Patrick T. Gunning
Patrick T. Gunning
Canada Research Chair and Associate Professor of Chemistry
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Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts
X Zhang, P Yue, BDG Page, T Li, W Zhao, AT Namanja, D Paladino, ...
Proceedings of the National Academy of Sciences 109 (24), 9623-9628, 2012
An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects
KAZ Siddiquee, PT Gunning, M Glenn, WP Katt, S Zhang, C Schroeck, ...
ACS chemical biology 2 (12), 787-798, 2007
A novel small-molecule disrupts Stat3 SH2 domain–phosphotyrosine interactions and Stat3-dependent tumor processes
X Zhang, P Yue, S Fletcher, W Zhao, PT Gunning, J Turkson
Biochemical pharmacology 79 (10), 1398-1409, 2010
Advances in covalent kinase inhibitors
A Abdeldayem, YS Raouf, SN Constantinescu, R Moriggl, PT Gunning
Chemical Society Reviews 49 (9), 2617-2687, 2020
Implications of STAT3 and STAT5 signaling on gene regulation and chromatin remodeling in hematopoietic cancer
B Wingelhofer, HA Neubauer, P Valent, X Han, SN Constantinescu, ...
Leukemia 32 (8), 1713-1726, 2018
Recent advances in biosensory and medicinal therapeutic applications of zinc (II) and copper (II) coordination complexes
JA Drewry, PT Gunning
Coordination Chemistry Reviews 255 (3-4), 459-472, 2011
STAT5 is a key regulator in NK cells and acts as a molecular switch from tumor surveillance to tumor promotion
D Gotthardt, EM Putz, E Grundschober, M Prchal-Murphy, E Straka, ...
Cancer Discovery 6 (4), 414-429, 2016
Combined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapy-resistant chronic myeloid leukemia
AM Eiring, BDG Page, IL Kraft, CC Mason, NA Vellore, D Resetca, ...
Leukemia 29 (3), 586-597, 2015
Pharmacologic inhibition of STAT5 in acute myeloid leukemia
B Wingelhofer, B Maurer, EC Heyes, AA Cumaraswamy, A Berger-Becvar, ...
Leukemia 32 (5), 1135-1146, 2018
Molecular approaches towards the inhibition of the signal transducer and activator of transcription 3 (Stat3) protein
S Fletcher, J Turkson, PT Gunning
ChemMedChem 3 (8), 1159, 2008
Progress towards the development of SH2 domain inhibitors
D Kraskouskaya, E Duodu, CC Arpin, PT Gunning
Chemical Society reviews 42 (8), 3337-3370, 2013
Signal transducer and activator of transcription 3 inhibitors: a patent review
BDG Page, DP Ball, PT Gunning
Expert opinion on therapeutic patents 21 (1), 65-83, 2011
Molecular disruption of oncogenic signal transducer and activator of transcription 3 (STAT3) protein
S Fletcher, JA Drewry, VM Shahani, BDG Page, PT Gunning
Biochemistry and Cell Biology 87 (6), 825-833, 2009
Potent targeting of the STAT3 protein in brain cancer stem cells: a promising route for treating glioblastoma
S Haftchenary, HA Luchman, AO Jouk, AJ Veloso, BDG Page, XR Cheng, ...
ACS medicinal chemistry letters 4 (11), 1102-1107, 2013
Disruption of transcriptionally active Stat3 dimers with non-phosphorylated, salicylic acid-based small molecules: potent in vitro and tumor cell activities
S Fletcher, J Singh, X Zhang, P Yue, BDG Page, S Sharmeen, ...
Chembiochem: a European journal of chemical biology 10 (12), 1959, 2009
Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity
BDG Page, H Khoury, RC Laister, S Fletcher, M Vellozo, A Manzoli, P Yue, ...
Journal of medicinal chemistry 55 (3), 1047-1055, 2012
Signal transducer and activator of transcription 3 and 5 regulate system Xc-and redox balance in human breast cancer cells
K Linher-Melville, S Haftchenary, P Gunning, G Singh
Molecular and cellular biochemistry 405, 205-221, 2015
Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: structural recognition of STAT SH2 domains
PT Gunning, WP Katt, M Glenn, K Siddique, JS Kim, R Jove, SM Sebti, ...
Bioorganic & medicinal chemistry letters 17 (7), 1875-1878, 2007
Inhibiting aberrant Stat3 function with molecular therapeutics: a progress report
S Haftchenary, M Avadisian, PT Gunning
Anti-cancer drugs 22 (2), 115-127, 2011
Direct targeting options for STAT3 and STAT5 in cancer
A Orlova, C Wagner, ED de Araujo, D Bajusz, HA Neubauer, M Herling, ...
Cancers 11 (12), 1930, 2019
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