A versatile and scalable two-step ion-exchange chromatography process for the purification of recombinant adeno-associated virus serotypes-2 and-5 N Brument, R Morenweiser, V Blouin, E Toublanc, I Raimbaud, Y Chérel, ... Molecular Therapy 6 (5), 678-686, 2002 | 181 | 2002 |
Lack of an immune response against the tetracycline-dependent transactivator correlates with long-term doxycycline-regulated transgene expression in nonhuman primates after … D Favre, V Blouin, N Provost, R Spisek, F Porrot, D Bohl, F Marmé, ... Journal of virology 76 (22), 11605-11611, 2002 | 165 | 2002 |
Characterization of a recombinant adeno-associated virus type 2 Reference Standard Material M Lock, S McGorray, A Auricchio, E Ayuso, EJ Beecham, V Blouin-Tavel, ... Mary Ann Liebert, Inc. 140 Huguenot Street, 3rd Floor New Rochelle, NY 10801 USA, 2010 | 161 | 2010 |
Immediate and long-term safety of recombinant adeno-associated virus injection into the nonhuman primate muscle D Favre, N Provost, V Blouin, G Blancho, Y Chérel, A Salvetti, P Moullier Molecular therapy 4 (6), 559-566, 2001 | 149 | 2001 |
The role of the adeno-associated virus capsid in gene transfer KM Van Vliet, V Blouin, N Brument, M Agbandje-McKenna, RO Snyder Drug Delivery Systems, 51-91, 2008 | 144 | 2008 |
Practical utilization of recombinant AAV vector reference standards: focus on vector genomes titration by free ITR qPCR S d'Costa, V Blouin, F Broucque, M Penaud-Budloo, A Fçranois, IC Perez, ... Molecular Therapy Methods & Clinical Development 3, 2016 | 120 | 2016 |
Efficient CNS targeting in adult mice by intrathecal infusion of single-stranded AAV9-GFP for gene therapy of neurological disorders K Bey, C Ciron, L Dubreil, J Deniaud, M Ledevin, J Cristini, V Blouin, ... Gene therapy 24 (5), 325-332, 2017 | 95 | 2017 |
Manufacturing and characterization of a recombinant adeno-associated virus type 8 reference standard material E Ayuso, V Blouin, M Lock, S McGorray, X Leon, MR Alvira, A Auricchio, ... Human gene therapy 25 (11), 977-987, 2014 | 94 | 2014 |
Liver-specific transcriptional modules identified by genome-wide in silico analysis enable efficient gene therapy in mice and non-human primates MK Chuah, I Petrus, P De Bleser, C Le Guiner, G Gernoux, O Adjali, ... Molecular Therapy 22 (9), 1605-1613, 2014 | 86 | 2014 |
Improving rAAV production and purification: towards the definition of a scaleable process V Blouin, N Brument, E Toublanc, I Raimbaud, P Moullier, A Salvetti The Journal of Gene Medicine: A cross‐disciplinary journal for research on …, 2004 | 81 | 2004 |
AAV-ID: a rapid and robust assay for batch-to-batch consistency evaluation of AAV preparations S Pacouret, M Bouzelha, R Shelke, E Andres-Mateos, R Xiao, A Maurer, ... Molecular Therapy 25 (6), 1375-1386, 2017 | 78 | 2017 |
Advanced characterization of DNA molecules in rAAV vector preparations by single-stranded virus next-generation sequencing E Lecomte, B Tournaire, B Cogné, JB Dupont, P Lindenbaum, ... Molecular Therapy-Nucleic Acids 4, 2015 | 77 | 2015 |
Efficient central nervous system AAVrh10-mediated intrathecal gene transfer in adult and neonate rats J Hordeaux, L Dubreil, J Deniaud, F Iacobelli, S Moreau, M Ledevin, ... Gene therapy 22 (4), 316-324, 2015 | 73 | 2015 |
Intra-CSF AAV9 and AAVrh10 administration in nonhuman primates: promising routes and vectors for which neurological diseases? K Bey, J Deniaud, L Dubreil, B Joussemet, J Cristini, C Ciron, J Hordeaux, ... Molecular Therapy Methods & Clinical Development 17, 771-784, 2020 | 65 | 2020 |
MyD88 signaling in B cells regulates the production of Th1-dependent antibodies to AAV M Sudres, S Ciré, V Vasseur, L Brault, S Da Rocha, F Boisgérault, ... Molecular Therapy 20 (8), 1571-1581, 2012 | 65 | 2012 |
Accurate identification and quantification of DNA species by next-generation sequencing in adeno-associated viral vectors produced in insect cells M Penaud-Budloo, E Lecomte, A Guy-Duché, S Saleun, A Roulet, ... Human gene therapy methods 28 (3), 148-162, 2017 | 63 | 2017 |
Chemical modification of the adeno-associated virus capsid to improve gene delivery M Mével, M Bouzelha, A Leray, S Pacouret, M Guilbaud, ... Chemical science 11 (4), 1122-1131, 2020 | 55 | 2020 |
Accurate titration of infectious AAV particles requires measurement of biologically active vector genomes and suitable controls A François, M Bouzelha, E Lecomte, F Broucque, M Penaud-Budloo, ... Molecular Therapy-Methods & Clinical Development 10, 223-236, 2018 | 53 | 2018 |
Hyaluronidase enhances recombinant adeno-associated virus (rAAV)-mediated gene transfer in the rat skeletal muscle D Favre, Y Cherel, N Provost, V Blouin, N Ferry, P Moullier, A Salvetti Gene therapy 7 (16), 1417-1420, 2000 | 46 | 2000 |
Human and insect cell-produced recombinant adeno-associated viruses show differences in genome heterogeneity NT Tran, E Lecomte, S Saleun, S Namkung, C Robin, K Weber, E Devine, ... Human Gene Therapy 33 (7-8), 371-388, 2022 | 41 | 2022 |