| De novo NAD+ synthesis enhances mitochondrial function and improves health E Katsyuba, A Mottis, M Zietak, F De Franco, V van der Velpen, K Gariani, ... Nature 563 (7731), 354-359, 2018 | 357 | 2018 |
| Development of 1, 2, 4-oxadiazoles as potent and selective inhibitors of the human deacetylase sirtuin 2: structure–activity relationship, X-ray crystal structure, and … S Moniot, M Forgione, A Lucidi, GS Hailu, A Nebbioso, V Carafa, F Baratta, ... Journal of medicinal chemistry 60 (6), 2344-2360, 2017 | 92 | 2017 |
| Targeting the MDM2/MDM4 interaction interface as a promising approach for p53 reactivation therapy M Pellegrino, F Mancini, R Lucà, A Coletti, N Giacchè, I Manni, I Arisi, ... Cancer research 75 (21), 4560-4572, 2015 | 55 | 2015 |
| Probing the binding site of bile acids in TGR5 A Macchiarulo, A Gioiello, C Thomas, TWH Pols, R Nuti, C Ferrari, ... ACS medicinal chemistry letters 4 (12), 1158-1162, 2013 | 55 | 2013 |
| Indoleamine 2, 3-dioxygenase 1 activation in mature cDC1 promotes tolerogenic education of inflammatory cDC2 via metabolic communication M Gargaro, G Scalisi, G Manni, CG Briseño, P Bagadia, V Durai, ... Immunity 55 (6), 1032-1050. e14, 2022 | 46 | 2022 |
| Bulky 1, 4-benzoxazine derivatives with antifungal activity R Fringuelli, N Giacchè, L Milanese, E Cenci, A Macchiarulo, ... Bioorganic & medicinal chemistry 17 (11), 3838-3846, 2009 | 44 | 2009 |
| α-Amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) inhibitors as novel modulators of de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis R Pellicciari, P Liscio, N Giacchè, F De Franco, A Carotti, J Robertson, ... Journal of medicinal chemistry 61 (3), 745-759, 2018 | 41 | 2018 |
| Targeting the conformational transitions of MDM2 and MDMX: insights into dissimilarities and similarities of p53 recognition A Macchiarulo, N Giacche, A Carotti, M Baroni, G Cruciani, R Pellicciari Journal of chemical information and modeling 48 (10), 1999-2009, 2008 | 36 | 2008 |
| Concepts and Molecular Aspects in the Polypharmacology of PARP‐1 Inhibitors D Passeri, E Camaioni, P Liscio, P Sabbatini, M Ferri, A Carotti, ... ChemMedChem 11 (12), 1219-1226, 2016 | 33 | 2016 |
| Design, synthesis and biological evaluation of novel bicyclo [1.1. 1] pentane-based ω-acidic amino acids as glutamate receptors ligands R Filosa, MC Fulco, M Marinozzi, N Giacchè, A Macchiarulo, A Peduto, ... Bioorganic & medicinal chemistry 17 (1), 242-250, 2009 | 31 | 2009 |
| Expanding the horizon of chemotherapeutic targets: From MDM2 to MDMX (MDM4) A Macchiarulo, N Giacchè, A Carotti, F Moretti, R Pellicciari MedChemComm 2 (6), 455-465, 2011 | 21 | 2011 |
| Computational studies for the elucidation of the enantiomer elution order of amino acids in chiral ligand-exchange chromatography B Natalini, N Giacchè, R Sardella, F Ianni, A Macchiarulo, R Pellicciari Journal of Chromatography A 1217 (48), 7523-7527, 2010 | 21 | 2010 |
| Oxime and Oxime Ether Derivatives of 1, 4‐Benzothiazine Related to Oxiconazole L Milanese, N Giacchè, F Schiaffella, A Vecchiarelli, A Macchiarulo, ... ChemMedChem: Chemistry Enabling Drug Discovery 2 (8), 1208-1213, 2007 | 20 | 2007 |
| Probing fluorinated motifs onto dual AChE-MAO B inhibitors: Rational design, synthesis, biological evaluation, and early-ADME studies M Rullo, M Cipolloni, M Catto, C Colliva, DV Miniero, T Latronico, ... Journal of Medicinal Chemistry 65 (5), 3962-3977, 2022 | 18 | 2022 |
| Chiral ligand-exchange separation and resolution of extremely rigid glutamate analogs: 1-aminospiro [2.2] pentyl-1, 4-dicarboxylic acids B Natalini, R Sardella, N Giacchè, S Palmiotto, E Camaioni, M Marinozzi, ... Analytical and bioanalytical chemistry 397, 1997-2011, 2010 | 12 | 2010 |
| Targeting the conformational transitions of MDM2 and MDMX: Insights into key residues affecting p53 recognition A Carotti, A Macchiarulo, N Giacche, R Pellicciari Proteins: Structure, Function, and Bioinformatics 77 (3), 524-535, 2009 | 12 | 2009 |
| Alternative strategies for targeting mouse double minute 2 activity with small molecules: novel patents on the horizon? A Macchiarulo, N Giacchè, F Mancini, E Puxeddu, F Moretti, R Pellicciari Expert opinion on therapeutic patents 21 (3), 287-294, 2011 | 11 | 2011 |
| Innovations and Emerging Therapies to Combat Renal Cell Damage: NAD+ As a Drug Target CL Manrique-Caballero, JA Kellum, H Gómez, F De Franco, N Giacche, ... Antioxidants & Redox Signaling 35 (17), 1449-1466, 2021 | 7 | 2021 |
| Structural basis of human dimeric α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase inhibition with TES-1025 M Cianci, N Giacchè, L Cialabrini, A Carotti, P Liscio, E Rosatelli, ... Frontiers in Molecular Biosciences 9, 834700, 2022 | 3 | 2022 |
| Use of an o-Benzyl-(S)-Serine Containing Eluent for the Efficient Ligand-Exchange Chromatography-Based Enantioseparation of Constrained Glutamate Receptor … F Ianni, R Sardella, A Lisanti, N Giacchè, P Conti, A Pinto, L Tamborini, ... Analytical Letters 48 (3), 383-395, 2015 | 3 | 2015 |
