Adrien Leger
Adrien Leger
Verified email at ebi.ac.uk
TitleCited byYear
Advanced characterization of DNA molecules in rAAV vector preparations by single-stranded virus next-generation sequencing
E Lecomte, B Tournaire, B Cogné, JB Dupont, P Lindenbaum, ...
Molecular Therapy-Nucleic Acids 4, e260, 2015
312015
Accurate identification and quantification of DNA species by next-generation sequencing in adeno-associated viral vectors produced in insect cells
M Penaud-Budloo, E Lecomte, A Guy-Duché, S Saleun, A Roulet, ...
Human gene therapy methods 28 (3), 148-162, 2017
152017
Short-lived recombinant adeno-associated virus transgene expression in dystrophic muscle is associated with oxidative damage to transgene mRNA
JB Dupont, B Tournaire, C Georger, B Marolleau, L Jeanson-Leh, ...
Molecular Therapy-Methods & Clinical Development 2, 15010, 2015
142015
Adeno-associated viral vector-mediated transgene expression is independent of DNA methylation in primate liver and skeletal muscle
A Léger, C Le Guiner, ML Nickerson, KMG Im, N Ferry, P Moullier, ...
PloS one 6 (6), 2011
142011
NGS library preparation may generate artifactual integration sites of AAV vectors
B Cogne, R Snyder, P Lindenbaum, JB Dupont, R Redon, P Moullier, ...
Nature medicine 20 (6), 577, 2014
92014
Identification of miRNAs involved in reprogramming acinar cells into insulin producing cells
J Teichenne, M Morró, A Casellas, V Jimenez, N Tellez, A Leger, F Bosch, ...
PloS one 10 (12), 2015
82015
pycoQC, interactive quality control for Oxford Nanopore Sequencing
A Leger, T Leonardi
Journal of Open Source Software 4 (34), 1236, 2019
22019
RNA modifications detection by comparative Nanopore direct RNA sequencing
A Leger, PP Amaral, L Pandolfini, C Capitanchik, F Capraro, I Barbieri, ...
BioRxiv, 843136, 2019
22019
Single-stranded DNA virus sequencing (SSV-Seq) for characterization of residual DNA and AAV vector genomes
E Lecomte, A Leger, M Penaud-Budloo, E Ayuso
Adeno-Associated Virus Vectors, 85-106, 2019
22019
Genetics instability of wtAAV2 genome and AAV promoter activities in the Baculovirus/Sf9 cells system
A Savy, MU Kaikkonen, A Léger, Y Dickx, L Galibert, OW Merten
PloS one 13 (7), 2018
12018
RNA-Seq Analysis of an Antisense Sequence Optimized for Exon Skipping in Duchenne Patients Reveals No Off-Target Effect
C Domenger, M Allais, V François, A Léger, E Lecomte, M Montus, ...
Molecular Therapy-Nucleic Acids 10, 277-291, 2018
2018
Impact d’un traitement antioxydant sur le transfert de gène par un vecteur AAVr dans un modèle murin de la dystrophie musculaire de Duchenne
JB Dupont, B Tournaire, R Durand, B Marolleau, É Bertil, C Georger, ...
Les Cahiers de Myologie, 99-101, 2016
2016
390. Impact of a Treatment with Antioxidant on Gene Transfer Efficiency After Recombinant Adeno-Associated Vector Injection in a Mouse Model of Duchenne Muscular Dystrophy
JB Dupont, B Tournaire, R Durand, B Marolleau, E Bertil, C Georger, ...
Molecular Therapy 24, S155, 2016
2016
Exhaustive characterization of DNA contaminants in rAAV productions by next generation sequencing
B Cogne, E Lecomte, B Tournaire, M Martin-Fontaine, F Broucque, ...
HUMAN GENE THERAPY 25 (11), A54-A54, 2014
2014
ESGCT and NVGCT Collaborative Congress: The Hague-23 to 26 October Abstracts
E Vroom, A Aartsma-Rus, RC Hoeben, H Büning, H Abken, M Pegtel, ...
Human Gene Therapy 25 (11), A1-A121, 2014
2014
Insight into molecular events associated with partial restriction of Adeno-Associated Vector genome expression in dystrophic muscles
JB Dupont, B Tournaire, L Jeanson-Leh, L Dubreil, C Georger, ...
HUMAN GENE THERAPY 24 (12), A40-A40, 2013
2013
76. Epigenetic Alterations in the Dystrophic Muscle Environment Down-Regulate rAAV-Mediated Transgene Expression
JB Dupont, B Tournaire, C Georger, L Van Wittenberghe, B Marolleau, ...
Molecular Therapy 21, 1, 2013
2013
The Murine Dystrophic Muscle Environment Reduces Adeno-Associated Virus Vector-mediated Transgene Expression
JB Dupont, A Leger, M Penaud-Budloo, E Bertil, C Georger, R Snyder, ...
HUMAN GENE THERAPY 23 (10), A130-A130, 2012
2012
Pharmacologie moléculaire des vecteurs adéno-associés in situ dans le muscle squelettique: implications de la régulation épigénétique endogène sur l'expression du génome …
A Léger
Nantes, 2012
2012
Adeno-Associated Viral Vector DNA is insensitive to de novo CpG methylation but rapidly associated with histone modifications in liver and skeletal muscle
A Leger, C Le Guiner, ML Nickerson, N Ferry, P Moullier, RO Snyder, ...
HUMAN GENE THERAPY 22 (10), A103-A103, 2011
2011
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