| BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance A Slupianek, C Schmutte, G Tombline, M Nieborowska-Skorska, G Hoser, ... Molecular cell 8 (4), 795-806, 2001 | 398 | 2001 |
| SIRT6 is responsible for more efficient DNA double-strand break repair in long-lived species X Tian, D Firsanov, Z Zhang, Y Cheng, L Luo, G Tombline, R Tan, ... Cell 177 (3), 622-638. e22, 2019 | 244 | 2019 |
| BRCA1, BRCA2, and DNA damage response: collision or collusion? H Zhang, G Tombline, BL Weber Cell 92 (4), 433, 1998 | 219 | 1998 |
| DNA: REPLICATION, REPAIR, AND RECOMBINATION-Biochemical characterization of the human RAD51 protein. III. Modulation of DNA binding by adenosine nucleotides. G Tombline, CD Heinen, KS Shim, R Fishel Journal of Biological Chemistry 277 (17), 14434-14442, 2002 | 145* | 2002 |
| JNK phosphorylates SIRT6 to stimulate DNA double-strand break repair in response to oxidative stress by recruiting PARP1 to DNA breaks M Van Meter, M Simon, G Tombline, A May, TD Morello, BP Hubbard, ... Cell reports 16 (10), 2641-2650, 2016 | 133 | 2016 |
| Combined mutation of catalytic glutamate residues in the two nucleotide binding domains of P-glycoprotein generates a conformation that binds ATP and ADP tightly G Tombline, LA Bartholomew, IL Urbatsch, AE Senior Journal of Biological Chemistry 279 (30), 31212-31220, 2004 | 120 | 2004 |
| P-glycoprotein catalytic mechanism: studies of the ADP-vanadate inhibited state IL Urbatsch, GA Tyndall, G Tombline, AE Senior Journal of Biological Chemistry 278 (25), 23171-23179, 2003 | 115 | 2003 |
| Involvement of the “occluded nucleotide conformation” of P-glycoprotein in the catalytic pathway G Tombline, A Muharemagić, LB White, AE Senior Biochemistry 44 (38), 12879-12886, 2005 | 97 | 2005 |
| Properties of P-glycoprotein with mutations in the “catalytic carboxylate” glutamate residues G Tombline, LA Bartholomew, GA Tyndall, K Gimi, IL Urbatsch, AE Senior Journal of Biological Chemistry 279 (45), 46518-46526, 2004 | 93 | 2004 |
| Naked mole rat cells have a stable epigenome that resists iPSC reprogramming L Tan, Z Ke, G Tombline, N Macoretta, K Hayes, X Tian, R Lv, J Ablaeva, ... Stem cell reports 9 (5), 1721-1734, 2017 | 91 | 2017 |
| Synergy between conserved ABC signature Ser residues in P-glycoprotein catalysis G Tombline, L Bartholomew, K Gimi, GA Tyndall, AE Senior Journal of Biological Chemistry 279 (7), 5363-5373, 2004 | 85 | 2004 |
| Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties M Takasugi, D Firsanov, G Tombline, H Ning, J Ablaeva, A Seluanov, ... Nature communications 11 (1), 2376, 2020 | 81 | 2020 |
| Rhodamine inhibitors of P-glycoprotein: an amide/thioamide “switch” for ATPase activity MK Gannon, JJ Holt, SM Bennett, BR Wetzel, TW Loo, MC Bartlett, ... Journal of medicinal chemistry 52 (10), 3328-3341, 2009 | 73 | 2009 |
| SIRT6 promotes transcription of a subset of NRF2 targets by mono-ADP-ribosylating BAF170 S Rezazadeh, D Yang, G Tombline, M Simon, SP Regan, A Seluanov, ... Nucleic acids research 47 (15), 7914-7928, 2019 | 71 | 2019 |
| Characterization of the human Rad51 genomic locus and examination of tumors with 15q14–15 loss of heterozygosity (LOH) C Schmutte, G Tombline, K Rhiem, MM Sadoff, R Schmutzler, ... Cancer research 59 (18), 4564-4569, 1999 | 65 | 1999 |
| Production of stable isotope-labeled acyl-coenzyme A thioesters by yeast stable isotope labeling by essential nutrients in cell culture NW Snyder, G Tombline, AJ Worth, RC Parry, JA Silvers, KP Gillespie, ... Analytical biochemistry 474, 59-65, 2015 | 59 | 2015 |
| Nucleotide binding to the multidrug resistance P-glycoprotein as studied by ESR spectroscopy S Delannoy, IL Urbatsch, G Tombline, AE Senior, PD Vogel Biochemistry 44 (42), 14010-14019, 2005 | 58 | 2005 |
| hXRCC2 enhances ADP/ATP processing and strand exchange by hRAD51 KS Shim, C Schmutte, G Tombline, CD Heinen, R Fishel Journal of Biological Chemistry 279 (29), 30385-30394, 2004 | 58 | 2004 |
| The occluded nucleotide conformation of P-glycoprotein G Tombline, AE Senior Journal of bioenergetics and biomembranes 37, 497-500, 2005 | 55 | 2005 |
| Heterogeneity of primer extension products in asymmetric PCR is due both to cleavage by a structure-specific exo/endonuclease activity of DNA polymerases and to premature stops. G Tombline, D Bellizzi, V Sgaramella Proceedings of the National Academy of Sciences 93 (7), 2724-2728, 1996 | 50 | 1996 |
John LapekPrincipal ScientistVerified email at belharratx.com
