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Mercedes Prudencio
Mercedes Prudencio
Associate Professor in Neuroscience, Mayo Clinic Jacksonville
Verified email at mayo.edu - Homepage
Title
Cited by
Cited by
Year
C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits
J Chew, TF Gendron, M Prudencio, H Sasaguri, YJ Zhang, ...
Science 348 (6239), 1151-1154, 2015
4472015
Aggregation-prone c9FTD/ALS poly (GA) RAN-translated proteins cause neurotoxicity by inducing ER stress
YJ Zhang, K Jansen-West, YF Xu, TF Gendron, KF Bieniek, WL Lin, ...
Acta neuropathologica 128, 505-524, 2014
3762014
Distinct brain transcriptome profiles in C9orf72-associated and sporadic ALS
M Prudencio, VV Belzil, R Batra, CA Ross, TF Gendron, LJ Pregent, ...
Nature neuroscience 18 (8), 1175-1182, 2015
3652015
Reduced C9orf72 gene expression in c9FTD/ALS is caused by histone trimethylation, an epigenetic event detectable in blood
VV Belzil, PO Bauer, M Prudencio, TF Gendron, CT Stetler, IK Yan, ...
Acta neuropathologica 126, 895-905, 2013
3292013
Variation in aggregation propensities among ALS-associated variants of SOD1: correlation to human disease
M Prudencio, PJ Hart, DR Borchelt, PM Andersen
Human molecular genetics 18 (17), 3217-3226, 2009
2902009
Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis
YJ Zhang, TF Gendron, MTW Ebbert, AD O’Raw, M Yue, K Jansen-West, ...
Nature medicine 24 (8), 1136-1142, 2018
2692018
Role of mutant SOD1 disulfide oxidation and aggregation in the pathogenesis of familial ALS
CM Karch, M Prudencio, DD Winkler, PJ Hart, DR Borchelt
Proceedings of the National Academy of Sciences 106 (19), 7774-7779, 2009
2262009
Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis
TF Gendron, J Chew, JN Stankowski, LR Hayes, YJ Zhang, M Prudencio, ...
Science translational medicine 9 (383), eaai7866, 2017
2152017
TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A
XR Ma, M Prudencio, Y Koike, SC Vatsavayai, G Kim, F Harbinski, ...
Nature 603 (7899), 124-130, 2022
2132022
Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity
YJ Zhang, L Guo, PK Gonzales, TF Gendron, Y Wu, K Jansen-West, ...
Science 363 (6428), eaav2606, 2019
1992019
A method to determine RNA and DNA oxidation simultaneously by HPLC-ECD: greater RNA than DNA oxidation in rat liver after doxorubicin administration
T Hofer, AY Seo, M Prudencio, C Leeuwenburgh
Walter de Gruyter 387 (1), 103-111, 2006
1552006
Spt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts
NJ Kramer, Y Carlomagno, YJ Zhang, S Almeida, CN Cook, TF Gendron, ...
Science 353 (6300), 708-712, 2016
1332016
Immature copper-zinc superoxide dismutase and familial amyotrophic lateral sclerosis
SV Seetharaman, M Prudencio, C Karch, SP Holloway, DR Borchelt, ...
Experimental biology and medicine 234 (10), 1140-1154, 2009
1202009
Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia
M Prudencio, J Humphrey, S Pickles, AL Brown, SE Hill, JM Kachergus, ...
The Journal of clinical investigation 130 (11), 2020
1192020
Long-read sequencing across the C9orf72 ‘GGGGCC’ repeat expansion: implications for clinical use and genetic discovery efforts in human disease
MTW Ebbert, SL Farrugia, JP Sens, K Jansen-West, TF Gendron, ...
Molecular neurodegeneration 13, 1-17, 2018
1092018
Repetitive element transcripts are elevated in the brain of C9orf72 ALS/FTLD patients
M Prudencio, PK Gonzales, CN Cook, TF Gendron, LM Daughrity, Y Song, ...
Human molecular genetics 26 (17), 3421-3431, 2017
1062017
Targeted manipulation of the sortilin–progranulin axis rescues progranulin haploinsufficiency
WC Lee, S Almeida, M Prudencio, TR Caulfield, YJ Zhang, WM Tay, ...
Human Molecular Genetics 23 (6), 1467-1478, 2014
1052014
Phosphorylated neurofilament heavy chain: A biomarker of survival for C9ORF72‐associated amyotrophic lateral sclerosis
TF Gendron, LM Daughrity, MG Heckman, NN Diehl, J Wuu, TM Miller, ...
Annals of neurology 82 (1), 139-146, 2017
972017
Misregulation of human sortilin splicing leads to the generation of a nonfunctional progranulin receptor
M Prudencio, KR Jansen-West, WC Lee, TF Gendron, YJ Zhang, YF Xu, ...
Proceedings of the National Academy of Sciences 109 (52), 21510-21515, 2012
942012
TDP-43 functions within a network of hnRNP proteins to inhibit the production of a truncated human SORT1 receptor
F Mohagheghi, M Prudencio, C Stuani, C Cook, K Jansen-West, ...
Human molecular genetics 25 (3), 534-545, 2016
892016
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