Graham Simmons
Graham Simmons
Senior Investigator, Vitalant Research Institute
Verified email at
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Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry
G Simmons, DN Gosalia, AJ Rennekamp, JD Reeves, SL Diamond, ...
Proceedings of the National Academy of Sciences 102 (33), 11876-11881, 2005
Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist
G Simmons, PR Clapham, L Picard, RE Offord, MM Rosenkilde, ...
Science 276 (5310), 276-279, 1997
Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entry
G Simmons, JD Reeves, AJ Rennekamp, SM Amberg, AJ Piefer, P Bates
Proceedings of the National Academy of Sciences 101 (12), 4240-4245, 2004
A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus
TN Kledal, MM Rosenkilde, F Coulin, G Simmons, AH Johnsen, S Alouani, ...
Science 277 (5332), 1656-1659, 1997
Protease inhibitors targeting coronavirus and filovirus entry
Y Zhou, P Vedantham, K Lu, J Agudelo, R Carrion Jr, JW Nunneley, ...
Antiviral research 116, 76-84, 2015
Aminooxypentane-RANTES induces CCR5 internalization but inhibits recycling: a novel inhibitory mechanism of HIV infectivity
M Mack, B Luckow, PJ Nelson, J Cihak, G Simmons, PR Clapham, ...
The Journal of experimental medicine 187 (8), 1215-1224, 1998
Primary, syncytium-inducing human immunodeficiency virus type 1 isolates are dual-tropic and most can use either Lestr or CCR5 as coreceptors for virus entry
G Simmons, D Wilkinson, JD Reeves, MT Dittmar, S Beddows, J Weber, ...
Journal of virology 70 (12), 8355-8360, 1996
DC-SIGN and DC-SIGNR interact with the glycoprotein of Marburg virus and the S protein of severe acute respiratory syndrome coronavirus
A Marzi, T Gramberg, G Simmons, P Möller, AJ Rennekamp, ...
Journal of virology 78 (21), 12090-12095, 2004
DC-SIGN and DC-SIGNR bind ebola glycoproteins and enhance infection of macrophages and endothelial cells
G Simmons, JD Reeves, CC Grogan, LH Vandenberghe, F Baribaud, ...
Virology 305 (1), 115-123, 2003
Differential downregulation of ACE2 by the spike proteins of severe acute respiratory syndrome coronavirus and human coronavirus NL63
I Glowacka, S Bertram, P Herzog, S Pfefferle, I Steffen, MO Muench, ...
Journal of virology 84 (2), 1198-1205, 2010
Proteolytic activation of the SARS-coronavirus spike protein: cutting enzymes at the cutting edge of antiviral research
G Simmons, P Zmora, S Gierer, A Heurich, S Pöhlmann
Antiviral research 100 (3), 605-614, 2013
The spike protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2, and is targeted by neutralizing antibodies
S Gierer, S Bertram, F Kaup, F Wrensch, A Heurich, A Krämer-Kühl, ...
Journal of virology 87 (10), 5502-5511, 2013
Cleavage and activation of the severe acute respiratory syndrome coronavirus spike protein by human airway trypsin-like protease
S Bertram, I Glowacka, MA Müller, H Lavender, K Gnirss, I Nehlmeier, ...
Journal of virology 85 (24), 13363-13372, 2011
Differential N-linked glycosylation of human immunodeficiency virus and Ebola virus envelope glycoproteins modulates interactions with DC-SIGN and DC-SIGNR
G Lin, G Simmons, S Pöhlmann, F Baribaud, H Ni, GJ Leslie, ...
Journal of virology 77 (2), 1337-1346, 2003
KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells
JT Stine, C Wood, M Hill, A Epp, CJ Raport, VL Schweickart, Y Endo, ...
Blood, The Journal of the American Society of Hematology 95 (4), 1151-1157, 2000
Ebola virus glycoproteins induce global surface protein down-modulation and loss of cell adherence
G Simmons, RJ Wool-Lewis, F Baribaud, RC Netter, P Bates
Journal of virology 76 (5), 2518-2528, 2002
A small molecule antagonist of chemokine receptors CCR1 and CCR3: potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry
I Sabroe, MJ Peck, BJ Van Keulen, A Jorritsma, G Simmons, PR Clapham, ...
Journal of Biological Chemistry 275 (34), 25985-25992, 2000
Inhibition of human immunodeficiency virus fusion by a monoclonal antibody to a coreceptor (CXCR4) is both cell type and virus strain dependent
A McKnight, D Wilkinson, G Simmons, S Talbot, L Picard, M Ahuja, ...
Journal of Virology 71 (2), 1692-1696, 1997
Biological analysis of human immunodeficiency virus type 1 R5 envelopes amplified from brain and lymph node tissues of AIDS patients with neuropathology reveals two distinct …
PJ Peters, J Bhattacharya, S Hibbitts, MT Dittmar, G Simmons, J Bell, ...
Journal of virology 78 (13), 6915-6926, 2004
A novel rhabdovirus associated with acute hemorrhagic fever in central Africa
G Grard, JN Fair, D Lee, E Slikas, I Steffen, JJ Muyembe, T Sittler, ...
Public Library of Science 8 (9), e1002924, 2012
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