Andrea Carotti
Andrea Carotti
Perugia, Bari
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Structural insights into monoamine oxidase inhibitory potency and selectivity of 7-substituted coumarins from ligand-and target-based approaches
M Catto, O Nicolotti, F Leonetti, A Carotti, AD Favia, R Soto-Otero, ...
Journal of medicinal chemistry 49 (16), 4912-4925, 2006
Natural and synthetic geiparvarins are strong and selective MAO-B inhibitors. Synthesis and SAR studies
A Carotti, A Carrieri, S Chimichi, M Boccalini, B Cosimelli, C Gnerre, ...
Bioorganic & medicinal chemistry letters 12 (24), 3551-3555, 2002
Extending SAR of bile acids as FXR ligands: Discovery of 23-N-(carbocinnamyloxy)-3α,7α-dihydroxy-6α-ethyl-24-nor-5β-cholan-23-amine
A Gioiello, A Macchiarulo, A Carotti, P Filipponi, G Costantino, G Rizzo, ...
Bioorganic & medicinal chemistry 19 (8), 2650-2658, 2011
Fluorinated benzyloxyphenyl piperidine-4-carboxamides with dual function against thrombosis: inhibitors of factor Xa and platelet aggregation
M de Candia, F Liantonio, A Carotti, R De Cristofaro, C Altomare
Journal of medicinal chemistry 52 (4), 1018-1028, 2009
Binding models of reversible inhibitors to type-B monoamine oxidase
A Carrieri, A Carotti, ML Barreca, C Altomare
Journal of computer-aided molecular design 16 (11), 769-778, 2002
An integrated approach to ligand-and structure-based drug design: development and application to a series of serine protease inhibitors
O Nicolotti, TF Miscioscia, A Carotti, F Leonetti, A Carotti
Journal of chemical information and modeling 48 (6), 1211-1226, 2008
Synthesis and monoamine oxidase inhibitory activity of new pyridazine-, pyrimidine-and 1, 2, 4-triazine-containing tricyclic derivatives
A Carotti, M Catto, F Leonetti, F Campagna, R Soto-Otero, ...
Journal of medicinal chemistry 50 (22), 5364-5371, 2007
From polypharmacology to target specificity: the case of PARP inhibitors
P Liscio, E Camaioni, A Carotti, R Pellicciari, A Macchiarulo
Current topics in medicinal chemistry 13 (23), 2939-2954, 2013
Pyrazole [3, 4-e][1, 4] thiazepin-7-one derivatives as a novel class of farnesoid X receptor (FXR) agonists
M Marinozzi, A Carotti, E Sansone, A Macchiarulo, E Rosatelli, R Sardella, ...
Bioorganic & medicinal chemistry 20 (11), 3429-3445, 2012
Targeting Wnt-driven cancers: Discovery of novel tankyrase inhibitors
M Ferri, P Liscio, A Carotti, S Asciutti, R Sardella, A Macchiarulo, ...
European journal of medicinal chemistry 142, 506-522, 2017
Discovery of 3α, 7α, 11β-trihydroxy-6α-ethyl-5β-cholan-24-oic acid (TC-100), a novel bile acid as potent and highly selective FXR agonist for enterohepatic disorders
R Pellicciari, D Passeri, F De Franco, S Mostarda, P Filipponi, C Colliva, ...
Journal of medicinal chemistry 59 (19), 9201-9214, 2016
Beyond bile acids: targeting Farnesoid X Receptor (FXR) with natural and synthetic ligands
A Carotti, M Marinozzi, C Custodi, B Cerra, R Pellicciari, A Gioiello, ...
Current topics in medicinal chemistry 14 (19), 2129-2142, 2014
Ester derivatives of annulated tetrahydroazocines: A new class of selective acetylcholinesterase inhibitors
A Carotti, M de Candia, M Catto, TN Borisova, AV Varlamov, ...
Bioorganic & medicinal chemistry 14 (21), 7205-7212, 2006
A natural prothrombin mutant reveals an unexpected influence of a-chain structure on the activity of human α-thrombin
R De Cristofaro, S Akhavan, C Altomare, A Carotti, F Peyvandi, ...
Journal of Biological Chemistry 279 (13), 13035-13043, 2004
The natural mutation by deletion of Lys9 in the thrombin A‐chain affects the pKa value of catalytic residues, the overall enzyme's stability and conformational transitions …
R De Cristofaro, A Carotti, S Akhavan, R Palla, F Peyvandi, C Altomare, ...
The FEBS journal 273 (1), 159-169, 2006
High affinity central benzodiazepine receptor ligands. Part 3: insights into the pharmacophore and pattern recognition study of intrinsic activities of pyrazolo [4, 3-c …
A Carotti, C Altomare, L Savini, L Chiasserini, C Pellerano, MP Mascia, ...
Bioorganic & medicinal chemistry 11 (23), 5259-5272, 2003
Mechanistic considerations of enantiorecognition on novel Cinchona alkaloid-based zwitterionic chiral stationary phases from the aspect of the separation of trans-paroxetine …
N Grecsó, M Kohout, A Carotti, R Sardella, B Natalini, F Fülöp, W Lindner, ...
Journal of pharmaceutical and biomedical analysis 124, 164-173, 2016
Targeting the conformational transitions of MDM2 and MDMX: insights into dissimilarities and similarities of p53 recognition
A Macchiarulo, N Giacche, A Carotti, M Baroni, G Cruciani, R Pellicciari
Journal of chemical information and modeling 48 (10), 1999-2009, 2008
4, 5-Diarylisoxazol-3-carboxylic acids: A new class of leukotriene biosynthesis inhibitors potentially targeting 5-lipoxygenase-activating protein (FLAP)
E Banoglu, E Çelikoğlu, S Voelker, A Olgac, J Gerstmeier, U Garscha, ...
European journal of medicinal chemistry 113, 1-10, 2016
Design, Synthesis, Crystallographic Studies, and Preliminary Biological Appraisal of New Substituted Triazolo[4,3-b]pyridazin-8-amine Derivatives as Tankyrase …
P Liscio, A Carotti, S Asciutti, T Karlberg, D Bellocchi, L Llacuna, ...
Journal of medicinal chemistry 57 (6), 2807-2812, 2014
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