| Inhibition of dihydroorotate dehydrogenase overcomes differentiation blockade in acute myeloid leukemia DB Sykes, YS Kfoury, FE Mercier, MJ Wawer, JM Law, MK Haynes, ... Cell 167 (1), 171-186. e15, 2016 | 436 | 2016 |
| Quantitative production of macrophages or neutrophils ex vivo using conditional Hoxb8 GG Wang, KR Calvo, MP Pasillas, DB Sykes, H Häcker, MP Kamps Nature methods 3 (4), 287-293, 2006 | 405 | 2006 |
| TH2 cytokines and allergic challenge induce Ym1 expression in macrophages by a STAT6-dependent mechanism JS Welch, L Escoubet-Lozach, DB Sykes, K Liddiard, DR Greaves, ... Journal of Biological Chemistry 277 (45), 42821-42829, 2002 | 316 | 2002 |
| SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β‐catenin P Simic, K Zainabadi, E Bell, DB Sykes, B Saez, S Lotinun, R Baron, ... EMBO molecular medicine 5 (3), 430-440, 2013 | 252 | 2013 |
| Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin R Palchaudhuri, B Saez, J Hoggatt, A Schajnovitz, DB Sykes, TA Tate, ... Nature biotechnology 34 (7), 738-745, 2016 | 222 | 2016 |
| Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53 KW Yoon, S Byun, E Kwon, SY Hwang, K Chu, M Hiraki, SH Jo, A Weins, ... Science 349 (6247), 1261669, 2015 | 219 | 2015 |
| The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies S Christian, C Merz, L Evans, S Gradl, H Seidel, A Friberg, A Eheim, ... Leukemia 33 (10), 2403-2415, 2019 | 167 | 2019 |
| Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease E Hahm, C Wei, I Fernandez, J Li, NJ Tardi, M Tracy, S Wadhwani, Y Cao, ... Nature medicine 23 (1), 100-106, 2017 | 154 | 2017 |
| Hoxa9 immortalizes a granulocyte-macrophage colony-stimulating factor-dependent promyelocyte capable of biphenotypic differentiation to neutrophils or macrophages, independent … KR Calvo, DB Sykes, M Pasillas, MP Kamps Molecular and cellular biology 20 (9), 3274-3285, 2000 | 151 | 2000 |
| Nup98-HoxA9 immortalizes myeloid progenitors, enforces expression of Hoxa9, Hoxa7 and Meis1, and alters cytokine-specific responses in a manner similar to that induced by … KR Calvo, DB Sykes, MP Pasillas, MP Kamps Oncogene 21 (27), 4247-4256, 2002 | 146 | 2002 |
| An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation GW Klappacher, VV Lunyak, DB Sykes, D Sawka-Verhelle, J Sage, ... Cell 109 (2), 169-180, 2002 | 127 | 2002 |
| Meis1a suppresses differentiation by G-CSF and promotes proliferation by SCF: potential mechanisms of cooperativity with Hoxa9 in myeloid leukemia KR Calvo, PS Knoepfler, DB Sykes, MP Pasillas, MP Kamps Proceedings of the National Academy of Sciences 98 (23), 13120-13125, 2001 | 120 | 2001 |
| Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment Y Kfoury, N Baryawno, N Severe, S Mei, K Gustafsson, T Hirz, T Brouse, ... Cancer cell 39 (11), 1464-1478. e8, 2021 | 108 | 2021 |
| Induction of a timed metabolic collapse to overcome cancer chemoresistance N Van Gastel, JB Spinelli, A Sharda, A Schajnovitz, N Baryawno, C Rhee, ... Cell Metabolism 32 (3), 391-403. e6, 2020 | 99 | 2020 |
| The emergence of dihydroorotate dehydrogenase (DHODH) as a therapeutic target in acute myeloid leukemia DB Sykes Expert opinion on therapeutic targets 22 (11), 893-898, 2018 | 97 | 2018 |
| The hematopoietic stem cell niche D Park, DB Sykes, DT Scadden Frontiers in bioscience (Landmark edition) 17, 30, 2012 | 94 | 2012 |
| The TEMPI syndrome—a novel multisystem disease DB Sykes, W Schroyens, C O'Connell New England Journal of Medicine 365 (5), 475-477, 2011 | 92 | 2011 |
| Glycerol-3-phosphate is an FGF23 regulator derived from the injured kidney P Simic, W Kim, W Zhou, KA Pierce, W Chang, DB Sykes, NB Aziz, ... The Journal of clinical investigation 130 (3), 1513-1526, 2020 | 88 | 2020 |
| Dectin-1 activation controls maturation of β-1, 3-glucan-containing phagosomes MK Mansour, JM Tam, NS Khan, M Seward, PJ Davids, S Puranam, ... Journal of Biological Chemistry 288 (22), 16043-16054, 2013 | 85 | 2013 |
| Dectin-1 activation controls maturation of β-1, 3-glucan-containing phagosomes MK Mansour, JM Tam, NS Khan, M Seward, PJ Davids, S Puranam, ... Journal of Biological Chemistry 288 (22), 16043-16054, 2013 | 85 | 2013 |
David ScaddenHarvard UniversityVerified email at mgh.harvard.edu
