Shen-Ying Zhang
Shen-Ying Zhang
Assistant Professor of Clinical Investigation, The Rockefeller University
Verified email at
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Autoantibodies against type I IFNs in patients with life-threatening COVID-19
P Bastard, LB Rosen, Q Zhang, E Michailidis, HH Hoffmann, Y Zhang, ...
Science 370 (6515), eabd4585, 2020
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
Q Zhang, P Bastard, Z Liu, J Le Pen, M Moncada-Velez, J Chen, M Ogishi, ...
Science 370 (6515), eabd4570, 2020
Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors
J Cros, N Cagnard, K Woollard, N Patey, SY Zhang, B Senechal, A Puel, ...
Immunity 33 (3), 375-386, 2010
Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors
J Cros, N Cagnard, K Woollard, N Patey, SY Zhang, B Senechal, A Puel, ...
Immunity 33 (3), 375-386, 2010
TLR3 deficiency in patients with herpes simplex encephalitis
SY Zhang, E Jouanguy, S Ugolini, A Smahi, G Elain, P Romero, D Segal, ...
science 317 (5844), 1522-1527, 2007
Herpes simplex virus encephalitis in human UNC-93B deficiency
A Casrouge, SY Zhang, C Eidenschenk, E Jouanguy, A Puel, K Yang, ...
Science 314 (5797), 308-312, 2006
Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation
X Zhang, D Bogunovic, B Payelle-Brogard, V Francois-Newton, SD Speer, ...
Nature 517 (7532), 89-93, 2015
Selective predisposition to bacterial infections in IRAK-4–deficient children: IRAK-4–dependent TLRs are otherwise redundant in protective immunity
CL Ku, H Von Bernuth, C Picard, SY Zhang, HH Chang, K Yang, ...
The Journal of experimental medicine 204 (10), 2407-2422, 2007
Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency
MJ Ciancanelli, SXL Huang, P Luthra, H Garner, Y Itan, S Volpi, ...
Science 348 (6233), 448-453, 2015
Autoantibodies neutralizing type I IFNs are present in~ 4% of uninfected individuals over 70 years old and account for~ 20% of COVID-19 deaths
P Bastard, A Gervais, T Le Voyer, J Rosain, Q Philippot, J Manry, ...
Science immunology 6 (62), eabl4340, 2021
Inborn errors of interferon (IFN)‐mediated immunity in humans: insights into the respective roles of IFN‐α/β, IFN‐γ, and IFN‐λ in host defense
SY Zhang, S Boisson‐Dupuis, A Chapgier, K Yang, J Bustamante, A Puel, ...
Immunological reviews 226 (1), 29-40, 2008
Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis
RP de Diego, V Sancho-Shimizu, L Lorenzo, A Puel, S Plancoulaine, ...
Immunity 33 (3), 400-411, 2010
Human TLR-7-,-8-, and-9-mediated induction of IFN-α/β and-λ is IRAK-4 dependent and redundant for protective immunity to viruses
K Yang, A Puel, S Zhang, C Eidenschenk, CL Ku, A Casrouge, C Picard, ...
Immunity 23 (5), 465-478, 2005
Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells
FG Lafaille, IM Pessach, SY Zhang, MJ Ciancanelli, M Herman, ...
Nature 491 (7426), 769-773, 2012
Characterization of Greater Middle Eastern genetic variation for enhanced disease gene discovery
EM Scott, A Halees, Y Itan, EG Spencer, Y He, MA Azab, SB Gabriel, ...
Nature genetics 48 (9), 1071-1076, 2016
Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency
V Sancho-Shimizu, RP De Diego, L Lorenzo, R Halwani, A Alangari, ...
The Journal of clinical investigation 121 (12), 4889-4902, 2011
X-linked recessive TLR7 deficiency in~ 1% of men under 60 years old with life-threatening COVID-19
T Asano, B Boisson, F Onodi, D Matuozzo, M Moncada-Velez, ...
Science immunology 6 (62), eabl4348, 2021
Herpes simplex virus encephalitis in a patient with complete TLR3 deficiency: TLR3 is otherwise redundant in protective immunity
Y Guo, M Audry, M Ciancanelli, L Alsina, J Azevedo, M Herman, ...
Journal of Experimental Medicine 208 (10), 2083-2098, 2011
The mutation significance cutoff: gene-level thresholds for variant predictions
Y Itan, L Shang, B Boisson, MJ Ciancanelli, JG Markle, ...
Nature methods 13 (2), 109-110, 2016
Heterozygous TBK1 mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood
M Herman, M Ciancanelli, YH Ou, L Lorenzo, M Klaudel-Dreszler, ...
Journal of Experimental Medicine 209 (9), 1567-1582, 2012
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