Spencer Peck
Spencer Peck
Post-doctoral research associate, Harvard University
Verified email at fas.harvard.edu
Title
Cited by
Cited by
Year
A prominent glycyl radical enzyme in human gut microbiomes metabolizes trans-4-hydroxy-l-proline
BJ Levin, YY Huang, SC Peck, Y Wei, A Martinez-Del Campo, JA Marks, ...
Science 355 (6325), 2017
932017
Evidence that the fosfomycin-producing epoxidase, HppE, is a non–heme-iron peroxidase
C Wang, W Chang, Y Guo, H Huang, SC Peck, ME Pandelia, G Lin, H Liu, ...
Science 342 (6161), 991-995, 2013
542013
A glycyl radical enzyme enables hydrogen sulfide production by the human intestinal bacterium Bilophila wadsworthia
SC Peck, K Denger, A Burrichter, SM Irwin, EP Balskus, D Schleheck
Proceedings of the National Academy of Sciences 116 (8), 3171-3176, 2019
532019
Phosphonate biosynthesis and catabolism: a treasure trove of unusual enzymology
SC Peck, WA van der Donk
Current opinion in chemical biology 17 (4), 580-588, 2013
492013
Structural basis for methylphosphonate biosynthesis
DA Born, EC Ulrich, KS Ju, SC Peck, WA Van Der Donk, CL Drennan
Science 358 (6368), 1336-1339, 2017
322017
On the stereochemistry of 2-hydroxyethylphosphonate dioxygenase
JT Whitteck, P Malova, SC Peck, RM Cicchillo, F Hammerschmidt, ...
Journal of the American Chemical Society 133 (12), 4236-4239, 2011
322011
Oxygen-18 kinetic isotope effects of nonheme iron enzymes HEPD and MPnS support iron (III) superoxide as the hydrogen abstraction species
H Zhu, SC Peck, F Bonnot, WA Van Der Donk, JP Klinman
Journal of the American Chemical Society 137 (33), 10448-10451, 2015
242015
Mechanistic investigation of methylphosphonate synthase, a non-heme iron-dependent oxygenase
HA Cooke, SC Peck, BS Evans, WA Van Der Donk
Journal of the American Chemical Society 134 (38), 15660-15663, 2012
242012
Go it alone: four-electron oxidations by mononuclear non-heme iron enzymes
SC Peck, WA van der Donk
JBIC Journal of Biological Inorganic Chemistry 22 (2-3), 381-394, 2017
232017
Mechanism and substrate recognition of 2-hydroxyethylphosphonate dioxygenase
SC Peck, HA Cooke, RM Cicchillo, P Malova, F Hammerschmidt, SK Nair, ...
Biochemistry 50 (30), 6598-6605, 2011
222011
A common late-stage intermediate in catalysis by 2-hydroxyethyl-phosphonate dioxygenase and methylphosphonate synthase
SC Peck, JR Chekan, EC Ulrich, SK Nair, WA Van Der Donk
Journal of the American Chemical Society 137 (9), 3217-3220, 2015
192015
Discovery and biosynthesis of phosphonate and phosphinate natural products
SC Peck, J Gao, WA Van Der Donk
Methods in enzymology 516, 101-123, 2012
192012
O–H activation by an unexpected ferryl intermediate during catalysis by 2-hydroxyethylphosphonate dioxygenase
SC Peck, C Wang, LMK Dassama, B Zhang, Y Guo, LJ Rajakovich, ...
Journal of the American Chemical Society 139 (5), 2045-2052, 2017
182017
Structure and function of phosphonoacetaldehyde dehydrogenase: the missing link in phosphonoacetate formation
V Agarwal, SC Peck, JH Chen, SA Borisova, JR Chekan, ...
Chemistry & biology 21 (1), 125-135, 2014
162014
Stereochemistry of hydride transfer by group III alcohol dehydrogenases involved in phosphonate biosynthesis
SC Peck, SY Kim, BS Evans, WA Van Der Donk
MedChemComm 3 (8), 967-970, 2012
82012
Use of the dehydrophos biosynthetic enzymes to prepare antimicrobial analogs of alaphosphin
DJ Bougioukou, CP Ting, SC Peck, S Mukherjee, WA Van Der Donk
Organic & biomolecular chemistry 17 (4), 822-829, 2019
62019
Elucidating the Mechanism of CS Bond Cleavage in Isethionate Sulfite-Lyase
C Dawson, S Peck, S Irwin, E Balskus, C Drennan
PROTEIN SCIENCE 27, 195-196, 2018
2018
Involvement of metal-superoxo species in iron and copper CH activating enzymes
J Klinman, H Zhu, S Peck, F Bonnot, W van der Donk
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 251, 2016
2016
Mechanistic investigations of enzymes in phosphonate metabolism
SC Peck
University of Illinois at Urbana-Champaign, 2014
2014
Positive and radical
SC Peck, WA Van Der Donk
Nature 496 (7443), 34-35, 2013
2013
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Articles 1–20