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Patrick Ernst
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Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation
MP Tariq Afroz, Eva-Maria Hock, Patrick Ernst, Chiara Foglieni, Melanie ...
Nature Communications 8, 2017
2682017
Reprogramming Bacteriophage Host Range through Structure-Guided Design of Chimeric Receptor Binding Proteins
M Dunne, B Rupf, M Tala, X Qabrati, P Ernst, Y Shen, E Sumrall, L Heeb, ...
Cell reports 29 (5), 1336-1350. e4, 2019
1512019
Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control
M Schmid, P Ernst, A Honegger, M Suomalainen, M Zimmermann, ...
Nature communications 9 (1), 450, 2018
772018
Design and applications of a clamp for Green Fluorescent Protein with picomolar affinity
S Hansen, JC Stüber, P Ernst, A Koch, D Bojar, A Batyuk, A Plückthun
Scientific reports 7 (1), 16292, 2017
552017
Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action
F Kast, M Schwill, JC Stüber, S Pfundstein, G Nagy-Davidescu, ...
Nature Communications 12 (1), 3790, 2021
312021
Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism
M Deluigi, A Klipp, C Klenk, L Merklinger, SA Eberle, L Morstein, P Heine, ...
Science Advances 7 (5), eabe5504, 2021
312021
Chaperone-assisted structure elucidation with DARPins
PRE Mittl, P Ernst, A Plückthun
Current Opinion in Structural Biology 60, 93-100, 2020
252020
Computationally Designed Armadillo Repeat Proteins for Modular Peptide Recognition
C Reichen, S Hansen, C Forzani, A Honegger, SJ Fleishman, T Zhou, ...
Journal of Molecular Biology 428 (22), 4467-4489, 2016
222016
Structural analysis of biological targets by host: guest crystal lattice engineering
P Ernst, A Plückthun, PRE Mittl
Scientific reports 9 (1), 1-11, 2019
202019
Advances in the design and engineering of peptide-binding repeat proteins
P Ernst, A Plückthun
Biological chemistry 398 (1), 23-29, 2017
182017
An Interface-Driven Design Strategy Yields a Novel, Corrugated Protein Architecture
M ElGamacy, M Coles, P Ernst, H Zhu, MD Hartmann, A Plückthun, ...
ACS synthetic biology 7 (9), 2226-2235, 2018
142018
Curvature of designed armadillo repeat proteins allows modular peptide binding
AP Simon Hansen, Patrick Ernst, Sebastian LB König, Christian Reichen ...
Journal of Structural Biology, 2017
14*2017
Rigid fusions of designed helical repeat binding proteins efficiently protect a binding surface from crystal contacts
P Ernst, A Honegger, F van der Valk, C Ewald, PRE Mittl, A Plückthun
Scientific reports 9 (1), 16162, 2019
102019
Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation. Nat Commun 8 (1): 45
T Afroz, EM Hock, P Ernst, C Foglieni, M Jambeau, L Gilhespy, ...
102017
Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization
N Friedrich, E Stiegeler, M Glögl, T Lemmin, S Hansen, C Kadelka, Y Wu, ...
Nature Communications 12 (1), 6705, 2021
92021
Structure-Guided Design of a Peptide Lock for Modular Peptide Binders
P Ernst, F Zosel, C Reichen, D Nettels, B Schuler, A Plückthun
ACS Chemical Biology 15 (2), 457-468, 2020
82020
The M23 peptidase domain of the Staphylococcal phage 2638A endolysin
M Dunne, P Ernst, A Sobieraj, A Pluckthun, MJ Loessner
(No Title), 2020
22020
Unexpected dynamics in femtomolar complexes of binding proteins with peptides
S Cucuzza, M Sitnik, S Jurt, E Michel, W Dai, T Müntener, P Ernst, ...
Nature communications 14 (1), 7823, 2023
12023
Heterodimerization of Endolysin Isoforms During Bacterial Infection by Staphylococcal Phage φ2638A
LV Zinsli, AM Sobieraj, P Ernst, S Meile, S Kilcher, C Iseli, A Keller, ...
bioRxiv, 2024.01. 16.575832, 2024
2024
A DARPin-based toolbox to understand and treat RAS-addicted cancers.
JN Kapp, JV Schaefer, W Verdurmen, G Nagy, R Degen, P Ernst, C Scholl, ...
MOLECULAR CANCER RESEARCH 18 (5), 66-66, 2020
2020
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Articles 1–20