| mRNA capping: biological functions and applications A Ramanathan, GB Robb, SH Chan Nucleic acids research 44 (16), 7511-7526, 2016 | 746 | 2016 |
| Structural basis of RNA cap modification by SARS-CoV-2 T Viswanathan, S Arya, SH Chan, S Qi, N Dai, A Misra, JG Park, ... Nature communications 11 (1), 3718, 2020 | 208 | 2020 |
| Natural and engineered nicking endonucleases—from cleavage mechanism to engineering of strand-specificity SH Chan, BL Stoddard, S Xu Nucleic acids research 39 (1), 1-18, 2011 | 126 | 2011 |
| A type IV modification-dependent restriction enzyme SauUSI from Staphylococcus aureus subsp. aureus USA300 S Xu, AR Corvaglia, SH Chan, Y Zheng, P Linder Nucleic acids research 39 (13), 5597-5610, 2011 | 114 | 2011 |
| Trichosanthin interacts with acidic ribosomal proteins P0 and P1 and mitotic checkpoint protein MAD2B SH Chan, FSJ Hung, DSB Chan, PC Shaw European Journal of Biochemistry 268 (7), 2107-2112, 2001 | 65 | 2001 |
| Discovery of natural nicking endonucleases Nb. BsrDI and Nb. BtsI and engineering of top-strand nicking variants from BsrDI and BtsI SY Xu, Z Zhu, P Zhang, SH Chan, JC Samuelson, J Xiao, D Ingalls, ... Nucleic acids research 35 (14), 4608-4618, 2007 | 58 | 2007 |
| Structural basis of asymmetric DNA methylation and ATP-triggered long-range diffusion by EcoP15I YK Gupta, SH Chan, S Xu, AK Aggarwal Nature Communications 6 (1), 7363, 2015 | 55 | 2015 |
| Cloning of CviPII nicking and modification system from chlorella virus NYs-1 and application of Nt. CviPII in random DNA amplification S Chan, Z Zhu, JL Van Etten, S Xu Nucleic acids research 32 (21), 6187-6199, 2004 | 55 | 2004 |
| Unusual target site disruption by the rare-cutting HNH restriction endonuclease PacI BW Shen, DF Heiter, SH Chan, H Wang, SY Xu, RD Morgan, GG Wilson, ... Structure 18 (6), 734-743, 2010 | 49 | 2010 |
| Engineering of a mini-trichosanthin that has lower antigenicity by deleting its C-terminal amino acid residues SH Chan, PC Shaw, SFC Mulot, LH Xu, WL Chan, SC Tam, KB Wong Biochemical and Biophysical Research Communications 270 (1), 279-285, 2000 | 41 | 2000 |
| Characterization and crystal structure of the type IIG restriction endonuclease RM. BpuSI BW Shen, D Xu, SH Chan, Y Zheng, Z Zhu, S Xu, BL Stoddard Nucleic acids research 39 (18), 8223-8236, 2011 | 40 | 2011 |
| Catalytic domain of restriction endonuclease BmrI as a cleavage module for engineering endonucleases with novel substrate specificities S Chan, Y Bao, E Ciszak, S Laget, S Xu Nucleic acids research 35 (18), 6238-6248, 2007 | 36 | 2007 |
| Engineering BspQI nicking enzymes and application of N. BspQI in DNA labeling and production of single-strand DNA P Zhang, PHM Too, JC Samuelson, SH Chan, T Vincze, S Doucette, ... Protein expression and purification 69 (2), 226-234, 2010 | 33 | 2010 |
| Crystal structure of the restriction-modification system control element C. BclI and mapping of its binding site MR Sawaya, Z Zhu, F Mersha, S Chan, R Dabur, S Xu, GK Balendiran Structure 13 (12), 1837-1847, 2005 | 32 | 2005 |
| A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide T Viswanathan, A Misra, SH Chan, S Qi, N Dai, S Arya, ... Nature communications 12 (1), 3287, 2021 | 26 | 2021 |
| Cofactor requirement of HpyAV restriction endonuclease SH Chan, L Opitz, L Higgins, D O'loane, S Xu PLoS One 5 (2), e9071, 2010 | 26 | 2010 |
| Cloning of Nt. CviQII nicking endonuclease and its cognate methyltransferase: M. CviQII methylates AG sequences S Chan, Z Zhu, DD Dunigan, JL Van Etten, S Xu Protein expression and purification 49 (1), 138-150, 2006 | 24 | 2006 |
| Expression and purification of BmrI restriction endonuclease and its N-terminal cleavage domain variants Y Bao, L Higgins, P Zhang, S Chan, S Laget, S Sweeney, K Lunnen, S Xu Protein expression and purification 58 (1), 42-52, 2008 | 21 | 2008 |
| Solution structure and thermal stability of ribosomal protein L30e from hyperthermophilic archaeon Thermococcus celer KB Wong, CF Lee, SH Chan, TY Leung, YW Chen, M Bycroft Protein science 12 (7), 1483-1495, 2003 | 20 | 2003 |
| Engineering Nt. BtsCI and Nb. BtsCI nicking enzymes and applications in generating long overhangs PHM Too, Z Zhu, SH Chan, S Xu Nucleic acids research 38 (4), 1294-1303, 2010 | 19 | 2010 |
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