Darragh Duffy
Darragh Duffy
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Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients
J Hadjadj, N Yatim, L Barnabei, A Corneau, J Boussier, N Smith, H Péré, ...
Science 369 (6504), 718-724, 2020
Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients
J Hadjadj, N Yatim, L Barnabei, A Corneau, J Boussier, N Smith, H Péré, ...
Science 369 (6504), 718-724, 2020
Auto-antibodies against type I IFNs in patients with life-threatening COVID-19
P Bastard, LB Rosen, Q Zhang, E Michailidis, HH Hoffmann, Y Zhang, ...
Science, 2020
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
Q Zhang, P Bastard, Z Liu, J Le Pen, M Moncada-Velez, J Chen, M Ogishi, ...
Science, 2020
Mitochondrial double-stranded RNA triggers antiviral signalling in humans
A Dhir, S Dhir, LS Borowski, L Jimenez, M Teitell, A Rötig, YJ Crow, ...
Nature 560 (7717), 238-242, 2018
Autoantibodies neutralizing type I IFNs are present in~ 4% of uninfected individuals over 70 years old and account for~ 20% of COVID-19 deaths
P Bastard, A Gervais, T Le Voyer, J Rosain, Q Philippot, J Manry, ...
Science Immunology 6 (62), 2021
Genetic adaptation and Neandertal admixture shaped the immune system of human populations
H Quach, M Rotival, J Pothlichet, YHE Loh, M Dannemann, N Zidane, ...
Cell 167 (3), 643-656. e17, 2016
Detection of interferon alpha protein reveals differential levels and cellular sources in disease
MP Rodero, J Decalf, V Bondet, D Hunt, GI Rice, S Werneke, ...
Journal of Experimental Medicine 214 (5), 1547-1555, 2017
Angiopoietin-2 as a marker of endothelial activation is a good predictor factor for intensive care unit admission of COVID-19 patients
DM Smadja, CL Guerin, R Chocron, N Yatim, J Boussier, N Gendron, ...
Angiogenesis, 1-10, 2020
Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors
E Patin, M Hasan, J Bergstedt, V Rouilly, V Libri, A Urrutia, C Alanio, ...
Nature immunology 19 (3), 302-314, 2018
Functional analysis via standardized whole-blood stimulation systems defines the boundaries of a healthy immune response to complex stimuli
D Duffy, V Rouilly, V Libri, M Hasan, B Beitz, M David, A Urrutia, A Bisiaux, ...
Immunity 40 (3), 436-450, 2014
Efficacy of the Janus kinase 1/2 inhibitor ruxolitinib in the treatment of vasculopathy associated with TMEM173-activating mutations in 3 children
ML Frémond, MP Rodero, N Jeremiah, A Belot, E Jeziorski, D Duffy, ...
Journal of Allergy and Clinical Immunology 138 (6), 1752-1755, 2016
Neutrophils transport antigen from the dermis to the bone marrow, initiating a source of memory CD8+ T cells
D Duffy, H Perrin, V Abadie, N Benhabiles, A Boissonnas, C Liard, ...
Immunity 37 (5), 917-929, 2012
Type I interferon-mediated autoinflammation due to DNase II deficiency
MP Rodero, A Tesser, E Bartok, GI Rice, E Della Mina, M Depp, B Beitz, ...
Nature communications 8 (1), 2176, 2017
Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges
B Piasecka, D Duffy, A Urrutia, H Quach, E Patin, C Posseme, J Bergstedt, ...
Proceedings of the National Academy of Sciences 115 (3), E488-E497, 2018
JAK inhibitor improves type I interferon induced damage: proof of concept in dermatomyositis
L Ladislau, X Suárez-Calvet, S Toquet, O Landon-Cardinal, D Amelin, ...
Brain 141 (6), 1609-1621, 2018
CD56brightCD16+ NK cells: a functional intermediate stage of NK cell differentiation
V Béziat, D Duffy, SN Quoc, M Le Garff-Tavernier, J Decocq, ...
The Journal of Immunology 186 (12), 6753-6761, 2011
Nanoparticle-based targeting of vaccine compounds to skin antigen-presenting cells by hair follicles and their transport in mice
B Mahe, A Vogt, C Liard, D Duffy, V Abadie, O Bonduelle, A Boissonnas, ...
Journal of Investigative Dermatology 129 (5), 1156-1164, 2009
SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance
R Robinot, M Hubert, G Dias De Melo, F Lazarini, T Bruel, N Smith, ...
Virologie, S32-S33, 2021
Inhibition of the dipeptidyl peptidase DPP4 (CD26) reveals IL-33-dependent eosinophil-mediated control of tumor growth
C Hollande, J Boussier, J Ziai, T Nozawa, V Bondet, W Phung, B Lu, ...
Nature immunology 20 (3), 257-264, 2019
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