007
|The CD28 family: a T-cell rheostat for therapeutic control of T-cell activation|
JL Riley, CH June
Blood 105 (1), 13-21, 2005
|DC-SIGN and DC-SIGNR bind ebola glycoproteins and enhance infection of macrophages and endothelial cells|
G Simmons, JD Reeves, CC Grogan, LH Vandenberghe, F Baribaud, ...
Virology 305 (1), 115-123, 2003
|Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors|
JL Riley, M Mao, S Kobayashi, M Biery, J Burchard, G Cavet, BP Gregson, ...
Proceedings of the National Academy of Sciences 99 (18), 11790-11795, 2002
|The PDL1-PD1 axis converts human TH1 cells into regulatory T cells|
S Amarnath, CW Mangus, JCM Wang, F Wei, A He, V Kapoor, JE Foley, ...
Science translational medicine 3 (111), 111ra120-111ra120, 2011
|Expression of a functional CCR2 receptor enhances tumor localization and tumor eradication by retargeted human T cells expressing a mesothelin-specific chimeric antibody receptor|
EK Moon, C Carpenito, J Sun, LCS Wang, V Kapoor, J Predina, DJ Powell, ...
Clinical cancer research 17 (14), 4719-4730, 2011
|Massive ex vivo expansion of human natural regulatory T cells (Tregs) with minimal loss of in vivo functional activity|
KL Hippen, SC Merkel, DK Schirm, CM Sieben, D Sumstad, DM Kadidlo, ...
Science translational medicine 3 (83), 83ra41-83ra41, 2011
|Chronic virus infection enforces demethylation of the locus that encodes PD-1 in antigen-specific CD8+ T cells|
B Youngblood, KJ Oestreich, SJ Ha, J Duraiswamy, RS Akondy, EE West, ...
Immunity 35 (3), 400-412, 2011