Pratiksha I. Thakore
Pratiksha I. Thakore
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Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers
IB Hilton, AM D'ippolito, CM Vockley, PI Thakore, GE Crawford, TE Reddy, ...
Nature biotechnology 33 (5), 510-517, 2015
RNA-guided gene activation by CRISPR-Cas9–based transcription factors
P Perez-Pinera, DD Kocak, CM Vockley, AF Adler, AM Kabadi, ...
Nature methods 10 (10), 973-976, 2013
In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy
CE Nelson, CH Hakim, DG Ousterout, PI Thakore, EA Moreb, RMC Rivera, ...
Science 351 (6271), 403-407, 2016
Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements
PI Thakore, AM D'ippolito, L Song, A Safi, NK Shivakumar, AM Kabadi, ...
Nature methods 12 (12), 1143-1149, 2015
Multiplex CRISPR/Cas9-based genome editing for correction of dystrophin mutations that cause Duchenne muscular dystrophy
DG Ousterout, AM Kabadi, PI Thakore, WH Majoros, TE Reddy, ...
Nature communications 6 (1), 6244, 2015
Editing the epigenome: technologies for programmable transcription and epigenetic modulation
PI Thakore, JB Black, IB Hilton, CA Gersbach
Nature methods 13 (2), 127-137, 2016
Scalable, multimodal profiling of chromatin accessibility, gene expression and protein levels in single cells
EP Mimitou, CA Lareau, KY Chen, AL Zorzetto-Fernandes, Y Hao, ...
Nature biotechnology 39 (10), 1246-1258, 2021
Cycling cancer persister cells arise from lineages with distinct programs
Y Oren, M Tsabar, MS Cuoco, L Amir-Zilberstein, HF Cabanos, JC Hütter, ...
Nature 596 (7873), 576-582, 2021
Metabolic modeling of single Th17 cells reveals regulators of autoimmunity
A Wagner, C Wang, J Fessler, D DeTomaso, J Avila-Pacheco, J Kaminski, ...
Cell 184 (16), 4168-4185. e21, 2021
Reading frame correction by targeted genome editing restores dystrophin expression in cells from Duchenne muscular dystrophy patients
DG Ousterout, P Perez-Pinera, PI Thakore, AM Kabadi, MT Brown, X Qin, ...
Molecular Therapy 21 (9), 1718-1726, 2013
Calcitonin gene-related peptide negatively regulates alarmin-driven type 2 innate lymphoid cell responses
A Wallrapp, PR Burkett, SJ Riesenfeld, SJ Kim, E Christian, ...
Immunity 51 (4), 709-723. e6, 2019
RNA-guided transcriptional silencing in vivo with S. aureus CRISPR-Cas9 repressors
PI Thakore, JB Kwon, CE Nelson, DC Rouse, MP Gemberling, ML Oliver, ...
Nature communications 9 (1), 1674, 2018
Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion
CJ Frangieh, JC Melms, PI Thakore, KR Geiger-Schuller, P Ho, ...
Nature genetics 53 (3), 332-341, 2021
Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes
E Kiner, E Willie, B Vijaykumar, K Chowdhary, H Schmutz, J Chandler, ...
Nature immunology 22 (2), 216-228, 2021
Correction of dystrophin expression in cells from Duchenne muscular dystrophy patients through genomic excision of exon 51 by zinc finger nucleases
DG Ousterout, AM Kabadi, PI Thakore, P Perez-Pinera, MT Brown, ...
Molecular Therapy 23 (3), 523-532, 2015
Stem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity
A Schnell, L Huang, M Singer, A Singaraju, RM Barilla, BML Regan, ...
Cell 184 (26), 6281-6298. e23, 2021
RNA-guided gene editing and gene regulation
CA Gersbach, IB Hilton, P Perez-Pinera, AM Kabadi, PI Thakore, ...
US Patent 10,704,060, 2020
CRISPR-based epigenome editing of cytokine receptors for the promotion of cell survival and tissue deposition in inflammatory environments
N Farhang, JM Brunger, JD Stover, PI Thakore, B Lawrence, F Guilak, ...
Tissue Engineering Part A 23 (15-16), 738-749, 2017
Environmental regulation of notochordal gene expression in nucleus pulposus cells
A Rastogi, P Thakore, A Leung, M Benavides, M Machado, ...
Journal of cellular physiology 220 (3), 698-705, 2009
An IL-27-driven transcriptional network identifies regulators of IL-10 expression across T helper cell subsets
H Zhang, A Madi, N Yosef, N Chihara, A Awasthi, C Pot, C Lambden, ...
Cell reports 33 (8), 2020
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