jan steyaert
jan steyaert
VIB-VUB center for Structural Biology, Brussels
Verified email at vub.ac.be - Homepage
Title
Cited by
Cited by
Year
Crystal structure of the β2 adrenergic receptor-Gs protein complex
SGF Rasmussen, BT DeVree, Y Zou, AC Kruse, KY Chung, TS Kobilka, ...
Nature 477 (7366), 549-555, 2011
28192011
Structure of a nanobody-stabilized active state of the β2 adrenoceptor
SGF Rasmussen, HJ Choi, JJ Fung, E Pardon, P Casarosa, PS Chae, ...
Nature 469 (7329), 175-180, 2011
16512011
Activation and allosteric modulation of a muscarinic acetylcholine receptor
AC Kruse, AM Ring, A Manglik, J Hu, K Hu, K Eitel, H HŘbner, E Pardon, ...
Nature 504 (7478), 101-106, 2013
7572013
Structural insights into Á-opioid receptor activation
W Huang, A Manglik, AJ Venkatakrishnan, T Laeremans, EN Feinberg, ...
Nature 524 (7565), 315-321, 2015
6322015
Conformational biosensors reveal GPCR signalling from endosomes
R Irannejad, JC Tomshine, JR Tomshine, M Chevalier, JP Mahoney, ...
Nature 495 (7442), 534–538, 2013
6292013
A general protocol for the generation of Nanobodies for structural biology
E Pardon, T Laeremans, S Triest, SGF Rasmussen, A Wohlk÷nig, A Ruf, ...
Nature protocols 9 (3), 674-693, 2014
4402014
The F plasmid CcdB protein induces efficient ATP-dependent DNA cleavage by gyrase
P Bernard, KE KÚzdy, L Van Melderen, J Steyaert, L Wyns, ML Pato, ...
Journal of molecular biology 234 (3), 534-541, 1993
3061993
Structural flexibility of the Gαs α-helical domain in the β2-adrenoceptor Gs complex
GH Westfield, SGF Rasmussen, M Su, S Dutta, BT DeVree, KY Chung, ...
Proceedings of the National Academy of Sciences 108 (38), 16086-16091, 2011
2412011
Influence of the π–π interaction on the hydrogen bonding capacity of stacked DNA/RNA bases
P Mignon, S Loverix, J Steyaert, P Geerlings
Nucleic acids research 33 (6), 1779-1789, 2005
2372005
GABAA receptor signalling mechanisms revealed by structural pharmacology
S Masiulis, R Desai, T Uchański, IS Martin, D Laverty, D Karia, ...
Nature 565, 454-459, 2019
2302019
Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation
DP Staus, RT Strachan, A Manglik, B Pani, AW Kahsai, TH Kim, ...
Nature 535 (7612), 448-452, 2016
2272016
Therapeutic nanoreactors: combining chemistry and biology in a novel triblock copolymer drug delivery system
A Ranquin, W VersÚes, W Meier, J Steyaert, P Van Gelder
Nano letters 5 (11), 2220-2224, 2005
2262005
Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain
AB Ward, P Szewczyk, V Grimard, CW Lee, L Martinez, R Doshi, A Caya, ...
Proceedings of the National Academy of Sciences 110 (33), 13386-13391, 2013
2252013
Nanobody stabilization of G protein-coupled receptor conformational states
J Steyaert, BK Kobilka
Current opinion in structural biology 21 (4), 567-572, 2011
2252011
Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor
T Che, S Majumdar, SA Zaidi, P Ondachi, JD McCorvy, S Wang, ...
Cell 172, 55–67, 2018
2142018
Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis
TJ Cahill, ARB Thomsen, JT Tarrasch, B Plouffe, AH Nguyen, F Yang, ...
Proceedings of the National Academy of Sciences 114, 2562-2567, 2017
2062017
Crystal structure of the N-terminal domain of the secretin GspD from ETEC determined with the assistance of a nanobody
KV Korotkov, E Pardon, J Steyaert, WGJ Hol
Structure 17 (2), 255-265, 2009
2062009
Propagation of conformational changes during Á-opioid receptor activation
R Sounier, C Mas, J Steyaert, T Laeremans, A Manglik, W Huang, ...
Nature 524 (7565), 375-378, 2015
2012015
Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes
K Rostislavleva, N Soler, Y Ohashi, L Zhang, E Pardon, JE Burke, ...
Science 350 (6257), 2015
1762015
Allosteric coupling from G protein to the agonist-binding pocket in GPCRs
BT DeVree, JP Mahoney, GA VÚlez-Ruiz, SGF Rasmussen, AJ Kuszak, ...
Nature 535 (7610), 182-186, 2016
1712016
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