| Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice R Deprez-Poulain, N Hennuyer, D Bosc, WG Liang, E Enée, X Marechal, ... Nature communications 6 (1), 8250, 2015 | 96 | 2015 |
| Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3 WG Liang, CG Triandafillou, TY Huang, MML Zulueta, S Banerjee, ... Proceedings of the National Academy of Sciences 113 (18), 5000-5005, 2016 | 82 | 2016 |
| Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme LA McCord, WG Liang, E Dowdell, V Kalas, RJ Hoey, A Koide, S Koide, ... Proceedings of the National Academy of Sciences 110 (34), 13827-13832, 2013 | 70 | 2013 |
| Molecular basis of substrate recognition and degradation by human presequence protease JV King, WG Liang, KP Scherpelz, AB Schilling, SC Meredith, WJ Tang Structure 22 (7), 996-1007, 2014 | 55 | 2014 |
| Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme Z Zhang, WG Liang, LJ Bailey, YZ Tan, H Wei, A Wang, M Farcasanu, ... Elife 7, e33572, 2018 | 53 | 2018 |
| In vivo epidermal migration requires focal adhesion targeting of ACF7 J Yue, Y Zhang, WG Liang, X Gou, P Lee, H Liu, W Lyu, WJ Tang, ... Nature communications 7 (1), 11692, 2016 | 53 | 2016 |
| Locking the elbow: Improved antibody Fab fragments as chaperones for structure determination LJ Bailey, KM Sheehy, PK Dominik, WG Liang, H Rui, M Clark, ... Journal of molecular biology 430 (3), 337-347, 2018 | 46 | 2018 |
| Conversion of D-ribulose 5-phosphate to D-xylulose 5-phosphate: new insights from structural and biochemical studies on human RPE W Liang, S Ouyang, N Shaw, A Joachimiak, R Zhang, ZJ Liu The FASEB Journal 25 (2), 497, 2011 | 42 | 2011 |
| Degradation of Alzheimer’s amyloid-β by a catalytically inactive insulin-degrading enzyme BR Sahoo, PK Panda, W Liang, WJ Tang, R Ahuja, A Ramamoorthy Journal of molecular biology 433 (13), 166993, 2021 | 31 | 2021 |
| ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics Y Ma, J Yue, Y Zhang, C Shi, M Odenwald, WG Liang, Q Wei, A Goel, ... Nature communications 8 (1), 15375, 2017 | 31 | 2017 |
| Structure–activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino] acetic acids, dual binders of human insulin-degrading enzyme J Charton, M Gauriot, J Totobenazara, N Hennuyer, J Dumont, D Bosc, ... European journal of medicinal chemistry 90, 547-567, 2015 | 31 | 2015 |
| Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme WG Liang, M Ren, F Zhao, WJ Tang Journal of molecular biology 427 (6), 1345-1358, 2015 | 30 | 2015 |
| Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus S Ouyang, B Gong, JZ Li, LX Zhao, W Wu, FS Zhang, L Sun, SJ Wang, ... Journal of molecular medicine 90, 837-846, 2012 | 28 | 2012 |
| S-SAD phasing study of death receptor 6 and its solution conformation revealed by SAXS H Ru, L Zhao, W Ding, L Jiao, N Shaw, W Liang, L Zhang, LW Hung, ... Acta Crystallographica Section D: Biological Crystallography 68 (5), 521-530, 2012 | 25 | 2012 |
| Identification of ebselen as a potent inhibitor of insulin degrading enzyme by a drug repurposing screening F Leroux, D Bosc, T Beghyn, P Hermant, S Warenghem, V Landry, ... European journal of medicinal chemistry 179, 557-566, 2019 | 15 | 2019 |
| Structural and functional characterization of the C-terminal catalytic domain of SSV1 integrase Z Zhan, S Ouyang, W Liang, Z Zhang, ZJ Liu, L Huang Acta Crystallographica Section D: Biological Crystallography 68 (6), 659-670, 2012 | 15 | 2012 |
| Reinvestigating the synthesis and efficacy of small benzimidazole derivatives as presequence protease enhancers NS Li, W Liang, JA Piccirilli, WJ Tang European journal of medicinal chemistry 184, 111746, 2019 | 8 | 2019 |
| Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition WG Liang, J Wijaya, H Wei, AJ Noble, JM Mancl, S Mo, D Lee, JV Lin King, ... Nature communications 13 (1), 1833, 2022 | 6 | 2022 |
| Structural analysis of Mycobacterium tuberculosis M13 metalloprotease Zmp1 open states WG Liang, JM Mancl, M Zhao, WJ Tang Structure 29 (7), 709-720. e3, 2021 | 5 | 2021 |
| Crystallization, preliminary X-ray crystallographic and cryo-electron microscopy analysis of a bifunctional enzyme fucokinase/l-fucose-1-P-guanylyltransferase from Bacteroides … C Cheng, J Gu, J Su, W Ding, J Yin, W Liang, X Yu, J Ma, PG Wang, ... Acta Crystallographica Section F: Structural Biology Communications 70 (9 …, 2014 | 2 | 2014 |
Wei-Jen TangUniversity of ChicagoVerified email at bsd.uchicago.edu
