The renin–angiotensin system and cancer: old dog, new tricks AJ George, WG Thomas, RD Hannan Nature Reviews Cancer 10 (11), 745-759, 2010 | 556 | 2010 |
ATRX interacts with H3. 3 in maintaining telomere structural integrity in pluripotent embryonic stem cells LH Wong, JD McGhie, M Sim, MA Anderson, S Ahn, RD Hannan, ... Genome research 20 (3), 351-360, 2010 | 448 | 2010 |
AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy MV Astle, KM Hannan, PY Ng, RS Lee, AJ George, AK Hsu, Y Haupt, ... Oncogene 31 (15), 1949-1962, 2012 | 276 | 2012 |
The nucleolus: an emerging target for cancer therapy N Hein, KM Hannan, AJ George, E Sanij, RD Hannan Trends in molecular medicine 19 (11), 643-654, 2013 | 270 | 2013 |
The β-amyloid protein of Alzheimer's disease increases neuronal CRMP-2 phosphorylation by a Rho-GTP mechanism S Petratos, QX Li, AJ George, X Hou, ML Kerr, SE Unabia, I Hatzinisiriou, ... Brain 131 (1), 90-108, 2007 | 223 | 2007 |
APP intracellular domain is increased and soluble Aβ is reduced with diet-induced hypercholesterolemia in a transgenic mouse model of Alzheimer disease AJ George, RM Holsinger, CA McLean, KM Laughton, K Beyreuther, ... Neurobiology of disease 16 (1), 124-132, 2004 | 125 | 2004 |
Combination therapy targeting ribosome biogenesis and mRNA translation synergistically extends survival in MYC-driven lymphoma JR Devlin, KM Hannan, N Hein, C Cullinane, E Kusnadi, PY Ng, ... Cancer discovery 6 (1), 59-70, 2016 | 124 | 2016 |
Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling J Quin, KT Chan, JR Devlin, DP Cameron, J Diesch, C Cullinane, J Ahern, ... Oncotarget 7 (31), 49800-49818, 2016 | 105 | 2016 |
Decreased phosphatidylethanolamine binding protein expression correlates with Aβ accumulation in the Tg2576 mouse model of Alzheimer's disease AJ George, RM Holsinger, CA McLean, SS Tan, HS Scott, T Cardamone, ... Neurobiology of aging 27 (4), 614-623, 2006 | 93 | 2006 |
Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population N Hein, DP Cameron, KM Hannan, NYN Nguyen, CY Fong, J Sornkom, ... Blood 129 (21), 2882-2895, 2017 | 85 | 2017 |
The angiotensin receptor blocker, Losartan, inhibits mammary tumor development and progression to invasive carcinoma R Coulson, SH Liew, AA Connelly, NS Yee, S Deb, B Kumar, AC Vargas, ... Oncotarget 8 (12), 18640, 2017 | 76 | 2017 |
Unravelling the molecular complexity of GPCR‐mediated EGFR transactivation using functional genomics approaches AJ George, RD Hannan, WG Thomas The FEBS journal 280 (21), 5258-5268, 2013 | 74 | 2013 |
New roles for the nucleolus in health and disease L Núñez Villacís, MS Wong, LL Ferguson, N Hein, AJ George, ... Bioessays 40 (5), 1700233, 2018 | 69 | 2018 |
A serial analysis of gene expression profile of the Alzheimer’s disease Tg2576 mouse model AJ George, L Gordon, T Beissbarth, I Koukoulas, RMD Holsinger, ... Neurotoxicity research 17, 360-379, 2010 | 66 | 2010 |
A functional genetic screen defines the AKT-induced senescence signaling network KT Chan, S Blake, H Zhu, J Kang, AS Trigos, PB Madhamshettiwar, ... Cell Death & Differentiation 27 (2), 725-741, 2020 | 49 | 2020 |
A functional siRNA screen identifies genes modulating angiotensin II-mediated EGFR transactivation AJ George, BW Purdue, CM Gould, DW Thomas, Y Handoko, H Qian, ... J Cell Sci 126 (23), 5377-5390, 2013 | 34 | 2013 |
Self-reverting mutations partially correct the blood phenotype in a Diamond Blackfan Anemia patient. P Venugopal, S Moore, DM Lawrence, AJ George, RD Hannan, SC Bray, ... Haematologica, 2017 | 30 | 2017 |
Nuclear stabilization of p53 requires a functional nucleolar surveillance pathway KM Hannan, P Soo, MS Wong, JK Lee, N Hein, P Poh, KD Wysoke, ... Cell Reports 41 (5), 111571, 2022 | 26 | 2022 |
Cohesin mutations are synthetic lethal with stimulation of WNT signaling CV Chin, J Antony, S Ketharnathan, A Labudina, G Gimenez, KM Parsons, ... Elife 9, e61405, 2020 | 25 | 2020 |
Glucocorticoids improve erythroid progenitor maintenance and dampen Trp53 response in a mouse model of Diamond–Blackfan anaemia SE Sjögren, K Siva, S Soneji, AJ George, M Winkler, P Jaako, ... British journal of haematology 171 (4), 517-529, 2015 | 24 | 2015 |