| The kink‐turn: a new RNA secondary structure motif DJ Klein, TM Schmeing, PB Moore, TA Steitz The EMBO journal, 2001 | 904 | 2001 |
| The roles of ribosomal proteins in the structure assembly, and evolution of the large ribosomal subunit DJ Klein, PB Moore, TA Steitz Journal of molecular biology 340 (1), 141-177, 2004 | 530 | 2004 |
| Structural basis of glmS ribozyme activation by glucosamine-6-phosphate DJ Klein, AR Ferré-D'Amaré Science 313 (5794), 1752-1756, 2006 | 445 | 2006 |
| The contribution of metal ions to the structural stability of the large ribosomal subunit DJ Klein, PB Moore, TA Steitz Rna 10 (9), 1366-1379, 2004 | 361 | 2004 |
| SARS-CoV-2 tropism, entry, replication, and propagation: Considerations for drug discovery and development N Murgolo, AG Therien, B Howell, D Klein, K Koeplinger, LA Lieberman, ... Advances in Clinical Immunology, Medical Microbiology, COVID-19, and Big …, 2021 | 214 | 2021 |
| Cocrystal structure of a class I preQ1 riboswitch reveals a pseudoknot recognizing an essential hypermodified nucleobase DJ Klein, TE Edwards, AR Ferré-D'Amaré Nature structural & molecular biology 16 (3), 343-344, 2009 | 192 | 2009 |
| Riboswitches: small-molecule recognition by gene regulatory RNAs TE Edwards, DJ Klein, AR Ferré-D’Amaré Current opinion in structural biology 17 (3), 273-279, 2007 | 188 | 2007 |
| Discovery of MK-8719, a potent O-GlcNAcase inhibitor as a potential treatment for tauopathies HG Selnick, JF Hess, C Tang, K Liu, JB Schachter, JE Ballard, J Marcus, ... Journal of medicinal chemistry 62 (22), 10062-10097, 2019 | 113 | 2019 |
| Essential role of an active-site guanine in glmS ribozyme catalysis DJ Klein, MD Been, AR Ferré-D'Amaré Journal of the American Chemical Society 129 (48), 14858-14859, 2007 | 113 | 2007 |
| Requirement of helix P2. 2 and nucleotide G1 for positioning the cleavage site and cofactor of the glmS ribozyme DJ Klein, SR Wilkinson, MD Been, AR Ferré-D'Amaré Journal of molecular biology 373 (1), 178-189, 2007 | 94 | 2007 |
| Insights into activity and inhibition from the crystal structure of human O-GlcNAcase NL Elsen, SB Patel, RE Ford, DL Hall, F Hess, H Kandula, M Kornienko, ... Nature chemical biology 13 (6), 613-615, 2017 | 91 | 2017 |
| Discovery of selective RNA-binding small molecules by affinity-selection mass spectrometry NF Rizvi, JA Howe, A Nahvi, DJ Klein, TO Fischmann, HY Kim, MA McCoy, ... ACS chemical biology 13 (3), 820-831, 2018 | 88 | 2018 |
| Targeting RNA with small molecules: identification of selective, RNA-binding small molecules occupying drug-like chemical space NF Rizvi, JP Santa Maria Jr, A Nahvi, J Klappenbach, DJ Klein, PJ Curran, ... SLAS DISCOVERY: Advancing the Science of Drug Discovery 25 (4), 384-396, 2020 | 69 | 2020 |
| Structure of the bacterial deacetylase LpxC bound to the nucleotide reaction product reveals mechanisms of oxyanion stabilization and proton transfer GM Clayton, DJ Klein, KW Rickert, SB Patel, M Kornienko, ... Journal of Biological Chemistry 288 (47), 34073-34080, 2013 | 47 | 2013 |
| Structure of the bacterial deacetylase LpxC bound to the nucleotide reaction product reveals mechanisms of oxyanion stabilization and proton transfer GM Clayton, DJ Klein, KW Rickert, SB Patel, M Kornienko, ... Journal of Biological Chemistry 288 (47), 34073-34080, 2013 | 47 | 2013 |
| The NMR Structure of the Nucleocapsid Protein from the Mouse Mammary Tumor Virus Reveals Unusual Folding of the C-Terminal Zinc Knuckle, DJ Klein, PE Johnson, ES Zollars, RN De Guzman, MF Summers Biochemistry 39 (7), 1604-1612, 2000 | 46 | 2000 |
| Identification and in vivo evaluation of liver X receptor β-selective agonists for the potential treatment of Alzheimer’s disease SJ Stachel, C Zerbinatti, MT Rudd, M Cosden, S Suon, KK Nanda, ... Journal of medicinal chemistry 59 (7), 3489-3498, 2016 | 44 | 2016 |
| The glmS Ribozyme Tunes the Catalytically Critical pKa of Its Coenzyme Glucosamine-6-phosphate B Gong, DJ Klein, AR Ferré-D’Amaré, PR Carey Journal of the American Chemical Society 133 (36), 14188-14191, 2011 | 42 | 2011 |
| Discovery of 2-pyridinone aminals: a prodrug strategy to advance a second generation of HIV-1 integrase strand transfer inhibitors IT Raheem, AM Walji, D Klein, JM Sanders, DA Powell, P Abeywickrema, ... Journal of medicinal chemistry 58 (20), 8154-8165, 2015 | 36 | 2015 |
| Discovery of 2-pyridinone aminals: a prodrug strategy to advance a second generation of HIV-1 integrase strand transfer inhibitors IT Raheem, AM Walji, D Klein, JM Sanders, DA Powell, P Abeywickrema, ... Journal of medicinal chemistry 58 (20), 8154-8165, 2015 | 36 | 2015 |
