Joshua J. Ziarek
Joshua J. Ziarek
Associate Professor of Pharmacology, Northwestern University
Verified email at - Homepage
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Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways
LJ Drury, JJ Ziarek, S Gravel, CT Veldkamp, T Takekoshi, ST Hwang, ...
Proceedings of the National Academy of Sciences 108 (43), 17655-17660, 2011
Structure-based ligand discovery for the protein–protein interface of chemokine receptor CXCR4
MM Mysinger, DR Weiss, JJ Ziarek, S Gravel, AK Doak, J Karpiak, ...
Proceedings of the National Academy of Sciences 109 (14), 5517-5522, 2012
New paradigms in chemokine receptor signal transduction: Moving beyond the two-site model
AB Kleist, AE Getschman, JJ Ziarek, AM Nevins, PA Gauthier, A Chevigné, ...
Biochemical pharmacology 114, 53-68, 2016
Monomeric structure of the cardioprotective chemokine SDF‐1/CXCL12
CT Veldkamp, JJ Ziarek, J Su, H Basnet, R Lennertz, JJ Weiner, ...
Protein Science 18 (7), 1359-1369, 2009
The CXC chemokine receptor 4 ligands ubiquitin and stromal cell-derived factor-1α function through distinct receptor interactions
V Saini, DM Staren, JJ Ziarek, ZN Nashaat, EM Campbell, BF Volkman, ...
Journal of Biological Chemistry 286 (38), 33466-33477, 2011
Binding site identification and structure determination of protein–ligand complexes by NMR: a semiautomated approach
JJ Ziarek, FC Peterson, BL Lytle, BF Volkman
Methods in enzymology 493, 241-275, 2011
Heparin oligosaccharides inhibit chemokine (CXC motif) ligand 12 (CXCL12) cardioprotection by binding orthogonal to the dimerization interface, promoting oligomerization, and …
JJ Ziarek, CT Veldkamp, F Zhang, NJ Murray, GA Kartz, X Liang, J Su, ...
Journal of Biological Chemistry 288 (1), 737-746, 2013
Structural basis for chemokine recognition by a G protein–coupled receptor and implications for receptor activation
JJ Ziarek, AB Kleist, N London, B Raveh, N Montpas, J Bonneterre, ...
Science signaling 10 (471), eaah5756, 2017
A locked, dimeric CXCL12 variant effectively inhibits pulmonary metastasis of CXCR4-expressing melanoma cells due to enhanced serum stability
T Takekoshi, JJ Ziarek, BF Volkman, ST Hwang
Molecular cancer therapeutics 11 (11), 2516-2525, 2012
Targeting SDF-1/CXCL12 with a ligand that prevents activation of CXCR4 through structure-based drug design
CT Veldkamp, JJ Ziarek, FC Peterson, Y Chen, BF Volkman
Journal of the American Chemical Society 132 (21), 7242-7243, 2010
Sulfopeptide probes of the CXCR4/CXCL12 interface reveal oligomer-specific contacts and chemokine allostery
JJ Ziarek, AE Getschman, SJ Butler, D Taleski, B Stephens, I Kufareva, ...
ACS chemical biology 8 (9), 1955-1963, 2013
Solution structure of CCL21 and identification of a putative CCR7 binding site
M Love, JL Sandberg, JJ Ziarek, KP Gerarden, RR Rode, DR Jensen, ...
Biochemistry 51 (3), 733-735, 2012
15N detection harnesses the slow relaxation property of nitrogen: Delivering enhanced resolution for intrinsically disordered proteins
S Chhabra, P Fischer, K Takeuchi, A Dubey, JJ Ziarek, A Boeszoermenyi, ...
Proceedings of the National Academy of Sciences 115 (8), E1710-E1719, 2018
Discovery and Characterization of a Disulfide-Locked C2-Symmetric Defensin Peptide
AJ Wommack, JJ Ziarek, J Tomaras, HR Chileveru, Y Zhang, G Wagner, ...
Journal of the American Chemical Society 136 (39), 13494-13497, 2014
Biased antagonism of CXCR4 avoids antagonist tolerance
B Hitchinson, JM Eby, X Gao, F Guite-Vinet, JJ Ziarek, H Abdelkarim, ...
Science signaling 11 (552), eaat2214, 2018
Chemokine cooperativity is caused by competitive glycosaminoglycan binding
F Verkaar, J Van Offenbeek, M van der Lee, LHCJ Van Lith, AO Watts, ...
The Journal of Immunology 192 (8), 3908-3914, 2014
Fragment-based optimization of small molecule CXCL12 inhibitors for antagonizing the CXCL12/CXCR4 interaction
J J Ziarek, Y Liu, E Smith, G Zhang, F C Peterson, J Chen, Y Yu, Y Chen, ...
Current topics in medicinal chemistry 12 (24), 2727-2740, 2012
Seasonal adaptations of Daphnia pulicaria swimming behaviour: the effect of water temperature
JJ Ziarek, A Nihongi, T Nagai, M Uttieri, JR Strickler
Hydrobiologia 661, 317-327, 2011
Recent developments in solution nuclear magnetic resonance (NMR)-based molecular biology
JJ Ziarek, D Baptista, G Wagner
Journal of Molecular Medicine 96, 1-8, 2018
Structural analysis of a novel small molecule ligand bound to the CXCL12 chemokine
EW Smith, Y Liu, AE Getschman, FC Peterson, JJ Ziarek, R Li, ...
Journal of medicinal chemistry 57 (22), 9693-9699, 2014
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