Tombline, Gregory
Tombline, Gregory
University of Rochester Biology
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BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance
A Slupianek, C Schmutte, G Tombline, M Nieborowska-Skorska, G Hoser, ...
Molecular cell 8 (4), 795-806, 2001
BRCA1, BRCA2, and DNA damage response: collision or collusion?
H Zhang, G Tombline, BL Weber
Cell 92 (4), 433, 1998
DNA: REPLICATION, REPAIR, AND RECOMBINATION-Biochemical characterization of the human RAD51 protein. III. Modulation of DNA binding by adenosine nucleotides.
G Tombline, CD Heinen, KS Shim, R Fishel
Journal of Biological Chemistry 277 (17), 14434-14442, 2002
Combined mutation of catalytic glutamate residues in the two nucleotide binding domains of P-glycoprotein generates a conformation that binds ATP and ADP tightly
G Tombline, LA Bartholomew, IL Urbatsch, AE Senior
Journal of Biological Chemistry 279 (30), 31212-31220, 2004
P-glycoprotein catalytic mechanism: studies of the ADP-vanadate inhibited state
IL Urbatsch, GA Tyndall, G Tombline, AE Senior
Journal of Biological Chemistry 278 (25), 23171-23179, 2003
Involvement of the “occluded nucleotide conformation” of P-glycoprotein in the catalytic pathway
G Tombline, A Muharemagić, LB White, AE Senior
Biochemistry 44 (38), 12879-12886, 2005
SIRT6 is responsible for more efficient DNA double-strand break repair in long-lived species
X Tian, D Firsanov, Z Zhang, Y Cheng, L Luo, G Tombline, R Tan, ...
Cell 177 (3), 622-638. e22, 2019
Properties of P-glycoprotein with mutations in the “catalytic carboxylate” glutamate residues
G Tombline, LA Bartholomew, GA Tyndall, K Gimi, IL Urbatsch, AE Senior
Journal of Biological Chemistry 279 (45), 46518-46526, 2004
Synergy between conserved ABC signature Ser residues in P-glycoprotein catalysis
G Tombline, L Bartholomew, K Gimi, GA Tyndall, AE Senior
Journal of Biological Chemistry 279 (7), 5363-5373, 2004
JNK phosphorylates SIRT6 to stimulate DNA double-strand break repair in response to oxidative stress by recruiting PARP1 to DNA breaks
M Van Meter, M Simon, G Tombline, A May, TD Morello, BP Hubbard, ...
Cell reports 16 (10), 2641-2650, 2016
Rhodamine inhibitors of P-glycoprotein: an amide/thioamide “switch” for ATPase activity
MK Gannon, JJ Holt, SM Bennett, BR Wetzel, TW Loo, MC Bartlett, ...
Journal of medicinal chemistry 52 (10), 3328-3341, 2009
Characterization of the human Rad51 genomic locus and examination of tumors with 15q14–15 loss of heterozygosity (LOH)
C Schmutte, G Tombline, K Rhiem, MM Sadoff, R Schmutzler, ...
Cancer research 59 (18), 4564-4569, 1999
Nucleotide binding to the multidrug resistance P-glycoprotein as studied by ESR spectroscopy
S Delannoy, IL Urbatsch, G Tombline, AE Senior, PD Vogel
Biochemistry 44 (42), 14010-14019, 2005
hXRCC2 enhances ADP/ATP processing and strand exchange by hRAD51
KS Shim, C Schmutte, G Tombline, CD Heinen, R Fishel
Journal of Biological Chemistry 279 (29), 30385-30394, 2004
The occluded nucleotide conformation of P-glycoprotein
G Tombline, AE Senior
Journal of bioenergetics and biomembranes 37 (6), 497-500, 2005
Heterogeneity of primer extension products in asymmetric PCR is due both to cleavage by a structure-specific exo/endonuclease activity of DNA polymerases and to premature stops
G Tombline, D Bellizzi, V Sgaramella
Proceedings of the National Academy of Sciences 93 (7), 2724-2728, 1996
Naked mole rat cells have a stable epigenome that resists iPSC reprogramming
L Tan, Z Ke, G Tombline, N Macoretta, K Hayes, X Tian, R Lv, J Ablaeva, ...
Stem cell reports 9 (5), 1721-1734, 2017
Production of stable isotope-labeled acyl-coenzyme A thioesters by yeast stable isotope labeling by essential nutrients in cell culture
NW Snyder, G Tombline, AJ Worth, RC Parry, JA Silvers, KP Gillespie, ...
Analytical biochemistry 474, 59-65, 2015
Stimulation of P-glycoprotein ATPase by analogues of tetramethylrosamine: coupling of drug binding at the “R” site to the ATP hydrolysis transition state
G Tombline, DJ Donnelly, JJ Holt, Y You, M Ye, MK Gannon, CL Nygren, ...
Biochemistry 45 (26), 8034-8047, 2006
Pseudomonas aeruginosa PA1006, which plays a role in molybdenum homeostasis, is required for nitrate utilization, biofilm formation, and virulence
MJ Filiatrault, G Tombline, VE Wagner, N Van Alst, K Rumbaugh, P Sokol, ...
PLoS One 8 (2), e55594, 2013
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