| Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling SMA Huang, YM Mishina, S Liu, A Cheung, F Stegmeier, GA Michaud, ... Nature 461 (7264), 614-620, 2009 | 2171 | 2009 |
| Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo WE Dowdle, B Nyfeler, J Nagel, RA Elling, S Liu, E Triantafellow, ... Nature cell biology 16 (11), 1069-1079, 2014 | 645 | 2014 |
| Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5 KJ Mavrakis, ER McDonald III, MR Schlabach, E Billy, GR Hoffman, ... Science 351 (6278), 1208-1213, 2016 | 423 | 2016 |
| SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice J Palacino, SE Swalley, C Song, AK Cheung, L Shu, X Zhang, ... Nature chemical biology 11 (7), 511-517, 2015 | 415 | 2015 |
| Integrating high-content screening and ligand-target prediction to identify mechanism of action DW Young, A Bender, J Hoyt, E McWhinnie, GW Chirn, CY Tao, ... Nature chemical biology 4 (1), 59-68, 2008 | 394 | 2008 |
| Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds Y Feng, TJ Mitchison, A Bender, DW Young, JA Tallarico Nature Reviews Drug Discovery 8 (7), 567-578, 2009 | 324 | 2009 |
| Harnessing the anti-cancer natural product nimbolide for targeted protein degradation JN Spradlin, X Hu, CC Ward, SM Brittain, MD Jones, L Ou, M To, ... Nature chemical biology 15 (7), 747-755, 2019 | 306 | 2019 |
| Natural products reveal cancer cell dependence on oxysterol-binding proteins AWG Burgett, TB Poulsen, K Wangkanont, DR Anderson, C Kikuchi, ... Nature chemical biology 7 (9), 639-647, 2011 | 254 | 2011 |
| Selective and specific inhibition of the Plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin D Hoepfner, CW McNamara, CS Lim, C Studer, R Riedl, T Aust, ... Cell host & microbe 11 (6), 654-663, 2012 | 239 | 2012 |
| Ring-opening metathesis. A ruthenium catalyst caught in the act JA Tallarico, PJ Bonitatebus, ML Snapper Journal of the American Chemical Society 119 (30), 7157-7158, 1997 | 237 | 1997 |
| Covalent ligand screening uncovers a RNF4 E3 ligase recruiter for targeted protein degradation applications CC Ward, JI Kleinman, SM Brittain, PS Lee, CYS Chung, K Kim, Y Petri, ... ACS chemical biology 14 (11), 2430-2440, 2019 | 230 | 2019 |
| Class III phosphatidylinositol 4-kinase alpha and beta are novel host factor regulators of hepatitis C virus replication J Borawski, P Troke, X Puyang, V Gibaja, SC Zhao, C Mickanin, ... Journal of virology 83 (19), 10058-10074, 2009 | 210 | 2009 |
| PIKfyve, a class III PI kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in Toll-like receptor signaling X Cai, Y Xu, AK Cheung, RC Tomlinson, A Alcázar-Román, L Murphy, ... Chemistry & biology 20 (7), 912-921, 2013 | 204 | 2013 |
| Small molecules that delay S phase suppress a zebrafish bmyb mutant HM Stern, RD Murphey, JL Shepard, JF Amatruda, CT Straub, KL Pfaff, ... Nature chemical biology 1 (7), 366-370, 2005 | 193 | 2005 |
| High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions D Hoepfner, SB Helliwell, H Sadlish, S Schuierer, I Filipuzzi, S Brachat, ... Microbiological research 169 (2-3), 107-120, 2014 | 163 | 2014 |
| Deubiquitinase-targeting chimeras for targeted protein stabilization NJ Henning, L Boike, JN Spradlin, CC Ward, G Liu, E Zhang, BP Belcher, ... Nature chemical biology 18 (4), 412-421, 2022 | 153 | 2022 |
| A one-bead, one-stock solution approach to chemical genetics: part 1 HE Blackwell, L Pérez, RA Stavenger, JA Tallarico, EC Eatough, ... Chemistry & biology 8 (12), 1167-1182, 2001 | 153 | 2001 |
| Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62 R DeJesus, F Moretti, G McAllister, Z Wang, P Bergman, S Liu, E Frias, ... Elife 5, e17290, 2016 | 140 | 2016 |
| An alkylsilyl-tethered, high-capacity solid support amenable to diversity-oriented synthesis for one-bead, one-stock solution chemical genetics JA Tallarico, KM Depew, HE Pelish, NJ Westwood, CW Lindsley, ... Journal of combinatorial chemistry 3 (3), 312-318, 2001 | 136 | 2001 |
| Selective ring-opening cross-metathesis. Short syntheses of multifidene and viridiene ML Randall, JA Tallarico, ML Snapper Journal of the American Chemical Society 117 (37), 9610-9611, 1995 | 133 | 1995 |
Jeff McKennaNovartisVerified email at novartis.com
