| Natural selection has driven population differentiation in modern humans LB Barreiro, G Laval, H Quach, E Patin, L Quintana-Murci Nature genetics 40 (3), 340-345, 2008 | 800 | 2008 |
| Autoantibodies neutralizing type I IFNs are present in~ 4% of uninfected individuals over 70 years old and account for~ 20% of COVID-19 deaths P Bastard, A Gervais, T Le Voyer, J Rosain, Q Philippot, J Manry, ... Science immunology 6 (62), eabl4340, 2021 | 521 | 2021 |
| Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense LB Barreiro, M Ben-Ali, H Quach, G Laval, E Patin, JK Pickrell, C Bouchier, ... PLoS genetics 5 (7), e1000562, 2009 | 468 | 2009 |
| Genetic adaptation and neandertal admixture shaped the immune system of human populations H Quach, M Rotival, J Pothlichet, YHE Loh, M Dannemann, N Zidane, ... Cell 167 (3), 643-656. e17, 2016 | 440 | 2016 |
| Genomic signatures of selective pressures and introgression from archaic hominins at human innate immunity genes M Deschamps, G Laval, M Fagny, Y Itan, L Abel, JL Casanova, E Patin, ... The American Journal of Human Genetics 98 (1), 5-21, 2016 | 293 | 2016 |
| Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors E Patin, M Hasan, J Bergstedt, V Rouilly, V Libri, A Urrutia, C Alanio, ... Nature immunology 19 (3), 302-314, 2018 | 289 | 2018 |
| Dispersals and genetic adaptation of Bantu-speaking populations in Africa and North America E Patin, M Lopez, R Grollemund, P Verdu, C Harmant, H Quach, G Laval, ... Science 356 (6337), 543-546, 2017 | 272 | 2017 |
| The human gene damage index as a gene-level approach to prioritizing exome variants Y Itan, L Shang, B Boisson, E Patin, A Bolze, M Moncada-Vélez, E Scott, ... Proceedings of the National Academy of Sciences 112 (44), 13615-13620, 2015 | 264 | 2015 |
| Maternal traces of deep common ancestry and asymmetric gene flow between Pygmy hunter–gatherers and Bantu-speaking farmers L Quintana-Murci, H Quach, C Harmant, F Luca, B Massonnet, E Patin, ... Proceedings of the National Academy of Sciences 105 (5), 1596-1601, 2008 | 244 | 2008 |
| Inferring the demographic history of African farmers and Pygmy hunter–gatherers using a multilocus resequencing data set E Patin, G Laval, LB Barreiro, A Salas, O Semino, ... PLoS genetics 5 (4), e1000448, 2009 | 227 | 2009 |
| Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges B Piasecka, D Duffy, A Urrutia, H Quach, E Patin, C Posseme, J Bergstedt, ... Proceedings of the National Academy of Sciences 115 (3), E488-E497, 2018 | 220 | 2018 |
| Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection E Patin, Z Kutalik, J Guergnon, S Bibert, B Nalpas, E Jouanguy, ... Gastroenterology 143 (5), 1244-1252. e12, 2012 | 213 | 2012 |
| Evolutionary genetic dissection of human interferons J Manry, G Laval, E Patin, S Fornarino, Y Itan, M Fumagalli, M Sironi, ... Journal of Experimental Medicine 208 (13), 2747-2759, 2011 | 210 | 2011 |
| Positively selected G6PD-Mahidol mutation reduces Plasmodium vivax density in Southeast Asians C Louicharoen, E Patin, R Paul, I Nuchprayoon, B Witoonpanich, ... Science 326 (5959), 1546-1549, 2009 | 203 | 2009 |
| Ribosomal protein SA haploinsufficiency in humans with isolated congenital asplenia A Bolze, N Mahlaoui, M Byun, B Turner, N Trede, SR Ellis, A Abhyankar, ... Science 340 (6135), 976-978, 2013 | 200 | 2013 |
| IL28B alleles associated with poor hepatitis C virus (HCV) clearance protect against inflammation and fibrosis in patients infected with non‐1 HCV genotypes PY Bochud, S Bibert, Z Kutalik, E Patin, J Guergnon, B Nalpas, ... Hepatology 55 (2), 384-394, 2012 | 199 | 2012 |
| Tuberculosis and impaired IL-23–dependent IFN-γ immunity in humans homozygous for a common TYK2 missense variant S Boisson-Dupuis, N Ramirez-Alejo, Z Li, E Patin, G Rao, G Kerner, ... Science immunology 3 (30), eaau8714, 2018 | 193 | 2018 |
| Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23 R Martínez-Barricarte, JG Markle, CS Ma, EK Deenick, N Ramírez-Alejo, ... Science immunology 3 (30), eaau6759, 2018 | 182 | 2018 |
| Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines P Scepanovic, C Alanio, C Hammer, F Hodel, J Bergstedt, E Patin, ... Genome medicine 10, 1-13, 2018 | 166 | 2018 |
| Human RHOH deficiency causes T cell defects and susceptibility to EV-HPV infections A Crequer, A Troeger, E Patin, CS Ma, C Picard, V Pedergnana, C Fieschi, ... The Journal of clinical investigation 122 (9), 3239-3247, 2012 | 160 | 2012 |
Guillaume LavalInsitut PasteurVerified email at pasteur.fr
