| Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer J Liang, M Nagahashi, EY Kim, KB Harikumar, A Yamada, WC Huang, ... Cancer cell 23 (1), 107-120, 2013 | 581 | 2013 |
| Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis M Nagahashi, S Ramachandran, EY Kim, JC Allegood, OM Rashid, ... Cancer research 72 (3), 726-735, 2012 | 350 | 2012 |
| Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2 K Takabe, RH Kim, JC Allegood, P Mitra, S Ramachandran, M Nagahashi, ... Journal of Biological Chemistry 285 (14), 10477-10486, 2010 | 307 | 2010 |
| Conjugated bile acids activate the sphingosine‐1‐phosphate receptor 2 in primary rodent hepatocytes E Studer, X Zhou, R Zhao, Y Wang, K Takabe, M Nagahashi, WM Pandak, ... Hepatology 55 (1), 267-276, 2012 | 303 | 2012 |
| p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming T Saito, Y Ichimura, K Taguchi, T Suzuki, T Mizushima, K Takagi, Y Hirose, ... Nature communications 7 (1), 12030, 2016 | 298 | 2016 |
| Conjugated bile acid–activated S1P receptor 2 is a key regulator of sphingosine kinase 2 and hepatic gene expression M Nagahashi, K Takabe, R Liu, K Peng, X Wang, Y Wang, NC Hait, ... Hepatology 61 (4), 1216-1226, 2015 | 182 | 2015 |
| Targeting the SphK1/S1P/S1PR1 axis that links obesity, chronic inflammation, and breast cancer metastasis M Nagahashi, A Yamada, E Katsuta, T Aoyagi, WC Huang, KP Terracina, ... Cancer research 78 (7), 1713-1725, 2018 | 180 | 2018 |
| The role of sphingosine 1‐phosphate receptor 2 in bile‐acid–induced cholangiocyte proliferation and cholestasis‐induced liver injury in mice Y Wang, H Aoki, J Yang, K Peng, R Liu, X Li, X Qiang, L Sun, EC Gurley, ... Hepatology 65 (6), 2005-2018, 2017 | 175 | 2017 |
| Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network M Nagahashi, EY Kim, A Yamada, S Ramachandran, JC Allegood, ... The FASEB Journal 27 (3), 1001, 2013 | 171 | 2013 |
| Next generation sequencing‐based gene panel tests for the management of solid tumors M Nagahashi, Y Shimada, H Ichikawa, H Kameyama, K Takabe, S Okuda, ... Cancer science 110 (1), 6-15, 2019 | 137 | 2019 |
| Preoperative predictors of vascular invasion in hepatocellular carcinoma J Sakata, Y Shirai, T Wakai, K Kaneko, M Nagahashi, K Hatakeyama European Journal of Surgical Oncology (EJSO) 34 (8), 900-905, 2008 | 128 | 2008 |
| Resolvins and omega three polyunsaturated fatty acids: Clinical implications in inflammatory diseases and cancer K Moro, M Nagahashi, R Ramanathan, K Takabe, T Wakai World journal of clinical cases 4 (7), 155, 2016 | 118 | 2016 |
| Is tail vein injection a relevant breast cancer lung metastasis model? OM Rashid, M Nagahashi, S Ramachandran, CI Dumur, JC Schaum, ... Journal of thoracic disease 5 (4), 385, 2013 | 118 | 2013 |
| Sphingosine-1-phosphate transporters as targets for cancer therapy M Nagahashi, K Takabe, KP Terracina, D Soma, Y Hirose, T Kobayashi, ... BioMed research international 2014, 2014 | 111 | 2014 |
| Resection of the primary tumor improves survival in metastatic breast cancer by reducing overall tumor burden OM Rashid, M Nagahashi, S Ramachandran, L Graham, A Yamada, ... Surgery 153 (6), 771-778, 2013 | 110 | 2013 |
| The phosphorylated prodrug FTY720 is a histone deacetylase inhibitor that reactivates ERα expression and enhances hormonal therapy for breast cancer NC Hait, D Avni, A Yamada, M Nagahashi, T Aoyagi, H Aoki, CI Dumur, ... Oncogenesis 4 (6), e156-e156, 2015 | 106 | 2015 |
| The role of sphingosine‐1‐phosphate in inflammation and cancer progression M Nagahashi, M Abe, K Sakimura, K Takabe, T Wakai Cancer science 109 (12), 3671-3678, 2018 | 101 | 2018 |
| The roles of bile acids and sphingosine-1-phosphate signaling in the hepatobiliary diseases M Nagahashi, K Yuza, Y Hirose, M Nakajima, R Ramanathan, NC Hait, ... Journal of lipid research 57 (9), 1636-1643, 2016 | 98 | 2016 |
| The E2F pathway score as a predictive biomarker of response to neoadjuvant therapy in ER+/HER2− breast cancer M Oshi, H Takahashi, Y Tokumaru, L Yan, OM Rashid, M Nagahashi, ... Cells 9 (7), 1643, 2020 | 92 | 2020 |
| High levels of sphingolipids in human breast cancer M Nagahashi, J Tsuchida, K Moro, M Hasegawa, K Tatsuda, IA Woelfel, ... journal of surgical research 204 (2), 435-444, 2016 | 92 | 2016 |
Kazuaki Takabe MD PhD FACSRoswell Park Cancer InstituteVerified email at roswellpark.org
