| Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription MP Coghlan, AA Culbert, DAE Cross, SL Corcoran, JW Yates, NJ Pearce, ... Chemistry & biology 7 (10), 793-803, 2000 | 1125 | 2000 |
| Inhibition of GSK-3 selectively reduces glucose-6-phosphatase and phosphoenolpyruvate carboxykinase gene expression PA Lochhead, M Coghlan, SQJ Rice, C Sutherland Diabetes 50 (5), 937-946, 2001 | 306 | 2001 |
| c-Jun is a JNK-independent coactivator of the PU. 1 transcription factor G Behre, AJ Whitmarsh, MP Coghlan, T Hoang, CL Carpenter, DE Zhang, ... Journal of Biological Chemistry 274 (8), 4939-4946, 1999 | 243 | 1999 |
| How may GIP enhance the therapeutic efficacy of GLP-1? RJ Samms, MP Coghlan, KW Sloop Trends in Endocrinology & Metabolism 31 (6), 410-421, 2020 | 224 | 2020 |
| Robust anti‐obesity and metabolic effects of a dual GLP‐1/glucagon receptor peptide agonist in rodents and non‐human primates SJ Henderson, A Konkar, DC Hornigold, JL Trevaskis, R Jackson, ... Diabetes, Obesity and Metabolism 18 (12), 1176-1190, 2016 | 222 | 2016 |
| Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist FS Willard, JD Douros, MBN Gabe, AD Showalter, DB Wainscott, ... JCI insight 5 (17), 2020 | 220 | 2020 |
| Stimulation of hepatocyte glucose metabolism by novel small molecule glucokinase activators KJ Brocklehurst, VA Payne, RA Davies, D Carroll, HL Vertigan, ... Diabetes 53 (3), 535-541, 2004 | 188 | 2004 |
| Glucokinase activators in diabetes management M Coghlan, B Leighton Expert opinion on investigational drugs 17 (2), 145-167, 2008 | 144 | 2008 |
| Development of glucose intolerance in male transgenic mice overexpressing human glycogen synthase kinase-3β on a muscle-specific promoter NJ Pearce, JRS Arch, JC Clapham, MP Coghlan, SL Corcoran, CA Lister, ... Metabolism 53 (10), 1322-1330, 2004 | 130 | 2004 |
| Atypical protein kinases Cλ and-ζ associate with the GTP-binding protein Cdc42 and mediate stress fiber loss MP Coghlan, MM Chou, CL Carpenter Molecular and cellular biology 20 (8), 2880-2889, 2000 | 111 | 2000 |
| Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells ML Watson, M Coghlan, HS Hundal Biochemical Journal 417 (3), 791-801, 2009 | 107 | 2009 |
| Predictive blood glucose lowering efficacy by glucokinase activators in high fat fed female Zucker rats GJ Coope, AM Atkinson, C Allott, D McKerrecher, C Johnstone, KG Pike, ... British journal of pharmacology 149 (3), 328-335, 2006 | 96 | 2006 |
| Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist T Kawai, B Sun, H Yoshino, D Feng, Y Suzuki, M Fukazawa, S Nagao, ... Proceedings of the National Academy of Sciences 117 (47), 29959-29967, 2020 | 90 | 2020 |
| GIPR agonism mediates weight-independent insulin sensitization by tirzepatide in obese mice RJ Samms, ME Christe, KAL Collins, V Pirro, BA Droz, AK Holland, ... The Journal of clinical investigation 131 (12), 2021 | 89 | 2021 |
| Inactivation of phosphorylase is a major component of the mechanism by which insulin stimulates hepatic glycogen synthesis S Aiston, MP Coghlan, L Agius European journal of biochemistry 270 (13), 2773-2781, 2003 | 89 | 2003 |
| Use of lithium and SB‐415286 to explore the role of glycogen synthase kinase‐3 in the regulation of glucose transport and glycogen synthase K MacAulay, E Hajduch, AS Blair, MP Coghlan, SA Smith, HS Hundal European Journal of Biochemistry 270 (18), 3829-3838, 2003 | 83 | 2003 |
| Small molecule glucokinase activators as novel anti-diabetic agents B Leighton, A Atkinson, MP Coghlan Biochemical Society Transactions 33 (2), 371-374, 2005 | 75 | 2005 |
| Site-specific anti-phosphopeptide antibodies: use in assessing insulin receptor serine/threonine phosphorylation state and identification of serine-1327 as a novel site of … MP Coghlan, TS Pillay, JM Tavare, K Siddle Biochemical Journal 303 (3), 893-899, 1994 | 58 | 1994 |
| A monoclonal anti-peptide antibody reacting with the insulin receptor β-subunit. Characterization of the antibody and its epitope and use in immunoaffinity … RH Ganderton, KK Stanley, CE Field, MP Coghlan, MA Soos, K Siddle Biochemical Journal 288 (1), 195-205, 1992 | 57 | 1992 |
| 40th EASD Annual Meeting of the European Association for the Study of Diabetes: Munich, Germany, 5–9 September 2004 M Veitenhansl, K Stegner, FX Hierl, C Dieterle, H Feldmeier, B Gutt, ... Diabetologia 47, A1-A464, 2004 | 51 | 2004 |
