| Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques JH Lee, DS Yang, CN Goulbourne, E Im, P Stavrides, A Pensalfini, ... Nature neuroscience 25 (6), 688-701, 2022 | 394 | 2022 |
| Lysosomal dysfunction in Down syndrome is APP-dependent and mediated by APP-βCTF (C99) Y Jiang, Y Sato, E Im, M Berg, M Bordi, S Darji, A Kumar, PS Mohan, ... Journal of Neuroscience 39 (27), 5255-5268, 2019 | 127 | 2019 |
| Parkin directly modulates 26S proteasome activity JW Um, E Im, HJ Lee, B Min, L Yoo, J Yoo, H Lübbert, C Stichel-Gunkel, ... Journal of Neuroscience 30 (35), 11805-11814, 2010 | 104 | 2010 |
| Transgenic expression of a ratiometric autophagy probe specifically in neurons enables the interrogation of brain autophagy in vivo JH Lee, MV Rao, DS Yang, P Stavrides, E Im, A Pensalfini, C Huo, ... Autophagy 15 (3), 543-557, 2019 | 63 | 2019 |
| Neddylation positively regulates the ubiquitin E3 ligase activity of parkin JW Um, KA Han, E Im, Y Oh, K Lee, KC Chung Journal of neuroscience research 90 (5), 1030-1042, 2012 | 60 | 2012 |
| ASK1 Negatively Regulates the 26 S Proteasome*♦ JW Um, E Im, J Park, Y Oh, B Min, HJ Lee, JB Yoon, KC Chung Journal of Biological Chemistry 285 (47), 36434-36446, 2010 | 53 | 2010 |
| Covalent ISG15 conjugation positively regulates the ubiquitin E3 ligase activity of parkin E Im, L Yoo, M Hyun, WH Shin, KC Chung Open biology 6 (8), 160193, 2016 | 45 | 2016 |
| The three-dimensional landscape of cortical chromatin accessibility in Alzheimer’s disease J Bendl, ME Hauberg, K Girdhar, E Im, JM Vicari, S Rahman, ... Nature neuroscience 25 (10), 1366-1378, 2022 | 42 | 2022 |
| Dyrk1A phosphorylates parkin at Ser‐131 and negatively regulates its ubiquitin E3 ligase activity E Im, KC Chung Journal of neurochemistry 134 (4), 756-768, 2015 | 32 | 2015 |
| Human telomerase reverse transcriptase (hTERT) positively regulates 26S proteasome activity E Im, JB Yoon, HW Lee, KC Chung Journal of Cellular Physiology 232 (8), 2083-2093, 2017 | 31 | 2017 |
| Precise assembly and regulation of 26S proteasome and correlation between proteasome dysfunction and neurodegenerative diseases E Im, KC Chung BMB reports 49 (9), 459, 2016 | 28 | 2016 |
| Lysosomal dysfunction in Down syndrome and Alzheimer mouse models is caused by v-ATPase inhibition by Tyr682-phosphorylated APP βCTF E Im, Y Jiang, PH Stavrides, S Darji, H Erdjument-Bromage, TA Neubert, ... Science Advances 9 (30), eadg1925, 2023 | 27 | 2023 |
| Covalent NEDD8 conjugation increases RCAN1 protein stability and potentiates its inhibitory action on calcineurin EH Noh, HS Hwang, HS Hwang, B Min, E Im, KC Chung PloS one 7 (10), e48315, 2012 | 23 | 2012 |
| Protein phosphatase PPM1B inhibits DYRK1A kinase through dephosphorylation of pS258 and reduces toxic tau aggregation YH Lee, E Im, M Hyun, J Park, KC Chung Journal of Biological Chemistry 296, 2021 | 15 | 2021 |
| Histone deacetylase 3 promotes RCAN1 stability and nuclear translocation KA Han, HS Kang, JW Lee, L Yoo, E Im, A Hong, YJ Lee, WH Shin, ... PloS one 9 (8), e105416, 2014 | 14 | 2014 |
| Lysosomal dysfunction in Down Syndrome and Alzheimer mouse models is caused by selective v-ATPase inhibition by Tyr682 phosphorylated APP βCTF E Im, Y Jiang, P Stavrides, S Darji, H Erdjument-Bromage, TA Neubert, ... bioRxiv, 2022.06. 02.494546, 2022 | 8 | 2022 |
| Pharmacological reacidification of lysosomes attenuates intraneuronal amyloidosis, early neuron death, and amyloid plaque formation in 5xFAD mice S Malampati, P Stavrides, E Im, CN Goulbourne, PS Mohan, BC Das, ... Alzheimer's Association International Conference, 2024 | 1 | 2024 |
| Transgenic expression of a ratiometric autophagy probe specifically in neurons enables the interrogation of brain autophagy in vivo L Ju-Hyun, MV Rao, DS Yang, P Stavrides, E Im, A Pensalfini, C Huo, ... Autophagy, 2018 | 1 | 2018 |
| The three-dimensional landscape of chromatin accessibility in Alzheimer’s disease J Bendl, ME Hauberg, K Girdhar, E Im, JM Vicari, S Rahman, P Dong, ... BioRxiv, 2021.01. 11.426303, 2021 | | 2021 |
