| Intermittent fasting preserves beta-cell mass in obesity-induced diabetes via the autophagy-lysosome pathway H Liu, A Javaheri, RJ Godar, J Murphy, X Ma, N Rohatgi, J Mahadevan, ... Autophagy 13 (11), 1952-1968, 2017 | 177 | 2017 |
| Poly-dipeptides encoded by the C9ORF72 repeats block global protein translation K Kanekura, T Yagi, AJ Cammack, J Mahadevan, M Kuroda, MB Harms, ... Human molecular genetics 25 (9), 1803-1813, 2016 | 171 | 2016 |
| A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome S Lu, K Kanekura, T Hara, J Mahadevan, LD Spears, CM Oslowski, ... Proceedings of the National Academy of Sciences 111 (49), E5292-E5301, 2014 | 156 | 2014 |
| Calcium efflux from the endoplasmic reticulum leads to β-cell death T Hara, J Mahadevan, K Kanekura, M Hara, S Lu, F Urano Endocrinology 155 (3), 758-768, 2014 | 154 | 2014 |
| Autosomal dominant diabetes arising from a Wolfram syndrome 1 mutation LL Bonnycastle, PS Chines, T Hara, JR Huyghe, AJ Swift, P Heikinheimo, ... Diabetes 62 (11), 3943-3950, 2013 | 123 | 2013 |
| Ebselen treatment prevents islet apoptosis, maintains intranuclear Pdx-1 and MafA levels, and preserves β-cell mass and function in ZDF rats J Mahadevan, S Parazzoli, E Oseid, AV Hertzel, DA Bernlohr, SN Vallerie, ... Diabetes 62 (10), 3582-3588, 2013 | 96 | 2013 |
| Dominant ER Stress–Inducing WFS1 Mutations Underlie a Genetic Syndrome of Neonatal/Infancy-Onset Diabetes, Congenital Sensorineural Deafness, and … E De Franco, SE Flanagan, T Yagi, D Abreu, J Mahadevan, MB Johnson, ... Diabetes 66 (7), 2044-2053, 2017 | 85 | 2017 |
| Rpl13a small nucleolar RNAs regulate systemic glucose metabolism J Lee, AN Harris, CL Holley, J Mahadevan, KD Pyles, Z Lavagnino, ... The Journal of clinical investigation 126 (12), 4616-4625, 2016 | 84 | 2016 |
| Nrf2/antioxidant pathway mediates β cell self-repair after damage by high-fat diet–induced oxidative stress T Abebe, J Mahadevan, L Bogachus, S Hahn, M Black, E Oseid, F Urano, ... JCI insight 2 (24), 2017 | 44 | 2017 |
| Targeting cellular calcium homeostasis to prevent cytokine-mediated beta cell death AL Clark, K Kanekura, Z Lavagnino, LD Spears, D Abreu, J Mahadevan, ... Scientific reports 7 (1), 5611, 2017 | 32 | 2017 |
| Chromium picolinate induced apoptosis of lymphocytes and the signaling mechanisms thereof M Jana, A Rajaram, R Rajaram Toxicology and applied pharmacology 237 (3), 331-344, 2009 | 28 | 2009 |
| Silymarin activates c-AMP phosphodiesterase and stimulates insulin secretion in a glucose-dependent manner in HIT-T15 cells R Meng, J Mahadevan, E Oseid, S Vallerie, RP Robertson Antioxidants 5 (4), 47, 2016 | 13 | 2016 |
| A soluble endoplasmic reticulum factor as regenerative therapy for Wolfram syndrome J Mahadevan, S Morikawa, T Yagi, D Abreu, S Lu, K Kanekura, CM Brown, ... Laboratory Investigation 100 (9), 1197-1207, 2020 | 10 | 2020 |
| Autoschizis of T-cells is induced by the nutritional supplement, Cr (III) picolinate M Jana, R Rajaram, A Rajaram Toxicology in Vitro 24 (2), 586-596, 2010 | 9 | 2010 |
| Pancreatic stone protein/regenerating protein is a potential biomarker for endoplasmic reticulum stress in beta cells S Stone, D Abreu, J Mahadevan, R Asada, K Kries, R Graf, BA Marshall, ... Scientific reports 9 (1), 5199, 2019 | 7 | 2019 |
| Non-enzymatic phosphorylation of bovine serum albumin by Cr (V) complexes: Role in Cr (VI)-induced phosphorylation and toxicity C Vasant, S Sankaramanivel, M Jana, R Rajaram, T Ramasami Molecular and cellular biochemistry 275, 153-164, 2005 | 6 | 2005 |
| Age-related differences in the magnitude and time course of motoneuronal death following rat facial nerve avulsion IP Johnson, G Goldspink, G Turnbull, J Mahadevan, V Katharesan Society for Neuroscience Meeting, 2011 | 3 | 2011 |
| Ebselen, a Glutathione Peroxidase Mimetic, Prevents Fasting Hyperglycemia, Loss of Insulin Secretion, Increases beta-Cell Mass, and Preserves Intranuclear MafA and PDX-1 in ZDF … J Mahadevan, SD Parazzoli, EA Oseid, JS Harmon, A Hericks, ED Lynch, ... Diabetes 60, A273-A273, 2011 | 2 | 2011 |
| 10. Dantrolene as a Therapeutic Option for Wolfram Syndrome (134-OR) F Urano, S Lu, J Mahadevan, D Abreu, K Kanekura Nederlands Tijdschrift voor Diabetologie 13, 63-63, 2015 | 1 | 2015 |
| Treatment for Wolfram syndrome and other endoplasmic reticulum stress disorders F Urano, J Mahadevan, A Clark, A Jadhav, D Maloney, B Harvey, ... US Patent 11,426,415, 2022 | | 2022 |
Fumihiko UranoSamuel E. Schechter Professor of Medicine, Washington University School of MedicineVerified email at wustl.edu
