Jacob Lund
Jacob Lund
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Mutations in calmodulin cause ventricular tachycardia and sudden cardiac death
M Nyegaard, MT Overgaard, MT Søndergaard, M Vranas, ER Behr, ...
The American Journal of Human Genetics 91 (4), 703-712, 2012
ADAMDEC1 is a metzincin metalloprotease with dampened proteolytic activity
J Lund, OH Olsen, ES Sørensen, HR Stennicke, HH Petersen, ...
Journal of Biological Chemistry 288 (29), 21367-21375, 2013
Heparin-binding mechanism of the IGF2/IGF-binding protein 2 complex
J Lund, MT Søndergaard, CA Conover, MT Overgaard
J Mol Endocrinol 52 (3), 345-55, 2014
Mim8-A next-generation FVIII mimetic bi-specific antibody-potently restores the hemostatic capacity in hemophilia a settings in vitro and in vivo
SL Kjellev, H Østergaard, MB Hermit, K Thorn, BG Hansen, R Zhou, ...
Blood 134, 96, 2019
Evidence for restricted reactivity of ADAMDEC1 with protein substrates and endogenous inhibitors
J Lund, L Troeberg, H Kjeldal, OH Olsen, H Nagase, ES Sørensen, ...
Journal of Biological Chemistry 290 (10), 6620-6629, 2015
A factor VIIIa–mimetic bispecific antibody, Mim8, ameliorates bleeding upon severe vascular challenge in hemophilia A mice
H Østergaard, J Lund, PJ Greisen, S Kjellev, A Henriksen, N Lorenzen, ...
blood 138 (14), 1258-1268, 2021
Monoclonal antibodies targeting the disintegrin-like domain of ADAMDEC1 modulates the proteolytic activity and enables quantification of ADAMDEC1 protein in human plasma
J Lund, AM Elimar Bitsch, M Grønbech Rasch, M Enoksson, L Troeberg, ...
MAbs 10 (1), 118-128, 2018
Modulation of the activated protein C pathway in severe haemophilia A patients: The effects of thrombomodulin and a factor V‐stabilizing fab
DF Brophy, EJ Martin, BM Mohammed, JC Barrett, JG Kuhn, ME Nolte, ...
Haemophilia 23 (6), 941-947, 2017
The functional role of the autolysis loop in the regulation of factor X upon hemostatic response
AC Bonde, J Lund, JJ Hansen, JR Winther, PF Nielsen, S Zahn, P Tiainen, ...
Journal of Thrombosis and Haemostasis 20 (3), 589-599, 2022
Site‐specific functional roles of the Factor X activation peptide in the intrinsic tenase‐mediated Factor X activation
A Carnbring Bonde, S Rosenørn Hansen, E Johansson, J Rose Bjelke, ...
FEBS Letters 596 (12), 1567-1575, 2022
A systematic approach for evaluating the role of surface-exposed loops in trypsin-like serine proteases applied to the 170 loop in coagulation factor VIIa
AB Sorensen, P Greisen Jr, JJ Madsen, J Lund, G Andersen, ...
Scientific reports 12 (1), 1-12, 2022
Site-specific functional roles of the Factor X activation peptide in the intrinsic tenase-mediated Factor X activation.
AC Bonde, SR Hansen, E Johansson, JR Bjelke, J Lund
FEBS letters, 2022
Factor x binders enhancing fx activation
J Lund, K Thorn, MN Harndahl, MA Buyse, E De Tavernier, S Steffensen
US Patent App. 16/764,124, 2021
Prolonging coagulant activity of factor Xa under hemophilic conditions by site-specific N-glycosylation of the surface-exposed autolysis loop
AC Bonde, J Lund, JJ Hansen, JR Winther, S Zahn, P Tiainen, OH Olsen, ...
bioRxiv, 2021
Liants de facteur x renforçant l'activation fx
MA Buyse, MN Harndahl, J Lund, S Steffensen, E De Tavernier, K Thorn
Mette Nyegaard,* Michael T. Overgaard, 2, 8 Mads T. Søndergaard, 2 Marta Vranas, Elijah R. Behr, 3
LL Hildebrandt, J Lund, PL Hedley, AJ Camm, G Wettrell, I Fosdal, ...
The American Journal of Human Genetics 91, 703-712, 2012
Development of Real Time Proteolytic Assays using Fluorescent Protein Substrates
SH Jensen, J Lund, MT Overgaard
Heparin binding properties of the IGF-II/IGFBP-2 complex
J Lund, MT Søndergaard, SH Jensen, F Aasted, EK Andresen, ...
OR6, 35 Heparin binding properties of the IGF-II/IGFBP-2 complex
J Lund, MT Søndergaard, SH Jensen, F Aasted, EK Andresen, ...
Growth Hormone & IGF Research, S15-S16, 2010
A Novel Anabolic Therapy for Osteoporosis
J Lund, MB Brøndum, MT Søndergaard, MT Overgaard
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