| Transneuronal propagation of pathologic α-synuclein from the gut to the brain models Parkinson’s disease S Kim, SH Kwon, TI Kam, N Panicker, SS Karuppagounder, S Lee, JH Lee, ... Neuron 103 (4), 627-641. e7, 2019 | 1037 | 2019 |
| Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease SP Yun, TI Kam, N Panicker, SM Kim, Y Oh, JS Park, SH Kwon, YJ Park, ... Nature medicine 24 (7), 931-938, 2018 | 848 | 2018 |
| Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3 X Mao, MT Ou, SS Karuppagounder, TI Kam, X Yin, Y Xiong, P Ge, ... Science 353 (6307), aah3374, 2016 | 675 | 2016 |
| Poly (ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson’s disease TI Kam, X Mao, H Park, SC Chou, SS Karuppagounder, GE Umanah, ... Science 362 (6414), eaat8407, 2018 | 393 | 2018 |
| Poly (ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis SA Andrabi, GKE Umanah, C Chang, DA Stevens, SS Karuppagounder, ... Proceedings of the National Academy of Sciences 111 (28), 10209-10214, 2014 | 339 | 2014 |
| Sulfhydration mediates neuroprotective actions of parkin MS Vandiver, BD Paul, R Xu, S Karuppagounder, F Rao, AM Snowman, ... Nature communications 4 (1), 1626, 2013 | 313 | 2013 |
| Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function HS Ko, Y Lee, JH Shin, SS Karuppagounder, BS Gadad, AJ Koleske, ... Proceedings of the National Academy of Sciences 107 (38), 16691-16696, 2010 | 305 | 2010 |
| The c-Abl inhibitor, nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease SS Karuppagounder, S Brahmachari, Y Lee, VL Dawson, TM Dawson, ... Scientific reports 4 (1), 4874, 2014 | 243 | 2014 |
| Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss Y Lee, SS Karuppagounder, JH Shin, YI Lee, HS Ko, D Swing, H Jiang, ... Nature neuroscience 16 (10), 1392-1400, 2013 | 207 | 2013 |
| GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers S Kim, SP Yun, S Lee, GE Umanah, VVR Bandaru, X Yin, P Rhee, ... Proceedings of the National Academy of Sciences 115 (4), 798-803, 2018 | 176 | 2018 |
| Activation of tyrosine kinase c-Abl contributes to α-synuclein–induced neurodegeneration S Brahmachari, P Ge, SH Lee, D Kim, SS Karuppagounder, M Kumar, ... The Journal of clinical investigation 126 (8), 2970-2988, 2016 | 164 | 2016 |
| Genetic deficiency of the mitochondrial protein PGAM5 causes a Parkinson’s-like movement disorder W Lu, SS Karuppagounder, DA Springer, MD Allen, L Zheng, B Chao, ... Nature communications 5 (1), 4930, 2014 | 140 | 2014 |
| Versatile effects of sildenafil: recent pharmacological applications S Uthayathas, SS Karuppagounder, BM Thrash, K Parameshwaran, ... Pharmacological reports 59 (2), 150, 2007 | 130 | 2007 |
| MicroRNA-132 dysregulation in Toxoplasma gondii infection has implications for dopamine signaling pathway J Xiao, Y Li, E Prandovszky, SS Karuppagounder, CC Talbot Jr, ... Neuroscience 268, 128-138, 2014 | 115 | 2014 |
| Central insulin resistance and synaptic dysfunction in intracerebroventricular-streptozotocin injected rodents BC Shonesy, K Thiruchelvam, K Parameshwaran, EA Rahman, ... Neurobiology of aging 33 (2), 430. e5-430. e18, 2012 | 114 | 2012 |
| L-deprenyl protects against rotenone-induced, oxidative stress-mediated dopaminergic neurodegeneration in rats KS Saravanan, KM Sindhu, KS Senthilkumar, KP Mohanakumar Neurochemistry international 49 (1), 28-40, 2006 | 92 | 2006 |
| α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism SP Yun, D Kim, S Kim, SM Kim, SS Karuppagounder, SH Kwon, S Lee, ... Molecular neurodegeneration 13, 1-19, 2018 | 84 | 2018 |
| Robust kinase-and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice Y Xiong, S Neifert, SS Karuppagounder, Q Liu, JN Stankowski, BD Lee, ... Proceedings of the National Academy of Sciences 115 (7), 1635-1640, 2018 | 84 | 2018 |
| Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson’s disease N Panicker, TI Kam, H Wang, S Neifert, SC Chou, M Kumar, ... Neuron 110 (15), 2422-2437. e9, 2022 | 82 | 2022 |
| c-Abl and Parkinson’s disease: mechanisms and therapeutic potential S Brahmachari, SS Karuppagounder, P Ge, S Lee, VL Dawson, ... Journal of Parkinson's Disease 7 (4), 589-601, 2017 | 82 | 2017 |
Valina L. DawsonProfessor of Neurology, Neuroscience and Physiology, Johns Hopkins University School of MedicineVerified email at jhmi.edu
