|Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques|
JH Lee, DS Yang, CN Goulbourne, E Im, P Stavrides, A Pensalfini, ...
Nature neuroscience 25 (6), 688-701, 2022
|Lysosomal dysfunction in Down syndrome is APP-dependent and mediated by APP-βCTF (C99)|
Y Jiang, Y Sato, E Im, M Berg, M Bordi, S Darji, A Kumar, PS Mohan, ...
Journal of Neuroscience 39 (27), 5255-5268, 2019
|Parkin directly modulates 26S proteasome activity|
JW Um, E Im, HJ Lee, B Min, L Yoo, J Yoo, H Lübbert, C Stichel-Gunkel, ...
Journal of Neuroscience 30 (35), 11805-11814, 2010
|Neddylation positively regulates the ubiquitin E3 ligase activity of parkin|
JW Um, KA Han, E Im, Y Oh, K Lee, KC Chung
Journal of neuroscience research 90 (5), 1030-1042, 2012
|Transgenic expression of a ratiometric autophagy probe specifically in neurons enables the interrogation of brain autophagy in vivo|
JH Lee, MV Rao, DS Yang, P Stavrides, E Im, A Pensalfini, C Huo, ...
Autophagy 15 (3), 543-557, 2019
|ASK1 Negatively Regulates the 26 S Proteasome*♦|
JW Um, E Im, J Park, Y Oh, B Min, HJ Lee, JB Yoon, KC Chung
Journal of Biological Chemistry 285 (47), 36434-36446, 2010
|Covalent ISG15 conjugation positively regulates the ubiquitin E3 ligase activity of parkin|
E Im, L Yoo, M Hyun, WH Shin, KC Chung
Open biology 6 (8), 160193, 2016
|Dyrk1A phosphorylates parkin at Ser‐131 and negatively regulates its ubiquitin E3 ligase activity|
E Im, KC Chung
Journal of neurochemistry 134 (4), 756-768, 2015
|Human telomerase reverse transcriptase (hTERT) positively regulates 26S proteasome activity|
E Im, JB Yoon, HW Lee, KC Chung
Journal of Cellular Physiology 232 (8), 2083-2093, 2017
|The three-dimensional landscape of cortical chromatin accessibility in Alzheimer’s disease|
J Bendl, ME Hauberg, K Girdhar, E Im, JM Vicari, S Rahman, ...
Nature Neuroscience 25 (10), 1366-1378, 2022
|Precise assembly and regulation of 26S proteasome and correlation between proteasome dysfunction and neurodegenerative diseases|
E Im, KC Chung
BMB reports 49 (9), 459, 2016
|Covalent NEDD8 conjugation increases RCAN1 protein stability and potentiates its inhibitory action on calcineurin|
EH Noh, HS Hwang, HS Hwang, B Min, E Im, KC Chung
PloS one 7 (10), e48315, 2012
|Protein phosphatase PPM1B inhibits DYRK1A kinase through dephosphorylation of pS258 and reduces toxic tau aggregation|
YH Lee, E Im, M Hyun, J Park, KC Chung
Journal of Biological Chemistry 296, 2021
|Histone deacetylase 3 promotes RCAN1 stability and nuclear translocation|
KA Han, HS Kang, JW Lee, L Yoo, E Im, A Hong, YJ Lee, WH Shin, ...
PloS one 9 (8), e105416, 2014
|Lysosomal dysfunction in Down Syndrome and Alzheimer mouse models is caused by selective v-ATPase inhibition by Tyr682 phosphorylated APP βCTF|
E Im, Y Jiang, P Stavrides, S Darji, H Erdjument-Bromage, TA Neubert, ...
bioRxiv, 2022.06. 02.494546, 2022
|Lysosomal dysfunction in Down syndrome and Alzheimer mouse models is caused by v-ATPase inhibition by Tyr682-phosphorylated APP βCTF|
E Im, Y Jiang, PH Stavrides, S Darji, H Erdjument-Bromage, TA Neubert, ...
Science Advances 9 (30), eadg1925, 2023
|The three-dimensional landscape of chromatin accessibility in Alzheimer’s disease|
J Bendl, ME Hauberg, K Girdhar, E Im, JM Vicari, S Rahman, P Dong, ...
BioRxiv, 2021.01. 11.426303, 2021