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Alice Giustacchini
Alice Giustacchini
University College London - Email: a.giustacchini@ucl.ac.uk
Verificeret mail på ucl.ac.uk
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Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia
A Giustacchini, S Thongjuea, N Barkas, PS Woll, BJ Povinelli, CAG Booth, ...
Nature medicine 23 (6), 692-702, 2017
3972017
Stable knockdown of microRNA in vivo by lentiviral vectors
B Gentner, G Schira, A Giustacchini, M Amendola, BD Brown, M Ponzoni, ...
Nature methods 6 (1), 63-66, 2009
3812009
Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo
PS Woll, U Kjällquist, O Chowdhury, H Doolittle, DC Wedge, S Thongjuea, ...
Cancer cell 25 (6), 794-808, 2014
3562014
Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo
PS Woll, U Kjällquist, O Chowdhury, H Doolittle, DC Wedge, S Thongjuea, ...
Cancer cell 25 (6), 794-808, 2014
3562014
Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells
A Grover, A Sanjuan-Pla, S Thongjuea, J Carrelha, A Giustacchini, ...
Nature communications 7 (1), 11075, 2016
2942016
Unravelling intratumoral heterogeneity through high-sensitivity single-cell mutational analysis and parallel RNA sequencing
A Rodriguez-Meira, G Buck, SA Clark, BJ Povinelli, V Alcolea, E Louka, ...
Molecular cell 73 (6), 1292-1305. e8, 2019
2452019
Distinct myeloid progenitor–differentiation pathways identified through single-cell RNA sequencing
R Drissen, N Buza-Vidas, P Woll, S Thongjuea, A Gambardella, ...
Nature immunology 17 (6), 666-676, 2016
2392016
Attenuation of miR-126 activity expands HSC in vivo without exhaustion
ER Lechman, B Gentner, P van Galen, A Giustacchini, M Saini, ...
Cell stem cell 11 (6), 799-811, 2012
2322012
Identification of hematopoietic stem cell–specific miRNAs enables gene therapy of globoid cell leukodystrophy
B Gentner, I Visigalli, H Hiramatsu, E Lechman, S Ungari, A Giustacchini, ...
Science translational medicine 2 (58), 58ra84-58ra84, 2010
2242010
Systemic and targeted delivery of semaphorin 3A inhibits tumor angiogenesis and progression in mouse tumor models
A Casazza, X Fu, I Johansson, L Capparuccia, F Andersson, ...
Arteriosclerosis, thrombosis, and vascular biology 31 (4), 741-749, 2011
1432011
Assessing similarity to primary tissue and cortical layer identity in induced pluripotent stem cell-derived cortical neurons through single-cell transcriptomics
AE Handel, S Chintawar, T Lalic, E Whiteley, J Vowles, A Giustacchini, ...
Human molecular genetics 25 (5), 989-1000, 2016
1102016
A dynamic niche provides Kit ligand in a stage-specific manner to the earliest thymocyte progenitors
M Buono, R Facchini, S Matsuoka, S Thongjuea, D Waithe, TC Luis, ...
Nature cell biology 18 (2), 157-167, 2016
742016
miRNA-126 orchestrates an oncogenic program in B cell precursor acute lymphoblastic leukemia
S Nucera, A Giustacchini, F Boccalatte, A Calabria, C Fanciullo, T Plati, ...
Cancer cell 29 (6), 905-921, 2016
692016
Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors
TC Luis, S Luc, T Mizukami, H Boukarabila, S Thongjuea, PS Woll, ...
Nature immunology 17 (12), 1424-1435, 2016
642016
Ezh2 and Runx1 mutations collaborate to initiate lympho-myeloid leukemia in early thymic progenitors
CAG Booth, N Barkas, WH Neo, H Boukarabila, EJ Soilleux, ...
Cancer Cell 33 (2), 274-291. e8, 2018
582018
Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD–induced myeloproliferation
AJ Mead, WH Neo, N Barkas, S Matsuoka, A Giustacchini, R Facchini, ...
Journal of Experimental Medicine 214 (7), 2005-2021, 2017
542017
A double-switch vector system positively regulates transgene expression by endogenous microRNA expression (miR-ON vector)
M Amendola, A Giustacchini, B Gentner, L Naldini
Molecular Therapy 21 (5), 934-946, 2013
342013
Mbd3/NuRD controls lymphoid cell fate and inhibits tumorigenesis by repressing a B cell transcriptional program
SJ Loughran, F Comoglio, FK Hamey, A Giustacchini, Y Errami, E Earp, ...
Journal of Experimental Medicine 214 (10), 3085-3104, 2017
232017
Driving CAR T stem cell targeting in acute myeloid leukemia: The roads to success
IM Michelozzi, E Kirtsios, A Giustacchini
Cancers 13 (11), 2816, 2021
132021
Activation priming and cytokine polyfunctionality modulate the enhanced functionality of low-affinity CD19 CAR T cells
IM Michelozzi, E Gomez-Castaneda, RVC Pohle, F Cardoso Rodriguez, ...
Blood Advances 7 (9), 1725-1738, 2023
92023
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