| Large conformational changes in proteins: signaling and other functions BJ Grant, AA Gorfe, JA McCammon Current opinion in structural biology 20 (2), 142-147, 2010 | 276 | 2010 |
| Structural determinants and functional consequences of protein affinity for membrane rafts JH Lorent, B Diaz-Rohrer, X Lin, K Spring, AA Gorfe, KR Levental, ... Nature communications 8 (1), 1219, 2017 | 271 | 2017 |
| Lipid-sorting specificity encoded in K-Ras membrane anchor regulates signal output Y Zhou, P Prakash, H Liang, KJ Cho, AA Gorfe, JF Hancock Cell 168 (1), 239-251. e16, 2017 | 270 | 2017 |
| Ras membrane orientation and nanodomain localization generate isoform diversity D Abankwa, AA Gorfe, K Inder, JF Hancock Proceedings of the National Academy of Sciences 107 (3), 1130-1135, 2010 | 257 | 2010 |
| Mapping the nucleotide and isoform-dependent structural and dynamical features of Ras proteins AA Gorfe, BJ Grant, JA McCammon Structure 16 (6), 885-896, 2008 | 237 | 2008 |
| Structure and dynamics of the full-length lipid-modified H-Ras protein in a 1, 2-dimyristoylglycero-3-phosphocholine bilayer AA Gorfe, M Hanzal-Bayer, D Abankwa, JF Hancock, JA McCammon Journal of medicinal chemistry 50 (4), 674-684, 2007 | 221 | 2007 |
| A novel switch region regulates H‐ras membrane orientation and signal output D Abankwa, M Hanzal‐Bayer, N Ariotti, SJ Plowman, AA Gorfe, RG Parton, ... The EMBO journal 27 (5), 727-735, 2008 | 210 | 2008 |
| Ras conformational switching: simulating nucleotide-dependent conformational transitions with accelerated molecular dynamics BJ Grant, AA Gorfe, JA McCammon PLoS computational biology 5 (3), e1000325, 2009 | 202 | 2009 |
| Polyunsaturated lipids regulate membrane domain stability by tuning membrane order KR Levental, JH Lorent, X Lin, AD Skinkle, MA Surma, EA Stockenbojer, ... Biophysical journal 110 (8), 1800-1810, 2016 | 201 | 2016 |
| Novel allosteric sites on Ras for lead generation BJ Grant, S Lukman, HJ Hocker, J Sayyah, JH Brown, JA McCammon, ... PloS one 6 (10), e25711, 2011 | 193 | 2011 |
| Organization, dynamics, and segregation of Ras nanoclusters in membrane domains L Janosi, Z Li, JF Hancock, AA Gorfe Proceedings of the National Academy of Sciences, 2012 | 181 | 2012 |
| Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function HJ Hocker, KJ Cho, CYK Chen, N Rambahal, SR Sagineedu, K Shaari, ... Proceedings of the National Academy of Sciences 110 (25), 10201-10206, 2013 | 164 | 2013 |
| Ras nanoclusters: molecular structure and assembly D Abankwa, AA Gorfe, JF Hancock Seminars in cell & developmental biology 18 (5), 599-607, 2007 | 149 | 2007 |
| Oncogenic K-Ras binds to an anionic membrane in two distinct orientations: a molecular dynamics analysis P Prakash, Y Zhou, H Liang, JF Hancock, AA Gorfe Biophysical journal 110 (5), 1125-1138, 2016 | 140 | 2016 |
| Simulating POPC and POPC/POPG bilayers: conserved packing and altered surface reactivity L Janosi, AA Gorfe Journal of chemical theory and computation 6 (10), 3267-3273, 2010 | 128 | 2010 |
| Staurosporines disrupt phosphatidylserine trafficking and mislocalize Ras proteins K Cho, JH Park, AM Piggott, AA Salim, AA Gorfe, RG Parton, RJ Capon, ... Journal of Biological Chemistry 287 (52), 43573-43584, 2012 | 114 | 2012 |
| Functional plasticity in the substrate binding site of β-secretase AA Gorfe, A Caflisch Structure 13 (10), 1487-1498, 2005 | 109 | 2005 |
| Computational and biochemical characterization of two partially overlapping interfaces and multiple weak-affinity K-Ras dimers P Prakash, A Sayyed-Ahmad, KJ Cho, DM Dolino, W Chen, H Li, BJ Grant, ... Scientific reports 7 (1), 40109, 2017 | 103 | 2017 |
| The distinct conformational dynamics of K-Ras and H-Ras A59G S Lukman, BJ Grant, AA Gorfe, GH Grant, JA McCammon PLoS computational biology 6 (9), e1000922, 2010 | 99 | 2010 |
| Isoform selectivity of adenylyl cyclase inhibitors: characterization of known and novel compounds CS Brand, HJ Hocker, AA Gorfe, CN Cavasotto, CW Dessauer Journal of Pharmacology and Experimental Therapeutics 347 (2), 265-275, 2013 | 97 | 2013 |
John F HancockUniversity of Texas Medial School at HoustonVerified email at uth.tmc.edu
