Nicolai Juul Birkbak

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Charles SwantonFrancis Crick InstituteVerified email at crick.ac.uk
Zoltan SzallasiHarvard Medical SchoolVerified email at childrens.harvard.edu
Aron Charles EklundClinical Microbiomics A/SVerified email at clinical-microbiomics.com
Nicholas McGranahanGroup Leader, CRUK Lung Cancer Centre of Excellence, UCL Cancer InstituteVerified email at ucl.ac.uk
Andrea L RichardsonAssociate Professor of Pathology and Oncology, Johns Hopkins University School of MedicineVerified email at jhmi.edu
Hugo AertsDirector AI in Medicine (AIM) @ Harvard-MGB | Professor @ MaastrichtUVerified email at dfci.harvard.edu
Qiyuan LiSchool of Medicine, Xiamen UniversityVerified email at xmu.edu.cn
Andrew J RowanPrincipal Laboratory Research Scientist, Francis Crick InstituteVerified email at crick.ac.uk
Benjamin Haibe-KainsScientist (Principal Investigator), Princess Margaret Cancer Centre, University Health NetworkVerified email at uhnresearch.ca
John QuackenbushHarvard T.H. Chan School of Public Health, Channing Division of Network Medicine, and Dana-FarberVerified email at hsph.harvard.edu
Francesco FaveroCopenhagen UniversityVerified email at bric.ku.dk
Chris AbboshAstraZenecaVerified email at astrazeneca.com
Andrew H. BeckCo-Founder and CEO at PathAIVerified email at PathAI.com
Marcin KrzystanekAssistant Professor, Technical University of DenmarkVerified email at cbs.dtu.dk
Mariam Jamal-HanjaniUCL Cancer InstituteVerified email at doctors.org.uk
Andrea Marion MarquardPostdoc, Technical University of DenmarkVerified email at dtu.dk
Gareth WilsonFrancis Crick Institute, UCL Cancer InstituteVerified email at crick.ac.uk
Rebecca A BurrellUniversity of CambridgeVerified email at cruk.cam.ac.uk
Prof Marco GerlingerBarts Cancer Institute, London, UKVerified email at qmul.ac.uk
Kevin LITCHFIELDResearch Leader - Isomorphic Labs (Alphabet company), Honorary Group Leader - UCLVerified email at google.com

Nicolai Juul Birkbak

Professor, Department of Molecular Medicine (MOMA), Aarhus University

Verified email at clin.au.dk - Homepage

Cancer Immunology Bioinformatics Intratumor heterogeneity


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Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade N McGranahan, AJS Furness, R Rosenthal, S Ramskov, R Lyngaa, ... Science 351 (6280), 1463-1469, 2016	3074	2016
Tracking the evolution of non–small-cell lung cancer M Jamal-Hanjani, GA Wilson, N McGranahan, NJ Birkbak, TBK Watkins, ... New England Journal of Medicine 376 (22), 2109-2121, 2017	2279	2017
Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution C Abbosh, NJ Birkbak, GA Wilson, M Jamal-Hanjani, T Constantin, ... Nature 545 (7655), 446-451, 2017	1778	2017
Artificial intelligence in cancer imaging: clinical challenges and applications WL Bi, A Hosny, MB Schabath, ML Giger, NJ Birkbak, A Mehrtash, ... CA: a cancer journal for clinicians 69 (2), 127-157, 2019	1480	2019
Chromosomal instability drives metastasis through a cytosolic DNA response SF Bakhoum, B Ngo, AM Laughney, JA Cavallo, CJ Murphy, P Ly, P Shah, ... Nature 553 (7689), 467-472, 2018	1302	2018
Efficacy of neoadjuvant Cisplatin in triple-negative breast cancer DP Silver, AL Richardson, AC Eklund, ZC Wang, Z Szallasi, Q Li, N Juul, ... Journal of clinical oncology 28 (7), 1145-1153, 2010	1274	2010
Allele-specific HLA loss and immune escape in lung cancer evolution N McGranahan, R Rosenthal, CT Hiley, AJ Rowan, TBK Watkins, ... Cell 171 (6), 1259-1271. e11, 2017	1232	2017
Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis S Turajlic, K Litchfield, H Xu, R Rosenthal, N McGranahan, JL Reading, ... The lancet oncology 18 (8), 1009-1021, 2017	903	2017
Neoantigen-directed immune escape in lung cancer evolution R Rosenthal, EL Cadieux, R Salgado, MA Bakir, DA Moore, CT Hiley, ... Nature 567 (7749), 479-485, 2019	778	2019
Clonal status of actionable driver events and the timing of mutational processes in cancer evolution N McGranahan, F Favero, EC De Bruin, NJ Birkbak, Z Szallasi, ... Science translational medicine 7 (283), 283ra54-283ra54, 2015	728	2015
Sequenza: allele-specific copy number and mutation profiles from tumor sequencing data F Favero, T Joshi, AM Marquard, NJ Birkbak, M Krzystanek, Q Li, ... Annals of Oncology 26 (1), 64-70, 2015	716	2015
Deterministic evolutionary trajectories influence primary tumor growth: TRACERx renal S Turajlic, H Xu, K Litchfield, A Rowan, S Horswell, T Chambers, ... Cell 173 (3), 595-610. e11, 2018	583	2018
Inconsistency in large pharmacogenomic studies B Haibe-Kains, N El-Hachem, NJ Birkbak, AC Jin, AH Beck, HJWL Aerts, ... Nature 504 (7480), 389-393, 2013	573	2013
Telomeric allelic imbalance indicates defective DNA repair and sensitivity to DNA-damaging agents NJ Birkbak, ZC Wang, JY Kim, AC Eklund, Q Li, R Tian, C Bowman-Colin, ... Cancer discovery 2 (4), 366-375, 2012	573	2012
Fc effector function contributes to the activity of human anti-CTLA-4 antibodies FA Vargas, AJS Furness, K Litchfield, K Joshi, R Rosenthal, E Ghorani, ... Cancer cell 33 (4), 649-663. e4, 2018	566	2018
MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling SJ Song, L Poliseno, MS Song, U Ala, K Webster, C Ng, G Beringer, ... Cell 154 (2), 311-324, 2013	530	2013
Chromosomal instability confers intrinsic multidrug resistance AJX Lee, D Endesfelder, AJ Rowan, A Walther, NJ Birkbak, PA Futreal, ... Cancer research 71 (5), 1858-1870, 2011	529	2011
Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers CM Blakely, TBK Watkins, W Wu, B Gini, JJ Chabon, CE McCoach, ... Nature genetics 49 (12), 1693-1704, 2017	500	2017
Predicting response to cancer immunotherapy using noninvasive radiomic biomarkers S Trebeschi, SG Drago, NJ Birkbak, I Kurilova, AM Cǎlin, AD Pizzi, ... Annals of Oncology 30 (6), 998-1004, 2019	468	2019
Fc-optimized anti-CD25 depletes tumor-infiltrating regulatory T cells and synergizes with PD-1 blockade to eradicate established tumors FA Vargas, AJS Furness, I Solomon, K Joshi, L Mekkaoui, MH Lesko, ... Immunity 46 (4), 577-586, 2017	431	2017

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