| Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles A Subramanian, P Tamayo, VK Mootha, S Mukherjee, BL Ebert, ... Proceedings of the National Academy of Sciences 102 (43), 15545-15550, 2005 | 42127 | 2005 |
| PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes VK Mootha, CM Lindgren, KF Eriksson, A Subramanian, S Sihag, J Lehar, ... Nature genetics 34 (3), 267-273, 2003 | 9503 | 2003 |
| Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1 Z Wu, P Puigserver, U Andersson, C Zhang, G Adelmant, V Mootha, ... Cell 98 (1), 115-124, 1999 | 4624 | 1999 |
| Metabolite profiles and the risk of developing diabetes TJ Wang, MG Larson, RS Vasan, S Cheng, EP Rhee, E McCabe, ... Nature medicine 17 (4), 448-453, 2011 | 3069 | 2011 |
| Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals X Xie, J Lu, EJ Kulbokas, TR Golub, V Mootha, K Lindblad-Toh, ... Nature 434 (7031), 338-345, 2005 | 2357 | 2005 |
| A mitochondrial protein compendium elucidates complex I disease biology DJ Pagliarini, SE Calvo, B Chang, SA Sheth, SB Vafai, SE Ong, ... Cell 134 (1), 112-123, 2008 | 2169 | 2008 |
| Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter JM Baughman, F Perocchi, HS Girgis, M Plovanich, CA Belcher-Timme, ... Nature 476 (7360), 341-345, 2011 | 1903 | 2011 |
| tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c MC Wei, T Lindsten, VK Mootha, S Weiler, A Gross, M Ashiya, ... Genes & development 14 (16), 2060-2071, 2000 | 1645 | 2000 |
| mTOR controls mitochondrial oxidative function through a YY1–PGC-1α transcriptional complex JT Cunningham, JT Rodgers, DH Arlow, F Vazquez, VK Mootha, ... nature 450 (7170), 736-740, 2007 | 1583 | 2007 |
| Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1α null mice J Lin, PH Wu, PT Tarr, KS Lindenberg, J St-Pierre, C Zhang, VK Mootha, ... Cell 119 (1), 121-135, 2004 | 1398 | 2004 |
| Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation M Jain, R Nilsson, S Sharma, N Madhusudhan, T Kitami, AL Souza, ... Science 336 (6084), 1040-1044, 2012 | 1397 | 2012 |
| MitoCarta2. 0: an updated inventory of mammalian mitochondrial proteins SE Calvo, KR Clauser, VK Mootha Nucleic acids research 44 (D1), D1251-D1257, 2016 | 1302 | 2016 |
| Proteomic mapping of mitochondria in living cells via spatially restricted enzymatic tagging HW Rhee, P Zou, ND Udeshi, JD Martell, VK Mootha, SA Carr, AY Ting Science 339 (6125), 1328-1331, 2013 | 1173 | 2013 |
| Directed evolution of APEX2 for electron microscopy and proximity labeling SS Lam, JD Martell, KJ Kamer, TJ Deerinck, MH Ellisman, VK Mootha, ... Nature methods 12 (1), 51-54, 2015 | 1138 | 2015 |
| Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria VK Mootha, J Bunkenborg, JV Olsen, M Hjerrild, JR Wisniewski, E Stahl, ... Cell 115 (5), 629-640, 2003 | 1070 | 2003 |
| Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARγ coactivator-1 P Puigserver, J Rhee, J Lin, Z Wu, JC Yoon, CY Zhang, S Krauss, ... Molecular cell 8 (5), 971-982, 2001 | 927 | 2001 |
| Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans SE Calvo, DJ Pagliarini, VK Mootha Proceedings of the National Academy of Sciences 106 (18), 7507-7512, 2009 | 922 | 2009 |
| MICU1 encodes a mitochondrial EF hand protein required for Ca2+ uptake F Perocchi, VM Gohil, HS Girgis, XR Bao, JE McCombs, AE Palmer, ... Nature 467 (7313), 291-296, 2010 | 915 | 2010 |
| Errα and Gabpa/b specify PGC-1α-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle VK Mootha, C Handschin, D Arlow, X Xie, J St. Pierre, S Sihag, W Yang, ... Proceedings of the National Academy of Sciences 101 (17), 6570-6575, 2004 | 817 | 2004 |
| Energy metabolism in uncoupling protein 3 gene knockout mice AJ Vidal-Puig, D Grujic, CY Zhang, T Hagen, O Boss, Y Ido, A Szczepanik, ... Journal of Biological Chemistry 275 (21), 16258-16266, 2000 | 804 | 2000 |
Sarah E CalvoBroad Institute, Massachusetts General Hospital, Harvard Medical SchoolVerified email at broadinstitute.org
